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Dr. Zanation

Harold C. Pillsbury Distinguished Professor
Vice Chairman for Academic Affairs
Director for Practice Development
Director of Advanced Rhinology, Oncology and Open/Endoscopic Skull Base Surgery Fellowship



Skull base tumors, sinonasal tumors, CSF rhinorrhea, minimally invasive head and neck tumor surgery, parotid tumors, head and neck sarcomas, rhinology, sinus sugery.


Contact Information:

  • Appointments: (984) 974-6484 opt. 2
  • Surgery Scheduler: Carla Sibrian (984) 974-2127
  • Nurse: Cherry Banares, LPN (984) 974-3523
  • Executive Assistant: Dawn Wilson (919) 843-7091



  • MD: University of North Carolina School of Medicine, 2002
  • Internship: Dept. of General Surgery, UNC School of Medicine, 2002-2003
  • Residency: Dept. of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, 2003-2007
  • Fellowship: Skull Base Oncology Program, Dept. of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, 2007-2008


Professional Experience:

  • Assistant Professor: Division of Rhinology, Allergy, and Endoscopic Skull Base Surgery; Division of Head and Neck Oncology; Dept. of Otolaryngology/Head and Neck Surgery; UNC School of Medicine; 2008-present
  • Clinical Instructor: Skull Base Oncology, Dept. of Otolaryngology/Head and Neck Surgery, Univ. of Pittsburgh Medical Center, 2007-2008


Recent Honors:

  • 2011 Triological Society Southern Section 1st Place Research Award in Head and Neck Surgery Section, January 2011, Scottsdale, AZ.
  • 2011 Triological Society Combined Section 2nd place The John E. Bordley Resident Research Award, January 2011, Scottsdale, AZ. Patel MR, Stadler ME, Deal AM, Kim HS, Shores CG, Zanation AM. STT3A, C1orf24, TFF3: Putative Markers for Characterization of Follicular Thyroid Neoplasms from Fine Needle Aspirates.
  • 2010 Triological Combined Sections Meeting 1st Place Research Award in Head and Neck Section, May 2010.
  • 2010 Triologic Society Career Development Award, May 2010
  • 2010 American Academy of Otolaryngology/Head and Neck Surgery Honor Award, May 2010
  • 2008 North American Skull Base Society Research Award, Vancouver CA, October 2008
  • 2007 UNC House Officer of the Year Award (Given to 6 out of 840 residents for outstanding patient care), May 2007
  • 2007 ANHS/AAO Young Investigator Award. $20,000 grant support. AHNS Annual Meeting, San Diego, CA, April 2007. Grant Mentors – Adam Zanation, MD and Carol Shores, MD, PhD
  • 2007 James Harrell Resident Research Award at the 2007 Southern Section Meeting, Marco Island, Fl, February 2007
  • 2006 2nd Place Resident Research Award at the 2006 Southern Section Meeting, Naples, Fl, January 2006
  • 2006 UNC Temporal Bone Dissection Award, July 2006
  • 2005 Lloyd Storrs Resident Research Award at the 2005 Southern Section Meeting, Miami, Fl, January 2005
  • 2004 First Place Resident Research Award at American Academy of Otolaryngology/Head and Neck Surgery Annual Meeting, New York, NY Sept 2004
  • Kaiser Permanente “Intern of the Year” Award – August 2003, Awarded to one surgical intern per year annually at UNC Hospitals.
  • Isaar Hall Manning Award – Awarded July 2002, One award given annually by the UNC School of Medicine for outstanding scholarship, character, leadership, initiative, and original investigative work.


Recent Publications:

