{"id":4102,"date":"2021-11-12T15:16:57","date_gmt":"2021-11-12T20:16:57","guid":{"rendered":"https:\/\/www.med.unc.edu\/corefacilities\/?page_id=4102"},"modified":"2025-12-04T10:37:07","modified_gmt":"2025-12-04T15:37:07","slug":"rrt","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/corefacilities\/rrt\/","title":{"rendered":"Rigor and Reproducibility"},"content":{"rendered":"<som-cell cell-info=\"{&quot;ID&quot;:6065,&quot;post_author&quot;:&quot;55643&quot;,&quot;post_date&quot;:&quot;2025-07-25 14:59:40&quot;,&quot;post_date_gmt&quot;:&quot;2025-07-25 18:59:40&quot;,&quot;post_content&quot;:&quot;&quot;,&quot;post_title&quot;:&quot;Rigor and Reproducibility header&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;rigor-and-reproducibility&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2025-07-25 15:56:01&quot;,&quot;post_modified_gmt&quot;:&quot;2025-07-25 19:56:01&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\\\/\\\/www.med.unc.edu\\\/corefacilities\\\/cell\\\/rigor-and-reproducibility\\\/&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;somcell&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;}\" cell-meta=\"{&quot;_wpv_contains_gutenberg_views&quot;:[&quot;&quot;],&quot;_upd_sortorder&quot;:[&quot;1&quot;],&quot;layout&quot;:[&quot;SingleCellBlocks&quot;],&quot;cellInformation&quot;:[&quot;{\\&quot;singleCellBlocks\\&quot;:{\\&quot;ctaOption\\&quot;:0,\\&quot;blockImage\\&quot;:\\&quot;https:\\\/\\\/www.med.unc.edu\\\/corefacilities\\\/wp-content\\\/uploads\\\/sites\\\/943\\\/2022\\\/03\\\/Core-RRT-info-core-directors-e1648743724571.jpeg\\&quot;,\\&quot;imagePercent\\&quot;:\\&quot;60\\&quot;,\\&quot;imageMinHeight\\&quot;:350,\\&quot;mediaType\\&quot;:\\&quot;image\\&quot;,\\&quot;textAlignment\\&quot;:\\&quot;left\\&quot;,\\&quot;titleAccent\\&quot;:1,\\&quot;cellText\\&quot;:\\&quot;The recent evidence showing the irreproducibility of significant numbers of biomedical-research publications demands immediate and substantive action. The NIH is firmly committed to making systematic changes that should reduce the frequency and severity of this problem \\u2014 but success will come only with the full engagement of the entire biomedical-research enterprise.\\\\n\\\\nCollins, F., Tabak, L. Policy: NIH plans to enhance reproducibility.\\u00a0Nature\\u00a0505,\\u00a0612\\u2013613 (2014).\\&quot;,\\&quot;cellHeader\\&quot;:\\&quot;NIH Emphasis on Rigor and Reproducibility\\&quot;,\\&quot;backgroundImageAlignmentX\\&quot;:\\&quot;right\\&quot;,\\&quot;backgroundImageAlignmentY\\&quot;:\\&quot;center\\&quot;,\\&quot;backgroundColor\\&quot;:\\&quot;lightBlue\\&quot;},\\&quot;repeatableBoxes\\&quot;:[],\\&quot;blockType\\&quot;:\\&quot;imageBlocks\\&quot;,\\&quot;blockStyle\\&quot;:\\&quot;halfImage\\&quot;}&quot;],&quot;apiCallInformation&quot;:[&quot;{}&quot;]}\"><\/som-cell>\n<p>&nbsp;<\/p>\n<som-cell cell-info=\"{&quot;ID&quot;:6069,&quot;post_author&quot;:&quot;55643&quot;,&quot;post_date&quot;:&quot;2025-07-25 16:10:48&quot;,&quot;post_date_gmt&quot;:&quot;2025-07-25 20:10:48&quot;,&quot;post_content&quot;:&quot;&quot;,&quot;post_title&quot;:&quot;Rigor and Reproducibility bottom panel&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;rigor-and-reproducibility-bottom-panel&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2025-07-25 