{"id":2342,"date":"2010-05-04T19:05:00","date_gmt":"2010-05-04T23:05:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/"},"modified":"2018-06-05T08:19:13","modified_gmt":"2018-06-05T12:19:13","slug":"dr-david-rubensteins-lab","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/","title":{"rendered":"David Rubenstein, MD, PhD Laboratories"},"content":{"rendered":"<p style=\"text-align: center;\"><strong>Epidermal Cell Biology and Molecular Mechanisms of Skin Pathology<br \/>\n<\/strong><\/p>\n<p><span style=\"text-decoration: underline;\">\u00a0<\/span><\/p>\n<table style=\"width: 566px;\" border=\"0\" cellspacing=\"1\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" title=\"Rubenstein Photo\" src=\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg\" alt=\"Rubenstein Photo\" width=\"134\" height=\"200\" \/><\/td>\n<td style=\"text-align: center;\"><a href=\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/rubenstein-publications.doc\"><span style=\"text-decoration: underline;\">Publications<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\"><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\"><\/td>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Work in the Rubenstein lab is focused on regulation cell adhesion and the inter-relationship between alterations in adhesion and the biology of the cell. This lab has made several key observations on the molecular mechanisms by which acantholysis proceeds in the human autoimmune blistering diseases pemphigus vulgaris and pemphigus foliaceus. The presence or absence of adhesion represents a major biologic shift requiring coordination amongst various biological processes, including those regulating adhesion, migration, proliferation, differentiation, and cell death. The intracellular regulatory and signalling events observed in pemphigus acantholysis likely represent variations of normal physiologic mechanisms regulating the presence\/absence of desmosome-mediated cell-cell adhesion in epidermal epithelia. The Rubenstein lab proposes that these events are important for regulating transitions in cell-adhesion and likely have a central role in adhesion transitions occuring during such processes as wound healing, tumor cell proliferation and invasion. Current projects in the lab are focused on furthering work on the mechanism of pemphigus acantholysis as well as elucidating the role of desmosomes in wound healing and cancer biology. Dr. Rubenstein is the PI for NIH R01 funding that supports these studies.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Epidermal Cell Biology and Molecular Mechanisms of Skin Pathology \u00a0 Publications Work in the Rubenstein lab is focused on regulation cell adhesion and the inter-relationship between alterations in adhesion and the biology of the cell. This lab has made several key observations on the molecular mechanisms by which acantholysis proceeds in the human autoimmune blistering &hellip; <a href=\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/\" aria-label=\"Read more about David Rubenstein, MD, PhD Laboratories\">Read more<\/a><\/p>\n","protected":false},"author":32306,"featured_media":0,"parent":2230,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2342","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>David Rubenstein, MD, PhD Laboratories | Department of Dermatology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"David Rubenstein, MD, PhD Laboratories | Department of Dermatology\" \/>\n<meta property=\"og:description\" content=\"Epidermal Cell Biology and Molecular Mechanisms of Skin Pathology \u00a0 Publications Work in the Rubenstein lab is focused on regulation cell adhesion and the inter-relationship between alterations in adhesion and the biology of the cell. This lab has made several key observations on the molecular mechanisms by which acantholysis proceeds in the human autoimmune blistering &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Dermatology\" \/>\n<meta property=\"article:modified_time\" content=\"2018-06-05T12:19:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/\",\"url\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/\",\"name\":\"David Rubenstein, MD, PhD Laboratories | Department of Dermatology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/derm\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg\",\"datePublished\":\"2010-05-04T23:05:00+00:00\",\"dateModified\":\"2018-06-05T12:19:13+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/derm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/www.med.unc.edu\/derm\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"David Rubenstein, MD, PhD Laboratories\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/derm\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/derm\/\",\"name\":\"UNC Department of Dermatology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/derm\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/derm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/derm\/#organization\",\"name\":\"UNC Department of Dermatology\",\"url\":\"https:\/\/www.med.unc.edu\/derm\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/derm\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2018\/05\/Dermatology_logo_cmyk_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2018\/05\/Dermatology_logo_cmyk_h.png\",\"width\":982,\"height\":150,\"caption\":\"UNC Department of Dermatology\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/derm\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"David Rubenstein, MD, PhD Laboratories | Department of Dermatology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/","og_locale":"en_US","og_type":"article","og_title":"David Rubenstein, MD, PhD Laboratories | Department of Dermatology","og_description":"Epidermal Cell Biology and Molecular Mechanisms of Skin Pathology \u00a0 Publications Work in the Rubenstein lab is focused on regulation cell adhesion and the inter-relationship between alterations in adhesion and the biology of the cell. This lab has made several key observations on the molecular mechanisms by which acantholysis proceeds in the human autoimmune blistering &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/","og_site_name":"Department of Dermatology","article_modified_time":"2018-06-05T12:19:13+00:00","og_image":[{"url":"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/","url":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/","name":"David Rubenstein, MD, PhD Laboratories | Department of Dermatology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/derm\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg","datePublished":"2010-05-04T23:05:00+00:00","dateModified":"2018-06-05T12:19:13+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#primaryimage","url":"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg","contentUrl":"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2017\/11\/RubensteinDave09.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/derm\/research\/dr-david-rubensteins-lab\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/derm\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/www.med.unc.edu\/derm\/research\/"},{"@type":"ListItem","position":3,"name":"David Rubenstein, MD, PhD Laboratories"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/derm\/#website","url":"https:\/\/www.med.unc.edu\/derm\/","name":"UNC Department of Dermatology","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/derm\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/derm\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/derm\/#organization","name":"UNC Department of Dermatology","url":"https:\/\/www.med.unc.edu\/derm\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/derm\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2018\/05\/Dermatology_logo_cmyk_h.png","contentUrl":"https:\/\/www.med.unc.edu\/derm\/wp-content\/uploads\/sites\/511\/2018\/05\/Dermatology_logo_cmyk_h.png","width":982,"height":150,"caption":"UNC Department of Dermatology"},"image":{"@id":"https:\/\/www.med.unc.edu\/derm\/#\/schema\/logo\/image\/"}}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/pages\/2342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/users\/32306"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/comments?post=2342"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/pages\/2342\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/pages\/2230"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/derm\/wp-json\/wp\/v2\/media?parent=2342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}