  • Ang MK, Patel MR, Yin X, Sundaram S, Fritchie K, Zhao N, Liu Y, Freemerman AJ, Wilkerson MD, Walter V, Weissler MC, Shockley WW, Couch ME, Zanation AM, Hackman TG, Chera BS, Harris SL, Miller CR, Thorne L, Hayward MC, Funkhouser W, Olshan AF, Shores CG, Makowski L, Hayes DN. High XRCC1-protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2011 Sep 9. [Epub ahead of print] PubMed PMID: 21908577.
  • Al-Sheibani S, Zanation AM, Carrau RL, Prevedello DM, Prokopakis EP, McLaughlin N, Snyderman CH, Kassam AB. Endoscopic endonasal transpterygoid nasopharyngectomy. Laryngoscope. 2011 Jul 20. doi: 10.1002/lary.22165. [Epub ahead of print] PubMed PMID: 21898447.
  • Kassam AB, Prevedello DM, Carrau RL, Snyderman CH, Thomas A, Gardner P, Zanation A, Duz B, Stefko ST, Byers K, Horowitz MB. Endoscopic endonasal skull base surgery: analysis of complications in the authors’ initial 800 patients. J Neurosurg. 2011 Jun;114(6):1544-68. Epub 2010 Dec 17. PubMed PMID: 21166570.
  • Shah RN, Leight WD, Patel MR, Surowitz JB, Wong YT, Wheless SA, Germanwala AV, Zanation AM. A controlled laboratory and clinical evaluation of a three-dimensional endoscope for endonasal sinus and skull base surgery. Am J Rhinol Allergy. 2011 May;25(3):141-4. PubMed PMID: 21679524.
  • Mousa Sadr Hosseini S, Razfar A, Carrau RL, Prevedello DM, Fernandez-Miranda J, Zanation A, Kassam AB. Endonasal transpterygoid approach to the infratemporal fossa: Correlation of endoscopic and multiplanar CT anatomy. Head Neck. 2011 May 16. doi: 10.1002/hed.21725. [Epub ahead of print] PubMed PMID: 21584894.
  • Rivera-Serrano CM, Snyderman CH, Gardner P, Prevedello D, Wheless S, Kassam AB, Carrau RL, Germanwala A, Zanation A. Nasoseptal “rescue” flap: a novel modification of the nasoseptal flap technique for pituitary surgery. Laryngoscope. 2011 May;121(5):990-3. doi: 10.1002/lary.21419. PubMed PMID:21520113.
  • Patel MR, Stadler ME, Deal AM, Kim HS, Shores CG, Zanation AM. STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates. Laryngoscope. 2011 May;121(5):983-9. doi:10.1002/lary.21736. PubMed PMID: 21520112.
  • Germanwala AV, Zanaion AM. Endoscopic endonasal approach for clipping of ruptured and unruptured paraclinoid cerebral aneurysms: case report. Neurosurgery. 2011 Mar;68(1 Suppl Operative):234-9; discussion 240. PubMed PMID: 21206311.
  • Zanation AM, Carrau RL, Snyderman CH, McKinney KA, Wheless SA, Bhatki AM, Gardner PA, Prevedello DM, Kassam AB. Nasoseptal flap takedown and reuse in revision endoscopic skull base reconstruction. Laryngoscope. 2011 Jan; 121(1):42-6. PubMed PMID: 21120837.
  • Patel MR, Stadler ME, Snyderman CH, Carrau RL, Kassam AB, Germanwala AV, Gardner P, Zanation AM. How to choose? Endoscopic skull base reconstructive options and limitations. Skull Base. 2010 Nov;20(6):397-404. PubMed PMID:21772795; PubMed Central PMCID: PMC3134819.
  • McKinney KA, Snyderman CH, Carrau RL, Germanwala AV, Prevedello DM, Stefko ST, Gardner P, Kassam AB, Wheless SA, Zanation AM. Seeing the light: Endoscopic endonasal intraconal orbital tumor surgery. Otolaryngol Head Neck Surg. 2010 Nov; 143 (5) : 699-701. PubMed PMID:20974343.
  • Wheless SA, McKinney KA, Zanation AM. A prospective study of the clinical impact of a multidisciplinary head and neck tumor board. Otolaryngol Head Neck Surg. 2010 Nov; 143(5) : 650-4. PubMed PMID: 20974334.
  • McKinney KA, Stadler ME, Wong YT, Shah RN, Rose AS, Zdanski CJ, Ebert CS Jr, Wheless SA, Senior BA, Drake AF, Zanation AM. Transpalatal greater palatine canal injection: Radioanatomic analysis of where to bend the needle for pediatric sinus surgery. Am J Rhinol Allergy. 2010 Sep-Oct;24(5):385-8. PubMed PMID: 21244740; PubMed Central PMCID: PMC3076194.
