{"id":2280,"date":"2013-10-28T14:30:00","date_gmt":"2013-10-28T18:30:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cpg\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism\/"},"modified":"2018-05-18T14:30:19","modified_gmt":"2018-05-18T18:30:19","slug":"autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/cpg\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism\/","title":{"rendered":"Autism article rebuttal: the perils of genetic risk prediction in autism"},"content":{"rendered":"<p><!-- description --><\/p>\n<p class=\"lead\">Dr. Sullivan and colleagues comment on findings published in Molecular Psychiatry<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><figcaption><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2412\" src=\"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/pat-sullivan-2-1.jpeg\" alt=\"\" width=\"250\" height=\"141\" srcset=\"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/pat-sullivan-2-1.jpeg 250w, https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/pat-sullivan-2-1-150x85.jpeg 150w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><\/figcaption><figcaption class=\"caption wp-caption-text\">Dr. Patrick Sullivan<\/figcaption><\/figure>\n<\/div>\n<div>\n<p><span style=\"line-height: 1.43em;\">&#8220;Last year, in <\/span><a style=\"line-height: 1.43em;\" href=\"http:\/\/www.nature.com\/mp\/journal\/vaop\/ncurrent\/full\/mp2012126a.html\">a paper published in <\/a><i style=\"line-height: 1.43em;\"><a href=\"http:\/\/www.nature.com\/mp\/journal\/vaop\/ncurrent\/full\/mp2012126a.html\">Molecular Psychiatry<\/a>,<\/i><span style=\"line-height: 1.43em;\"> Stan Skafidas and colleagues made a remarkable claim: a simple genetic test could be used to predict autism risk from birth. The degree of genetic predictive power suggested by the paper was unprecedented for a common disease, let alone for a disease <\/span><a style=\"line-height: 1.43em;\" href=\"http:\/\/www.nimh.nih.gov\/health\/topics\/autism-spectrum-disorders-pervasive-developmental-disorders\/index.shtml\">as complex and poorly understood as autism<\/a><span style=\"line-height: 1.43em;\">. However, instead of representing a revolution in autism research, many scientists felt that the paper illustrated the pitfalls of pursuing genetic risk prediction. After nearly a year of study, two papers have shown how the Skafidas et al. study demonstrates the dangers of poor experimental design and biases due to important confounders.&#8221; <\/span><em style=\"line-height: 1.43em;\">(from the article in <a class=\"external-link\" title=\"\" href=\"http:\/\/www.genomesunzipped.org\/2013\/10\/guest-post-the-perils-of-genetic-risk-prediction-in-autism.php\" target=\"_self\">Genomes Unzipped<\/a>: The perils of genetic risk prediction in autism, October 28, 2013)<\/em><\/p>\n<p><i><a class=\"external-link\" title=\"\" href=\"http:\/\/www.genomesunzipped.org\/2013\/10\/guest-post-the-perils-of-genetic-risk-prediction-in-autism.php\" target=\"_self\">Read full article in Genomes Unzipped. <\/a><\/i><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Dr. Sullivan and colleagues comment on findings published in Molecular Psychiatry<\/p>\n","protected":false},"author":22429,"featured_media":2281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2280","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism-image2.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/cpg\/wp-content\/uploads\/sites\/689\/2018\/05\/autism-article-rebuttal-the-perils-of-genetic-risk-prediction-in-autism-image2-150x85.jpeg","featured_image_alt":"Dr. Patrick Sullivan","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/cpg\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/posts\/2280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/comments?post=2280"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/posts\/2280\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/media\/2281"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/media?parent=2280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/categories?post=2280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/cpg\/wp-json\/wp\/v2\/tags?post=2280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}