{"id":2226,"date":"2013-05-31T20:10:00","date_gmt":"2013-06-01T00:10:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/csb\/nmr\/instrumentation-1\/"},"modified":"2020-09-16T16:26:14","modified_gmt":"2020-09-16T20:26:14","slug":"instrumentation","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/csb\/nmr\/instrumentation\/","title":{"rendered":"Instrumentation"},"content":{"rendered":"<p>Please contact the <a href=\"https:\/\/www.med.unc.edu\/csb\/nmr\/contact\/\"><strong>director<\/strong><\/a>\u00a0to schedule use of NMR Laboratory Core Facility equipment and instrumentation.<\/p>\n<p>Clicking on the arrow to the right of each instrument below provides a description and photo, and allows you to view its scheduling calendar.<\/p>\n<div role=\"tablist\" class=\"panel-group instruments oscitas-bootstrap-container\" id=\"unc-accordion-0\">\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-0\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-0\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-0\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-0\">\n                Bruker Avance III HD 850 MHz Spectrometer            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-0\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">A Bruker Avance III HD 850 MHz four channel spectrometer equipped with a TCI H-C\/N-D 5 mm CryoProbe. The TCI CryoProbe is a proton-optimized triple resonance NMR \u2018inverse\u2019 probe, featuring three fully independent channels (plus lock channel) for simultaneous decoupling on multiple nuclei such as\u00a0<sup>13<\/sup>C and\u00a0<sup>15<\/sup>N at high sensitivity over a temperature range of -40C to 80C. The spectrometer is equipped with a 24-slot sample changer. It is primarily intended for structural studies of Proteins and Nucleic acids, Protein-Protein, Protein-RNA and Protein-Ligand interactions and Dynamics studies in solution.<\/p>\n<p><em><span style=\"font-size: 90%\">Click image for larger view.<\/span><\/em><\/p>\n<figure id=\"attachment_2367\" class=\"thumbnail wp-caption alignnone\" style=\"width: 360px\"><a href=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Brucker-Avance-III-850-MHz-Spectrometer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2367\" src=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Brucker-Avance-III-850-MHz-Spectrometer-300x280.png\" alt=\"Brucker Avance III 850 MHz Spectrometer\" width=\"350\" height=\"327\" srcset=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Brucker-Avance-III-850-MHz-Spectrometer-300x280.png 300w, https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Brucker-Avance-III-850-MHz-Spectrometer.png 454w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Bruker Avance III HD 850 MHz Spectrometer<\/figcaption><\/figure>\n<h2>Scheduling Calendar<\/h2>\n\n<!-- iframe plugin v.5.2 wordpress.org\/plugins\/iframe\/ -->\n<iframe loading=\"lazy\" src=\"https:\/\/calendar.google.com\/calendar\/embed?src=cj71h1078oflmh6rb4fvm00l68%40group.calendar.google.com&#038;ctz=America%2FNew_York\" style=\"border: 0\" width=\"800\" height=\"600\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\"><\/iframe>\n\n<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-1\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-1\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-1\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-1\">\n                Bruker Avance III HD 700 MHz Spectrometer            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-1\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">A Bruker Avance III HD 700 MHz four channel spectrometer equipped with a TCI H-C\/N-D 5 mm CryoProbe. The TCI CryoProbe is a proton-optimized triple resonance NMR \u2018inverse\u2019 probe, featuring three fully independent channels (plus lock channel) for simultaneous decoupling on multiple nuclei such as\u00a0<sup>13<\/sup>C and\u00a0<sup>15<\/sup>N at high sensitivity over a temperature range of -40C to 80C. The spectrometer is equipped with a Bruker SampleJet sample changer for high throughput applications.\u00a0 The SampleJet features 96 positions for tubes without requiring spinners (plus 3 positions for tubes with spinners) for Spinner-free open access applications and has five positions for well-plate sized NMR tube racks. This allows the handling of batches with up to 480 sample tubes. \u00a0Spectrometer allows for structural studies of Proteins and Nucleic acids, Protein-Protein, Protein-RNA and Protein-Ligand interactions, Metabolomic Studies and Fragment-Based Drug Screening in solution.<\/p>\n<p><em><span style=\"font-size: 90%\">Click image for larger view.<\/span><\/em><\/p>\n<figure id=\"attachment_2370\" class=\"thumbnail wp-caption alignnone\" style=\"width: 285px\"><a href=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-700-MHz-Spectrometer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2370\" src=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-700-MHz-Spectrometer-170x300.png\" alt=\"Bruker Avance III HD 700 MHz Spectrometer\" width=\"275\" height=\"485\" srcset=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-700-MHz-Spectrometer-170x300.png 170w, https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-700-MHz-Spectrometer.png 314w\" sizes=\"auto, (max-width: 275px) 100vw, 275px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Bruker Avance III HD 700 MHz Spectrometer<\/figcaption><\/figure>\n<h2>Scheduling Calendar<\/h2>\n\n<!