{"id":3296,"date":"2019-03-26T14:22:17","date_gmt":"2019-03-26T18:22:17","guid":{"rendered":"https:\/\/www.med.unc.edu\/ent\/?post_type=directory&#038;p=3296"},"modified":"2026-02-13T15:57:52","modified_gmt":"2026-02-13T20:57:52","slug":"wendell-g-yarbrough-md-mmhc-facs","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/ent\/directory\/wendell-g-yarbrough-md-mmhc-facs\/","title":{"rendered":"Wendell G. Yarbrough, MD, MMHC, FACS"},"content":{"rendered":"<h4><strong>Specialty:\u00a0<\/strong><\/h4>\n<p>Head and neck surgery, cancer cell biology.<\/p>\n<h4><strong>Contact Information:<\/strong><\/h4>\n<ul>\n<li>Appointment Scheduler: (984) 974-0000<\/li>\n<li>Surgery Scheduler: Marsela Cuellar (984) 974-6337<\/li>\n<li>Executive Assistant: Tera Mincey (919) 843-7091<\/li>\n<\/ul>\n<h4><strong>Education:<\/strong><\/h4>\n<ul>\n<li>MD: University of North Carolina School of Medicine, 1985-1989<\/li>\n<li>Internship: Department of General Surgery, University of North Carolina Hospitals, 1989-1990<\/li>\n<li>Residency: Department of Otolaryngology\/Head and Neck Surgery, University of North Carolina Hospitals, 1990-1994<\/li>\n<li>Fellowship: Surgical Oncology, Department of Surgery, University of North Carolina Hospitals, 1994-1996<\/li>\n<li>MMHC: Vanderbilt Owen Graduate School of Management, 2009-2010<\/li>\n<li>A. Privatim, Honorary Master of Arts, Yale University, 2017<\/li>\n<\/ul>\n<h4><strong>Professional Experience:<\/strong><\/h4>\n<ul>\n<li>Chair, Department of Otolaryngology\/Head and Neck Surgery,\u00a0University of North Carolina at Chapel Hill School of Medicine, 2018-present<\/li>\n<li>Thomas J. Dark Distinguished Professor of Otolaryngology\/Head and Neck Surgery, 2018-present<\/li>\n<li>Professor: Department of Otolaryngology\/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, 2018-present<\/li>\n<\/ul>\n<ul>\n<li>Professor: Department of Pathology, Yale School of Medicine, 2013-2018<\/li>\n<li>Section Chief: Section of Otolaryngology, Department of Surgery, Yale School of Medicine, 2012-2018<\/li>\n<li>Professor, Otolaryngology: Department of Surgery, Yale School of Medicine, 2012-2018<\/li>\n<li>Director: Head and Neck Disease Center, Smilow Cancer Hospital, 2012-2018<\/li>\n<li>Co-Director: Virus and Other Infection-associated Cancers (VOIC) Program, Yale Cancer Center, 2012-2018<\/li>\n<li>Professor with Tenure: Department of Otolaryngology, Vanderbilt University, 2012-2012<\/li>\n<li>Barry and Amy Baker Chair in Laryngeal, Head and Neck Research, Vanderbilt University, 2012-2012<\/li>\n<li>Co-leader, Thoracic and Head &amp; Neck Program, Vanderbilt Ingram Cancer Center, 2009-2012<\/li>\n<li>Adjunct Associate Professor Surgery, Meharry Medical College, 2008-2012<\/li>\n<li>Ingram Professor of Cancer Research, Vanderbilt Ingram Cancer Center, Vanderbilt University, 2006-2012<\/li>\n<li>Associate Professor with Tenure, Otolaryngology, Vanderbilt University, 2003-2012<\/li>\n<li>Associate Professor with Tenure, Cancer Biology, Vanderbilt University, 2003-2012<\/li>\n<li>Director, Barry Baker Laboratory of Head and Neck Oncology, Department of Otolaryngology, Vanderbilt University, 2003-2012<\/li>\n<li>Chief Otolaryngology, VA Medical Center, 2003-2004<\/li>\n<li>Co-director, Otolaryngology\/Head and Neck Resident Curriculum, University of North Carolina at Chapel Hill, 2002-2003<\/li>\n<li>Assistant Professor, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 