  • Couch ME, Zanation AM. Transoral Robotic Surgery: Disruptive or sustaining innovation? Arch Surg. 2010 Sep; 145 (9) : 907-8. PubMed PMID: 20855763.
  • Tatreau JR, Patel MR, Shah RN, McKinney KA, Wheless SA, Senior BA, Ewend MG, Germanwala AV, Ebert CS Jr, Zanation AM. Anatomical considerations for endoscopic endonasal skull base surgery in pediatric patients. Laryngoscope. 2010 Sep;120(9):1730-7. PubMed PMID: 20717950.
  • Zanation AM, Ferlito A, Rinaldo A, Gore MR, Lund VJ, McKinney KA, Suárez C, Takes RP, Devaiah AK. When, how and why to treat the neck in patients with esthesioneuroblastoma: a review. Eur Arch Otorhinolaryngol. 2010 Nov;267(11):1667-71. Epub 2010 Aug 13. PubMed PMID: 20706843.
  • Lund VJ, Stammberger H, Nicolai P, Castelnuovo P, Beal T, Beham A, Bernal-Sprekelsen M, Braun H, Cappabianca P, Carrau R, Cavallo L, Clarici G, Draf W, Esposito F, Fernandez-Miranda J, Fokkens W, Gardner P, Gellner V, Hellquist H, Hermann P, Hosemann W, Howard D, Jones N, Jorissen M, Kassam A, Kelly D, Kurschel-Lackner S, Leong S, McLaughlin N, Maroldi R, Minovi A, Mokry M, Onerci M, Ong YK, Prevedello D, Saleh H, Sehti DS, Simmen D, Snyderman C, Solares A, Spittle M, Stamm A, Tomazic P, Trimarchi M, Unger F, Wormald PJ, Zanation A; European Rhinologic Society Advisory Board on Endoscopic Techniques in the Management of Nose, Paranasal Sinus and Skull Base Tumours. European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinol Suppl. 2010 Jun 1;(22):1-143. PubMed PMID: 20502772.
  • Patel MR, Shah RN, Snyderman CH, Carrau RL, Germanwala AV, Kassam AB, Zanation AM. Pericranial flap for endoscopic anterior skull-base reconstruction: clinical outcomes and radioanatomic analysis of preoperative planning. Neurosurgery. 2010 Mar;66(3):506-12; discussion 512. PubMed PMID: 20173545.
  • Prevedello DM, Kassam AB, Gardner P, Zanation A, Snyderman CH, Carrau RL. “Q-tip” retractor in endoscopic cranial base surgery. Neurosurgery. 2010 Feb;66(2):363-6; discussion 366-7. PubMed PMID: 20087137.
  • Gore MR, Zanation AM. Salvage treatment of late neck metastasis in esthesioneuroblastoma: a meta-analysis. Arch Otolaryngol Head Neck Surg. 2009 Oct;135(10):1030-4. PubMed PMID: 19841344.
  • Zanation AM, Carrau RL, Snyderman CH, Germanwala AV, Gardner PA, Prevedello DM, Kassam AB. Nasoseptal flap reconstruction of high flow intraoperative cerebral spinal fluid leaks during endoscopic skull base surgery. Am J Rhinol Allergy. 2009 Sep-Oct;23(5):518-21. PubMed PMID: 19807986.
  • Beahm DD, Peleaz L, Nuss DW, Schaitkin B, Sedlmayr JC, Rivera-Serrano CM, Zanation AM, Walvekar RR. Surgical approaches to the submandibular gland: a review of literature. Int J Surg. 2009 Dec;7(6):503-9. Epub 2009 Sep 24. Review. PubMed PMID: 19782158.
  • Prevedello DM, Barges-Coll J, Fernandez-Miranda JC, Morera V, Jacobson D, Madhok R, dos Santos MC, Zanation A, Snyderman CH, Gardner P, Kassam AB, Carrau R. Middle turbinate flap for skull base reconstruction: cadaveric feasibility study. Laryngoscope. 2009 Nov;119(11):2094-8. PubMed PMID: 19718761.
  • Patel MR, Bryson PC, Shores CG, Hart CF, Thorne LB, Deal AM, Zanation AM. Trefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray. Arch Otolaryngol Head Neck Surg. 2009 Jun;135(6):590-6. PubMed PMID: 19528408.
  • Shah RN, Surowitz JB, Patel MR, Huang BY, Snyderman CH, Carrau RL, Kassam AB, Germanwala AV, Zanation AM. Endoscopic pedicled nasoseptal flap reconstruction for pediatric skull base defects. Laryngoscope. 2009 Jun;119(6):1067-75. PubMed PMID: 19418531.