16:10:48&quot;,&quot;post_modified_gmt&quot;:&quot;2025-07-25 20:10:48&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\\\/\\\/www.med.unc.edu\\\/corefacilities\\\/cell\\\/rigor-and-reproducibility-bottom-panel\\\/&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;somcell&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;}\" cell-meta=\"{&quot;_wpv_contains_gutenberg_views&quot;:[&quot;&quot;],&quot;_upd_sortorder&quot;:[&quot;1&quot;],&quot;layout&quot;:[&quot;RepeatableBoxes&quot;],&quot;cellInformation&quot;:[&quot;{\\&quot;singleCellBlocks\\&quot;:{},\\&quot;repeatableBoxes\\&quot;:[{\\&quot;includeLink\\&quot;:1,\\&quot;useRichTextEditor\\&quot;:\\&quot;false\\&quot;,\\&quot;boxText\\&quot;:\\&quot;UNC Core Facility Rigor and Reproducibility Template\\&quot;,\\&quot;boxExcerptText\\&quot;:\\&quot;To facilitate the Rigor and Reproducibility initiative at UNC, the Office of Research Technologies has prepared a template for use on each core\\u2019s website.  \\&quot;,\\&quot;boxUrl\\&quot;:\\&quot;https:\\\/\\\/www.med.unc.edu\\\/corefacilities\\\/wp-content\\\/uploads\\\/sites\\\/943\\\/2022\\\/04\\\/TEMPLATE-for-Rigor-and-Reproducibility_2022-CCoRRe.docx\\&quot;},{\\&quot;includeLink\\&quot;:1,\\&quot;boxExcerptText\\&quot;:\\&quot;For a well-done example of a RRT statement, see the UNC Flow Cytometry Facility (LCCC; Ramiro Diz, Director)\\&quot;,\\&quot;boxText\\&quot;:\\&quot;Sample Rigor and Reproducibility Statement\\&quot;,\\&quot;boxUrl\\&quot;:\\&quot;https:\\\/\\\/www.med.unc.edu\\\/flowcytometry\\\/resources\\\/guide-to-rigor-and-reproducibility-for-flow-cytometry-experiments\\\/\\&quot;},{\\&quot;includeLink\\&quot;:1,\\&quot;boxText\\&quot;:\\&quot;Working with Core Customers to Increase Rigor and Reproducibility at UNC Chapel Hill\\&quot;,\\&quot;boxExcerptText\\&quot;:\\&quot;Core facilities face unique challenges in supporting RRT initiatives. Click here for some suggested best practices\\&quot;,\\&quot;boxUrl\\&quot;:\\&quot;https:\\\/\\\/www.med.unc.edu\\\/corefacilities\\\/rigor-and-reproducibility-2\\\/rigor-and-reproducibility-faq\\\/\\&quot;}],\\&quot;boxCustomStyles\\&quot;:{\\&quot;textAlign\\&quot;:\\&quot;center\\&quot;,\\&quot;includeImage\\&quot;:0,\\&quot;includeImagePadding\\&quot;:1,\\&quot;imageAspectRatio\\&quot;:\\&quot;3\\\/2\\&quot;,\\&quot;includeLink\\&quot;:1,\\&quot;backgroundColor\\&quot;:\\&quot;lightBlue\\&quot;,\\&quot;columnLayout\\&quot;:\\&quot;3\\&quot;},\\&quot;boxType\\&quot;:\\&quot;imageBoxes\\&quot;,\\&quot;boxStyleOption\\&quot;:\\&quot;content-boxes\\&quot;}&quot;],&quot;apiCallInformation&quot;:[&quot;{}&quot;]}\"><\/som-cell>\n<p>In 2015, the NIH developed guidelines around the need for clear standards and emphasis to enhance rigor and transparency in the studies it supported to drive reproducible results.\u00a0 This emphasis is twofold:<\/p>\n<p>1) To establish and evaluate the rigor and reproducibility of past research which forms the bedrock for future research justifications and<\/p>\n<p>2) to address how proposed research will achieve unbiased and robust results.<\/p>\n<p>Each core at UNC is encouraged to develop Rigor and Reproducibility guidelines for their labs and to publicize these guidelines on their lab websites and make them available to core customers upon request.