2001-2001<\/li>\n<li>Associate Professor with Tenure, Otolaryngology\/Head and Neck Surgery, University of North Carolina at Chapel Hill, 2001-2003<\/li>\n<li>Associate Professor with Tenure, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 2001-2003<\/li>\n<li>Associate Professor with Tenure, Biochemistry &amp; Biophysics, University of North Carolina at Chapel Hill, 2001-2003<\/li>\n<li>Assistant Professor, Biochemistry &amp; Biophysics, University of North Carolina at Chapel Hill, 2000-2001<\/li>\n<li>Assistant Professor, Otolaryngology\/Head and Neck Surgery, University of North Carolina at Chapel Hill, 1996-2001<\/li>\n<\/ul>\n<h4><strong>Honors:<\/strong><\/h4>\n<ul>\n<li>2016-2018 \u201cAmerica\u2019s Top Doctors for Cancer,\u201d Executive List, Castle Connolly<\/li>\n<li>2009-2018 \u201cAmerica\u2019s Top Doctors,\u201d Editions 8-14, Castle Connolly<\/li>\n<li>2005-2018 \u201cAmerica\u2019s Top Doctors for Cancer,\u201d Editions, Castle Connolly<\/li>\n<li>2015 \u201cTop Doctors for Cancer,\u201d Newsweek Magazine<\/li>\n<li>2014 Presidential Citation, AHNS, American Head and Neck Society<\/li>\n<li>2014 \u201cAmerica\u2019s Top Doctors \u2013 New York Metro Area,\u201d Edition 17, Castle Connolly<\/li>\n<li>2011 5-star Patient Satisfaction Awards for Overall Quality of Doctor Care<\/li>\n<li>Given for achieving overall quality of care in the 90th-99th percentile<\/li>\n<li>Professional Research Consultants (PRC) in Omaha, NE<\/li>\n<li>2010 \u201cAmerica\u2019s Top Physicians\u201d, Consumers\u2019 Research Council of America &amp; SLD Industries, Inc.<\/li>\n<li>2004 Distinguished Service Award in Scientific Programs, Exhibits, Continuing Education Courses and Instructional Course, American Academy of Otolaryngology-Head and Neck Surgery Foundation<\/li>\n<li>2002 Harris P. Mosher Award, Recognizing excellence in clinical research, The American Laryngological, Rhinological and Otological Society<\/li>\n<li>2000 Jefferson Pilot Fellowship, Recognizing the outstanding Assistant Professor in the School of Medicine<\/li>\n<li>1994 The American Laryngological, Rhinological, and Otological Society, Inc., Resident Research Award, 1st prize<\/li>\n<li>1994 Nathan A. Womack Scholar, Recognizing the outstanding surgical resident<\/li>\n<li>1991- 1992 Newton D. Fischer Society Temporal Bone Dissection Award<\/li>\n<li>1989 Michiko Kuno Award for Best Presentation of John B. Graham, Student Research Society<\/li>\n<li>1989 Graduated with Honors and Distinction, University of North Carolina School of Medicine<\/li>\n<li>1989 Deborah C. Leary Award, For the outstanding medical student research paper<\/li>\n<li>1988 Alpha Omega Alpha<\/li>\n<li>1986-1989 Academic Honors, Medical School<\/li>\n<li>1985 Phi Lambda Upsilon (Honorary Chemical Society)<\/li>\n<li>1985 Student Research &amp; Recognition Foundation Award, Recognition for outstanding Senior Student Majoring in Chemistry<\/li>\n<li>1985 Graduated with Honors in Chemistry<\/li>\n<li>1981-1985 John Motley Morehead Scholarship<\/li>\n<li>1984 Phi Beta Kappa<\/li>\n<li>1982 Phi Eta Sigma (Freshman Honor Society)<\/li>\n<\/ul>\n<h4><strong>Recent Publications:<\/strong><\/h4>\n<p>For a complete list of recent publications, please visit <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wendell+G.+Yarbrough\">Dr. Yarbrough&#8217;s PubMed page<\/a>.