{"id":2274,"date":"2019-08-19T12:06:29","date_gmt":"2019-08-19T16:06:29","guid":{"rendered":"https:\/\/www.med.unc.edu\/cvi\/?page_id=2274"},"modified":"2019-08-19T14:53:24","modified_gmt":"2019-08-19T18:53:24","slug":"project2","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/cvi\/projects-and-cores\/project2\/","title":{"rendered":"Project 2: Chlamydial Vaccine Testing in Mice and Guinea Pigs"},"content":{"rendered":"
Principal Investigators: Nilu Goonetilleke, PhD, and Kenneth Beagley, PhD<\/h5>\n
Co-Investigators: Toni Darville, MD, Jonathan Harris, PhD, and Alison Carey, PhD<\/h5>\n

The goal of this project is to generate novel chlamydial vaccines that will be comprehensively tested for immunogenicity, safety and protective efficacy in two pre-clinical models. Studies in mice and guinea pigs have demonstrated that induction of Chlamydia-specific CD4 T cells in genital mucosa, either by infection or through vaccination, correlates with protection. More recently, tissue-resident CD4 T cells have been shown to be critical mediators of long-term chlamydial immunity in mice. These findings support our premise that CD4 Th1 and TRM are essential to mediating CT protection. This project will identify novel chlamydial vaccines with a highly feasible path to clinical testing.<\/p>\n","protected":false},"excerpt":{"rendered":"

Principal Investigators: Nilu Goonetilleke, PhD, and Kenneth Beagley, PhD Co-Investigators: Toni Darville, MD, Jonathan Harris, PhD, and Alison Carey, PhD The goal of this project is to generate novel chlamydial vaccines that will be comprehensively tested for immunogenicity, safety and protective efficacy in two pre-clinical models. Studies in mice and guinea pigs have demonstrated that … Read more<\/a><\/p>\n","protected":false},"author":79819,"featured_media":0,"parent":2251,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2274","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nProject 2: Chlamydial Vaccine Testing in Mice and Guinea Pigs - UNC Chlamydia Vaccine Initiative<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/cvi\/projects-and-cores\/project2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Project 2: Chlamydial Vaccine Testing in Mice and Guinea Pigs - UNC Chlamydia Vaccine Initiative\" \/>\n<meta property=\"og:description\" content=\"Principal Investigators: Nilu Goonetilleke, PhD, and Kenneth Beagley, PhD Co-Investigators: Toni Darville, MD, Jonathan Harris, PhD, and Alison Carey, PhD The goal of this project is to generate novel chlamydial vaccines that will be comprehensively tested for immunogenicity, safety and protective efficacy in two pre-clinical models. 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