<\/p>\n<som-cell cell-info=\"{&quot;ID&quot;:6068,&quot;post_author&quot;:&quot;55643&quot;,&quot;post_date&quot;:&quot;2025-07-25 15:47:47&quot;,&quot;post_date_gmt&quot;:&quot;2025-07-25 19:47:47&quot;,&quot;post_content&quot;:&quot;&quot;,&quot;post_title&quot;:&quot;Rigor and Reproducibility Definitions&quot;,&quot;post_excerpt&quot;:&quot;&quot;,&quot;post_status&quot;:&quot;publish&quot;,&quot;comment_status&quot;:&quot;closed&quot;,&quot;ping_status&quot;:&quot;closed&quot;,&quot;post_password&quot;:&quot;&quot;,&quot;post_name&quot;:&quot;rigor-and-reproducibility-definitions&quot;,&quot;to_ping&quot;:&quot;&quot;,&quot;pinged&quot;:&quot;&quot;,&quot;post_modified&quot;:&quot;2025-07-25 15:49:05&quot;,&quot;post_modified_gmt&quot;:&quot;2025-07-25 19:49:05&quot;,&quot;post_content_filtered&quot;:&quot;&quot;,&quot;post_parent&quot;:0,&quot;guid&quot;:&quot;https:\\\/\\\/www.med.unc.edu\\\/corefacilities\\\/cell\\\/rigor-and-reproducibility-definitions\\\/&quot;,&quot;menu_order&quot;:0,&quot;post_type&quot;:&quot;somcell&quot;,&quot;post_mime_type&quot;:&quot;&quot;,&quot;comment_count&quot;:&quot;0&quot;,&quot;filter&quot;:&quot;raw&quot;}\" cell-meta=\"{&quot;_wpv_contains_gutenberg_views&quot;:[&quot;&quot;],&quot;_upd_sortorder&quot;:[&quot;1&quot;],&quot;layout&quot;:[&quot;RepeatableBoxes&quot;],&quot;cellInformation&quot;:[&quot;{\\&quot;singleCellBlocks\\&quot;:{},\\&quot;repeatableBoxes\\&quot;:[{\\&quot;includeLink\\&quot;:1,\\&quot;boxText\\&quot;:\\&quot;Scientific rigor\\&quot;,\\&quot;boxExcerptText\\&quot;:\\&quot;Scientific rigor is the strict application of the scientific method to ensure unbiased and well-controlled experimental design, methodology, analysis, interpretation and reporting of results. (Source: NIH Rigor and Reproducibility Webpage)\\&quot;},{\\&quot;includeLink\\&quot;:0,\\&quot;boxText\\&quot;:\\&quot;Reproducibility and Replicability\\&quot;,\\&quot;boxExcerptText\\&quot;:\\&quot;Broadly, reproducibility refers to direct replication, an attempt to replicate the original observation using the same methods of a previous investigation but collecting unique observations.Most broadly, reproducibility refers to conceptual replication, an attempt to validate the interpretation of the original observation by manipulating or measuring the same conceptual variables using different techniques. (Open Science Collaboration (p. 300-301))\\&quot;},{\\&quot;includeLink\\&quot;:0,\\&quot;boxExcerptText\\&quot;:\\&quot;Transparency refers to the clarity and thoroughness of the methods and procedures used in an experiment that lends that experiment to reproducibility and replicability.  It is often helpful to think of transparency in terms of writing a recipe.  A transparent recipe would include all information required such that 10 different chefs could create 10 identical dishes.