<\/p>\n<div class=\"entry-content-asset\"><iframe loading=\"lazy\" title=\"Meet Wendell G. Yarbrough, MD\" width=\"1140\" height=\"641\" src=\"https:\/\/www.youtube.com\/embed\/tMGXtwppdsY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<h4><strong>Active Grants:<\/strong><\/h4>\n<p>Title: Head and Neck Cancer SPORE: Overcoming Treatment Resistance in Head and Neck Cancer (a multi-project award)<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project Number: P50-DE030707(NIH); CON80003835(GR116824) (Yale Univ.)<span class=\"Apple-converted-space\"><br \/>\n<\/span>Name of PD\/PI: Barbara Burtness (Yale); Wendell Yarbrough (UNC)<span class=\"Apple-converted-space\"><br \/>\n<\/span>Source of Support: NIH NCI NIDCR; Yale University<span class=\"Apple-converted-space\"><br \/>\n<\/span>Primary Place of Performance: The University of North Carolina at Chapel Hill<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project\/Proposal Start and End Date: (MM\/YYYY) (if available): 09\/22\/2020 \u2013 06\/30\/2025<span class=\"Apple-converted-space\"><br \/>\n<\/span>Total Award Amount (including Indirect Costs): $487,319<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>Title: Exploring mechanisms of therapeutic demethylation effects in HPV-associated head and neck cancer<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project Number: R01-DE027942<span class=\"Apple-converted-space\"><br \/>\n<\/span>Name of PD\/PI: Wendell Yarbrough<span class=\"Apple-converted-space\"><br \/>\n<\/span>Source of Support: NIH National Institute of Dental &amp; Craniofacial Research<span class=\"Apple-converted-space\"><br \/>\n<\/span>Primary Place of Performance: The University of North Carolina at Chapel Hill<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project\/Proposal Start and End Date: (MM\/YYYY) (if available): 06\/01\/2019 \u2013 07\/31\/2024<span class=\"Apple-converted-space\"><br \/>\n<\/span>Total Award Amount (including Indirect Costs): $2,102,023<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>Title: Dissecting NF-kB pathway in HPV-associated head and neck cancer<span class=\"Apple-converted-space\">\u00a0<\/span><span class=\"Apple-converted-space\"><br \/>\n<\/span>Project Number: R01-DE031297<span class=\"Apple-converted-space\"><br \/>\n<\/span>Name of PD\/PI: Wendell Yarbrough<span class=\"Apple-converted-space\"><br \/>\n<\/span>Source of Support: NIH National Institute of Dental and Cran<span class=\"Apple-converted-space\"><br \/>\n<\/span>Primary Place of Performance: The University of North Carolina at Chapel Hill<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project\/Proposal Start and End Date: (MM\/YYYY) (if available): 03\/01\/2023 \u2013 12\/31\/2027<span class=\"Apple-converted-space\"><br \/>\n<\/span>Total Award Amount (including Indirect Costs): $2,565,330<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>Title: From Basic Science to Clinical Application: Developing a Clinical Assay to Guide Patient Therapy in HPV-Associated Head and Neck Cancer<br \/>\nProject Number: 2023-FLG-0049<span class=\"Apple-converted-space\"><br \/>\n<\/span>Name of PD\/PI: Wendell Yarbrough<span class=\"Apple-converted-space\"><br \/>\n<\/span>Source of Support: North Carolina Biotechnology Center<span class=\"Apple-converted-space\"><br \/>\n<\/span>Primary Place of Performance: The University of North Carolina at Chapel Hill<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project\/Proposal Start