  • de Almeida JR, Zanation AM, Snyderman CH, Carrau RL, Prevedello DM, Gardner PA, Kassam AB. Defining the nasopalatine line: the limit for endonasal surgery of the spine. Laryngoscope. 2009 Feb;119(2):239-44. PubMed PMID: 19172603.
  • Zanation AM, Snyderman CH, Carrau RL, Gardner PA, Prevedello DM, Kassam AB. Endoscopic endonasal surgery for petrous apex lesions. Laryngoscope. 2009 Jan;119(1):19-25. PubMed PMID: 19117306.
  • Zanation AM, Snyderman CH, Carrau RL, Kassam AB, Gardner PA, Prevedello DM. Minimally invasive endoscopic pericranial flap: a new method for endonasal skull base reconstruction. Laryngoscope. 2009 Jan;119(1):13-8. PubMed PMID: 19117286.
  • Ebert CS Jr, Zanation AM, Buchman CA. Another cause for conductive hearing loss with present acoustic reflexes. Laryngoscope. 2008 Nov;118(11):2059-61. PubMed PMID: 18758374.
  • PC Bryson, MR Patel, CF Shores, CF Hart, L Thorne, ME Couch, A Farag, AM Zanation. Immunohistochemical Distinction of Follicular Adenoma versus Follicar Thyroid Carcinoma. Archives of Otolaryngology Head and Neck Surgery. 2008 Jun; 134 (6): 581-6.
  • Snyderman CH, Carrau RL, Kassam AB, Zanation AM, Prevedello D, Gardner P, Mintz A. Endoscopic Skull Base Surgery: Principles of Endonasal Oncological Surgery. Journal of Surgical Oncology. 2008 Jun 15; 97(8): 658-64.
  • George J, Cannon T, Lai V, Richey L, Zanation A, Neil Hayes D, Shores C, Guttridge D, Couch M. Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology. Head Neck. 2007 May;29(5):497-507.
  • Couch M, Lai V, Cannon T, Guttridge D, Zanation A, George J, Hayes DN, Zeisel S, Shores C. Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment. Head Neck. 2007 Apr;29(4):401-11.
  • Zanation AM and Senior BS. Transnasal Endoscopic Pituitary Surgery (Chapter). Rhinologic and Sleep Apnea Surgical Techniques. Publisher: Springer (April, 2007)
  • Richey LM, Olshan AF, George J, Shores CG, Zanation AM, Cannon T, Weissler MC. Incidence and survival rates for young blacks with nasopharyngeal carcinoma in the United States. Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1035-40.
  • Chung CH, Parker JS, Ely K, Carter J, Yi Y, Murphy BA, Ang KK, El-Naggar AK, Zanation AM, Cmelak AJ, Levy S, Slebos RJ, Yarbrough WG. Gene Expression Profiles Identify Epithelial-to-Mesenchymal Transition and Activation of Nuclear Factor-{kappa}B Signaling as Characteristics of a High-risk Head and Neck Squamous Cell Carcinoma. Cancer Res. 2006 Aug 15;66(16):8210-8218
  • Cannon T, Zanation AM, Lai V, Weissler MC. Nasopharyngeal carcinoma in young patients: a systematic review of racial demographics. Laryngoscope. 2006 Jun;116(6):1021-6.
  • Moss JR, Zanation AM, Shores CG. ACE Inhibitor Associated Recurrent Intermittent Parotid Gland Swelling. Otolaryngol Head Neck Surg. 2005 Dec;133(6):992-4.
  • Zanation AM and Senior BA. The Relationship between Extraesophageal Reflux (EER) and Obstructive Sleep Apnea (OSA). Sleep Medicine Reviews. 2005 July.
  • Zanation AM, Sutton DK, Couch ME, Weissler MC, Shockley WW, Shores CG. Utilization, Accuracy, and Implications for Patient Management of [18F]-2-Fluorodeoxyglucose-Positron Emission/Computerized Tomography (PET/CT) for Head and Neck Tumors. Laryngoscope. 2005 June; 115(6).
  • Zanation AM, Ebert CS Jr, Coffey CS, Dubin MG, Rose AS. Precursor B-cell lymphoblastic lymphoma presenting as an isolated external ear swelling in a two-year-old child. International Journal of Pediatric Otorhinolaryngology. 2005 May;69(5):695-9.