\\&quot;,\\&quot;boxText\\&quot;:\\&quot;Transparency\\&quot;}],\\&quot;boxCustomStyles\\&quot;:{\\&quot;textAlign\\&quot;:\\&quot;center\\&quot;,\\&quot;includeImage\\&quot;:0,\\&quot;includeImagePadding\\&quot;:1,\\&quot;imageAspectRatio\\&quot;:\\&quot;3\\\/2\\&quot;,\\&quot;includeLink\\&quot;:1,\\&quot;backgroundColor\\&quot;:\\&quot;darkBlue\\&quot;,\\&quot;columnLayout\\&quot;:\\&quot;3\\&quot;},\\&quot;boxType\\&quot;:\\&quot;imageBoxes\\&quot;,\\&quot;boxStyleOption\\&quot;:\\&quot;content-boxes\\&quot;}&quot;],&quot;apiCallInformation&quot;:[&quot;{}&quot;]}\"><\/som-cell>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\">Resources for Fulfilling NIH Rigor and Reproducibility Requirements in Grant Writing<\/p>\n<p><a href=\"https:\/\/www.nih.gov\/research-training\/rigor-reproducibility\">Guidelines for Rigor and Reproducibility<\/a> from the NIH<\/p>\n<p><a href=\"https:\/\/www.nih.gov\/research-training\/rigor-reproducibility\/updated-application-instructions-enhance-rigor-reproducibility\">Grant Application Instructions<\/a> from the NIH<\/p>\n<p><a href=\"http:\/\/www.cell.com\/pb\/assets\/raw\/journals\/society\/biophysj\/PDFs\/reproducibility-guidelines.pdf\">Guidelines for Reproducibility of Biophysics Research<\/a> from the Biophysical Society<\/p>\n<p><a href=\"https:\/\/www.beilstein-institut.de\/en\/projects\/strenda\/guidelines\/\">Standards for Reporting Enzymology Data (STRENDA) Guidelines<\/a> from the Beilstein Institut<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/flowcytometry\/resources\/guide-to-rigor-and-reproducibility-for-flow-cytometry-experiments\/\">Guide to Rigor and Reproducibility for Flow Cytometry<\/a> from the UNC Flow Cytometry Core<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4609\" src=\"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-scaled.jpg\" alt=\"\" width=\"844\" height=\"546\" srcset=\"https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-scaled.jpg 2560w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-300x194.jpg 300w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-1024x663.jpg 1024w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-768x497.jpg 768w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-1536x994.jpg 1536w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-2048x1325.jpg 2048w, https:\/\/www.med.unc.edu\/corefacilities\/wp-content\/uploads\/sites\/943\/2022\/03\/NIH-grant-guidelines-for-rigor-and-reproducbility-600x388.jpg 600w\" sizes=\"auto, (max-width: 844px) 100vw, 844px\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; In 2015, the NIH developed guidelines around the need for clear standards and emphasis to enhance rigor and transparency in the studies it supported to drive reproducible results.\u00a0 This emphasis is twofold: 1) To establish and evaluate the rigor and reproducibility of past research which forms the bedrock for future research justifications and 2) &hellip; <a href=\"https:\/\/www.med.unc.edu\/corefacilities\/rrt\/\" aria-label=\"Read more about Rigor and Reproducibility\">Read more<\/a><\/p>\n","protected":false},"author":55643,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4102","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/pages\/4102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/users\/55643"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/comments?post=4102"}],"version-history":[{"count":3,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/pages\/4102\/revisions"}],"predecessor-version":[{"id":6070,"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/pages\/4102\/revisions\/6070"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/corefacilities\/wp-json\/wp\/v2\/media?parent=4102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}