and End Date: (MM\/YYYY) (if available): 07\/01\/2023 \u2013 06\/30\/2024<span class=\"Apple-converted-space\"><br \/>\n<\/span>Total Award Amount (including Indirect Costs): $20,000<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>Title: Observational study to validate HPV DNA genotyping and prognostic genomic biomarkers for diagnosis and treatment of HPV-associated HNSCC<span class=\"Apple-converted-space\">\u00a0<\/span><span class=\"Apple-converted-space\"><br \/>\n<\/span>Project Number: U01-DE029754<span class=\"Apple-converted-space\"><br \/>\n<\/span>Name of PD\/PI: Wendell Yarbrough<span class=\"Apple-converted-space\"><br \/>\n<\/span>Source of Support: NIH National Institute of Dental &amp; Craniofacial Research<span class=\"Apple-converted-space\"><br \/>\n<\/span>Primary Place of Performance: The University of North Carolina at Chapel Hill<span class=\"Apple-converted-space\"><br \/>\n<\/span>Project\/Proposal Start and End Date: (MM\/YYYY) (if available): 07\/01\/2020 \u2013 04\/30\/2025<span class=\"Apple-converted-space\"><br \/>\n<\/span>Total Award Amount (including Indirect Costs): $3,766,762<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4><strong>Completed Grants:<\/strong><\/h4>\n<p>Yale Comprehensive Cancer Center \u2013 Cancer Center Support Grant Supplement: Molecular and Immunologic Profile of Head and Neck Squamous Cell Cancers Among HIV-Infected Individuals. 8\/1\/2016 \u2013 8\/31\/2018;<br \/>\nPI: Wendell Yarbrough, Brinda Emu<br \/>\nDirect costs per year: $59,701 Effort: 5%<\/p>\n<p>NIH\/NCI \u2013 5P30 CA016359-37: Yale Comprehensive Cancer Center:<br \/>\n8\/1\/2007 \u2013 7\/31\/2017<br \/>\nPI: Schulman<br \/>\nTotal costs for project period: $1,561,565 Effort: 5%<br \/>\nPlexxikon, Inc.: Role of TRKC in Salivary Adenoid Cystic Carcinoma:<br \/>\n10\/01\/2014-03\/31\/2015<br \/>\nPI: Wendell Yarbrough<br \/>\nTotal costs for project period: $66,464 Effort: 1%<\/p>\n<p>NIH\/NIDCR \u2013 R21DE022641: Role of TrkC in Neurotropic Salivary Cancers:<br \/>\n09\/01\/2013-08\/31\/2015<br \/>\nP.I.: Sergey Ivanov, PhD. \/ (Co-Investigator) Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $125,000 Percent effort: 3%<br \/>\nNCI\/NIH \u2013 CCSG \u2013 P30CA016359: Head &amp; Neck Squamous Cell Carcinoma Biospecimen and Clinical Data Acquisition: 09\/01\/2013-08\/31\/2014<br \/>\nPI: Wendell Yarbrough<br \/>\nDirect costs per year: $60,059 Effort: 1%<\/p>\n<p>Yale Cancer Center \u2013 T-Tare: Divide and Conquer: Advancing Therapy for Head and Neck Squamous Cell Carcinoma:\u00a0 07\/01\/2013-06\/30\/2014<br \/>\nP.I.: Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $125,000 Percent effort: 10%, no salary<\/p>\n<p>Yale Cancer Center \u2013 Pilot Project: GABA-regulated SOX10 Signaling as a Potential Therapeutic Target in Adenoid Cystic and Breast Basal-like Carcinomas:<br \/>\n06\/01\/2013-05\/31\/2014<br \/>\nP.I.: Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $ 50,000 Percent effort: 2%, no salary<\/p>\n<p>ACCRF Grant \u2013 Role of TrkC in Neurotropic Salivary Cancers The goal of the proposal is to explore the molecular mechanisms of TrkC and NT-3 involvement in ACC to assess efficacy of Trk inhibitors as a potential therapeutic strategy:<br \/>\n02\/16\/2013-02\/15\/2014<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $14,318 Percent effort: 1%<\/p>\n<p>NIH\/NIDCR \u2013 R21DE023228: Validated Modeling and Culture