Associate Professor

Clinical research in head and neck and lung cancer; clinical application of genomic testing; cancer therapeutics and chemotherapy


  • MD, University of North Carolina, Chapel Hill, NC, 1996
  • MPH, Harvard University, 1997

Professional Experience

  • Associate Professor, Division of Hematology/Oncology, Dept. of Otolaryngology/Head and Neck Caner Surgery, University of North Carolina, Chapel Hill, NC, 2010 – Present
  • Assistant professor, Dept. of Otolaryngology/Head and Neck Cancer Surgery, University of North Carolina, Chapel Hill, NC, 2009 – 2010
  • Director of Clinical Bioinformatics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 2006 – Present
  • Director Chapel Hill Tumor Registry, University of North Carolina, Chapel Hill, NC, 2006 – Present
  • Assistant Professor of Medicine, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC, 2004 – 2010
  • Clinical Care Research Fellow, Tufts New England Medical Center, Boston, MA, 2001 – 2004
  • Instructor and Fellow, Hematology/Oncology, tufts New England Medical Center, Boston, MA, 2001 – 2004
  • Teaching Associate, Intern and Resident, Internal Medicine, Boston University School of Medicine, Boston, MA, 199 – 2000
  • High School English Teacher, LeMans, France, 1991 – 1992

Recent Publications

  • Hayes DN (one of approximately 100 listed and unordered contributors). Integrated genomic analyses of ovarian carcinoma. Cancer Genome Atlas Research Network. Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166. PMID:21720365
  • Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T, Hayes DN, Shores C, Chera BS.Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol. 2011 Apr 10;29(11):1488-94. Epub 2011 Mar 7. PMID:21383286
  • Fried D, Khandani A, Shores C, Weissler M, Hayes N, Hackman T, Rosenman J, Chera BS. Matched cohort analysis of the effect of pretreatment positron emission tomography on clinical outcomes of patients with head and neck cancer treated with definitive chemoradiotherapy. Head Neck. 2011 Aug 18. doi: 10.1002/hed.21745. PMID:21853498
  • Richards KL, Zhang B, Sun M, Dong W, Churchill J, Bachinski LL, Wilson CD, Baggerly KA, Yin G, Hayes DN, Wistuba II, Krahe R. Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers. Cancer. 2011 Feb 1;117(3):606-17. PMID: 20945327
  • Yin X, Hayes DN, Shores CG. Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma. Head Neck. 2010 Oct 21. PMID: 20967867
  • Wilkerson MD, Yin X, Hoadley KA, Liu Y, Hayward MC, Cabanski CR, Muldrew K, Miller CR, Randell SH, Socinski MA, Parsons AM, Funkhouser WK, Lee CB, Roberts PJ, Thorne L, Bernard PS, Perou CM, Hayes DN. Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. Clin Cancer Res. 2010 Oct 1;16(19):4864-75. PMID: 20643781
  • Davies JM, Dhruva NS, Walko CM, Socinski MA, Bernard S, Hayes DN, Kim WY, Ivanova A, Keller K, Hilbun LR, Chiu M, Dees EC, Stinchcombe TE. A phase I trial of sorafenib combined with cisplatin/etoposide or carboplatin/pemetrexed in refractory solid tumor patients. Lung Cancer. 2011 Feb;71(2):151-5. Epub 2010 Jul 1.PMID: 20580118
  • Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes DN, Kim WY, Engelman JA, Wong KK. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell. 2010 Jun 15;17(6):547-59. PMID: 20541700