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X-ray crystallography is the principal technique used to determine three-dimensional structures of molecules. The central goal of the UNC Crystallography Core Facility is to provide the support and infrastructure necessary to enable individual investigators of any experience level to initiate and successfully complete a structural biology or structural chemistry project.

The facility is state of the art, offering a variety of services in these three areas:

Sample analysis
with mass photometry




X-Ray diffraction
data collection


Structure determination
and refinement


The primary mission of the MX Facility is to work with researchers here at UNC, however, we are also able to work with researchers at non-UNC academic institutions and commercial companies.

We obtain on-going support from the UNC Lineberger Comprehensive Cancer Center through the University Cancer Research Fund and the Cancer Center Support Grant. Consequently, publications supported by the UNC Center for Structural Biology must acknowledge NIH grant P30CA016086 and be submitted to PubMed Central in compliance with the NIH Public Access Policy.

Suggested acknowledgment: “This work was performed in the UNC Protein Expression and Purification & Macromolecular Crystallography core lab supported by the National Cancer Institute of the National Institutes of Health under award number P30CA016086. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”