of Salivary Cancers the goal of this project is to create mouse xenograft models of human salivary cancers of multiple histologies:<br \/>\n12\/01\/2012-11\/30\/2014<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $137,500 Percent effort: 5%<\/p>\n<p>NIH\/NIDCR \u2013 R01DE013173:Tumor suppressor qualities and mechanisms of LZAP activity Determine LZAP tumor suppressor qualities and describe interactions with the p53-induced phosphatase, Wip1: 12\/01\/2012-11\/30\/2016<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $250,000\u00a0\u00a0\u00a0Percent effort:\u00a0 16%<\/p>\n<p>NIH\/NIDCR Funded Extension, (CCSG) Cancer Center Support Grant- P30CA016359:The goal of this project is to support research and education to better facilitate the prevention, treatment and care of cancer related patients:<br \/>\n08\/09\/2007-07\/31\/2013<br \/>\nRole: Co-leader of Molecular Virology Program<br \/>\nP.I.:\u00a0 Thomas Lynch, MD<br \/>\nDirect costs per year:\u00a0 $2,900,000 Percent effort: 5%<\/p>\n<p>NIH\/NIDCR -R21DE018244: Cortactin in HNSCC Tumor Progression:<br \/>\n8\/01\/2007-7\/31\/2010<br \/>\nP.I.:\u00a0 Alissa Weaver, PhD. \u2013 Principal Investigator, Wendell Yarbrough, MD \u2013 Co-Investigator<br \/>\nTotal costs for project period:\u00a0 $300,000.00<br \/>\nPercent effort: 5%<\/p>\n<p>NCI \u2013 Comprehensive Minority Institution \/Cancer Center Partnership (U54, PI, Harold \u00a0\u00a0Moses) \u2013 U54CA163072: Pre-Pilot Project. Identification of serum biomarkers in HNSCC;<br \/>\n9\/1\/2006-8\/31\/2007<br \/>\nP.I.:\u00a0 Wendell G. Yarbrough, M.D. and Sabina Francis M.D., Co-Principal Investigators<br \/>\nTotal costs for project period:\u00a0 $25,000<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation Award: Biomarkers for HNSCC and Targets for Novel Therapies; 9\/1\/2006-8\/31\/2007<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $300,000<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>AAO-HNSF \u2013 Percy Memorial Research Award \u2013 American Academy of Otolaryngology-Head and Neck Surgery Foundation: Effect of PI3K inhibition in HPV-associated HNSCC<br \/>\n07\/01\/2006-06\/30\/2007<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nProject period:\u00a0 $25,000.<br \/>\nPercent effort: 2%, no salary<\/p>\n<p>THANC \u2013 Thyroid, Head and Neck Cancer Foundation, Senior Investigator Award-Head and Neck Cancer Research: Serum biomarkers for head &amp; neck cancer;<br \/>\n7\/1\/2005 renewable yearly through 6\/30\/2009<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $50,000<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>NIH\/NIDCR \u2013 R01DE013173: Novel protein regulator of tumor suppressor ARF &amp; NF-kB;<br \/>\n5\/1\/2005-4\/31\/2010<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $1,250,000<br \/>\nPercent effort: 5%<\/p>\n<p>Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation Award: Proteome Profiling of Human Serum<br \/>\nProject period:\u00a0 7\/1\/2005-6\/30\/2006<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $50,000<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>ACOSOG \u2013 American College of Surgeons Oncology Group: A trial of lymphatic mapping and sentinel node lymphadenectomy for patients with T1 or T2 clinically N0 oral cavity squamous cell carcinoma<br \/>\nProject period:\u00a0 1\/1\/2004 \u2013 5\/31\/2006<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD \u2013 