-- iframe plugin v.5.2 wordpress.org\/plugins\/iframe\/ -->\n<iframe loading=\"lazy\" src=\"https:\/\/calendar.google.com\/calendar\/embed?src=439dvmbvspouja7ep1cc7jo3h0%40group.calendar.google.com&#038;ctz=America%2FNew_York\" style=\"border: 0\" width=\"800\" height=\"600\" frameborder=\"0\" 0=\"scrolling=&quot;no&quot;&gt;\" scrolling=\"yes\" class=\"iframe-class\"><\/iframe>\n\n<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-2\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-2\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-2\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-2\">\n                Bruker Avance III HD 600 MHz Spectrometer            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-2\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">A Bruker Avance III HD 600 MHz four channel spectrometer equipped with a TCI H-C\/N-D 5 mm CryoProbe. The TCI CryoProbe is a proton-optimized triple resonance NMR \u2018inverse\u2019 probe, featuring three fully independent channels (plus lock channel) for simultaneous decoupling on multiple nuclei such as\u00a0<sup>13<\/sup>C and\u00a0<sup>15<\/sup>N at high sensitivity over a temperature range of -40C to 80C.\u00a0 The spectrometer also provides site licenses for Bruker Dynamics center. \u00a0Spectrometer allows for structural studies of Proteins and Nucleic acids, Protein-Protein, Protein-RNA and Protein-Ligand interactions, Drug Discovery applications and Fragment-Based Drug Screening in solution.<\/p>\n<p><em><span style=\"font-size: 90%\">Click image for larger view.<\/span><\/em><\/p>\n<figure id=\"attachment_2369\" class=\"thumbnail wp-caption alignnone\" style=\"width: 360px\"><a href=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-600-MHz-Spectrometer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2369\" src=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-600-MHz-Spectrometer-272x300.png\" alt=\"Bruker Avance III HD 600 MHz Spectrometer\" width=\"350\" height=\"386\" srcset=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-600-MHz-Spectrometer-272x300.png 272w, https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-600-MHz-Spectrometer.png 502w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Bruker Avance III HD 600 MHz Spectrometer<\/figcaption><\/figure>\n<h2>Scheduling Calendar<\/h2>\n\n<!-- iframe plugin v.5.2 wordpress.org\/plugins\/iframe\/ -->\n<iframe loading=\"lazy\" src=\"https:\/\/calendar.google.com\/calendar\/embed?src=lo2apbt6d0rbei4hfnp84i5rb8%40group.calendar.google.com&#038;ctz=America%2FNew_York\" style=\"border: 0\" width=\"800\" height=\"600\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\"><\/iframe>\n\n<\/div>\n\n    <\/div>\n        \n<\/div>\n\n<div class=\"panel panel-default oscitas-bootstrap-container\">\n\n    <div id=\"panel-heading-details-0-3\" class=\"panel-heading oscitas-bootstrap-container\" role=\"tab\">\n\n        <h4 class=\"panel-title oscitas-bootstrap-container\">\n\n            <button class=\"accordion-toggle oscitas-bootstrap-container collapsed\" \n                id = \"button-details-0-3\"\n                data-toggle=\"collapse\"\n                data-parent=\"#unc-accordion-0\"    \n                aria-controls=\"#details-0-3\"  \n                aria-expanded=\"false\" \n                href=\"#details-0-3\">\n                Bruker Avance III HD 500 MHz Spectrometer            <\/button>\n\n        <\/h4>\n\n    <\/div>\n\n    <div id=\"details-0-3\" class=\"panel-collapse collapse  oscitas-bootstrap-container\">\n\n        <div class=\"panel-body oscitas-bootstrap-container\">A Bruker Avance III HD 500 MHz four channel spectrometer equipped with a QCI H &amp; F P\/C\/N-D 5 mm CryoProbe. The QCI CryoProbe is a proton\/fluorine-optimized quadruple resonance NMR \u2018inverse\u2019 probe, featuring four fully independent channels (plus lock channel) for simultaneous decoupling on multiple nuclei such as\u00a0<sup>13<\/sup>C,\u00a0<sup>15<\/sup>N and <sup>31<\/sup>P at high sensitivity over a temperature range of -40C to 80C.\u00a0The novel QCI quadruple resonance probe addresses bio-NMR as well as fluorine NMR screening (3-FABS, FAXS, \u2026) applications. \u00a0\u00a0Spectrometer allows for structural studies of Proteins and Nucleic acids, Protein-Protein, Protein-RNA and Protein-Ligand interactions, Metabolomic Studies and Fragment-Based Drug Screening in solution.<\/p>\n<p><em><span style=\"font-size: 90%\">Click image for larger view.<\/span><\/em><\/p>\n<figure id=\"attachment_2368\" class=\"thumbnail wp-caption alignnone\" style=\"width: 360px\"><a href=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-500-MHz-Spectrometer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2368\" src=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-500-MHz-Spectrometer-254x300.png\" alt=\"Bruker Avance III HD 500 MHz Spectrometer\" width=\"350\" height=\"414\" srcset=\"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-500-MHz-Spectrometer-254x300.png 254w, https:\/\/www.med.unc.edu\/csb\/nmr\/wp-content\/uploads\/sites\/910\/2019\/06\/Bruker-Avance-III-HD-500-MHz-Spectrometer.png 550w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Bruker Avance III HD 500 MHz Spectrometer<\/figcaption><\/figure>\n<h2>Scheduling Calendar<\/h2>\n\n<!-- iframe plugin v.5.2 wordpress.org\/plugins\/iframe\/ -->\n<iframe loading=\"lazy\" src=\"https:\/\/calendar.google.com\/calendar\/embed?src=1fb32eafav6f24tqpntq8s2o94%40group.calendar.google.com&#038;ctz=America%2FNew_York\" style=\"border: 0\" width=\"800\" height=\"600\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\"><\/iframe>\n\n<\/div>\n\n    <\/div>\n        \n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Please contact the director\u00a0to schedule use of NMR Laboratory Core Facility equipment and instrumentation. Clicking on the arrow to the right of each instrument below provides a description and photo, and allows you to view its scheduling calendar.<\/p>\n","protected":false},"author":22429,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2226","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/pages\/2226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/users\/22429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/comments?post=2226"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/pages\/2226\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/csb\/nmr\/wp-json\/wp\/v2\/media?parent=2226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}