Vanderbilt University. Institutional Principal<br \/>\nPercent effort: 3%, no salary<\/p>\n<p>NIH\/NCI-R21CA102161: Gene Expression as a Predictor of Metastasis in HNSCC<br \/>\nProject period:\u00a0 7\/01\/2003-6\/30\/2005<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $200,000<br \/>\nPercent effort: 5%<\/p>\n<p>ACOSOG \u2013 American College of Surgeons Oncology Group: A trial of lymphatic mapping and sentinel node lymphadenectomy for patients with T1 or T2 clinically N0 oral cavity squamous cell carcinoma<br \/>\nProject period:\u00a0 2\/1\/2002 \u2013 4\/30\/2003<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>Medical Alumni Endowment Research Grant:\u00a0 Pre-clinical Studies of Tumor Suppressor ARF in Organotypic Raft Modeled Head and Neck Cancer<br \/>\nProject period: 6\/1\/2001-5\/31\/2002<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD \u2013 Mentor. Adam M. Zanation<br \/>\nTotal costs for project period:\u00a0 $2,000<br \/>\nPercent effort: 2%, no salary<\/p>\n<p>Alpha Omega Alpha Research Fellowship- Alpha Omega Alpha National Medical Honor Society:\u00a0 ARF armed oncolytic viral therapy for head and neck cancer:\u00a0 preclinical studies<br \/>\nProject period:\u00a0 4\/1\/2001-4\/1\/2002<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD \u2013 Adam M. Zanation, Recipient<br \/>\nTotal costs for project period:\u00a0 $3,500<br \/>\nPercent effort: 2%, no salary<\/p>\n<p>Scott Neil Schwirck Fellowship \u2013 UNC School of Medicine:\u00a0 Preclinical studies of ARF tumor suppressor therapy for head and neck cancer<br \/>\nProject period:\u00a0 1\/1\/2001\u20131\/01\/2002<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $2,500<br \/>\nPercent effort: 2%, no salary<\/p>\n<p>University Research Council \u2013 University of North Carolina: Development of a Smoking Prevention Video targeting middle school age children<br \/>\nProject period:\u00a0 1\/2000-12\/2001<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD, Carol G. Shores, M.D., Ph.D<br \/>\nTotal costs for project period:\u00a0 $10,000<br \/>\nPercent effort: 3%, no salary<\/p>\n<p>University Research Council \u2013 University of North Carolina \u2013 Cancer Prevention Program:\u00a0 A Controlled Study of the Effectiveness of a Smoking and Alcohol Prevention Video and Presentation Relating to Head and Neck Cancer in Middle School Students<br \/>\nProject period:\u00a0 1\/2000-12\/2001<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD, Adam M. Zanation, Carol G. Shores, M.D., Ph.D<br \/>\nTotal costs for project period:\u00a0 $4,000<br \/>\nPercent effort: 3%, no salary<\/p>\n<p>National Institute of Dental and Craniofacial Research-R01DE013173:ARF as a therapeutic agent in oral malignancies.<br \/>\nProject period:\u00a0 4\/1\/2000-3\/31\/2004<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period:\u00a0 $998,320<br \/>\nPercent effort: 2%<\/p>\n<p>The American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc AAO-HNS Foundation Resident Research Grant:\u00a0Cytokeratins as Molecular Markers for Head and Neck Cancer<br \/>\nProject period:\u00a0 7\/1\/2000-6\/30\/2001<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD \u2013 Mentor.\u00a0 Marta K. Taylor, Recipient<br \/>\nTotal costs for project period: $10,000<br \/>\nPercent effort: 2%, no salary<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>Active Clinical Trials: \u00a0<\/strong><\/h4>\n<p>Fox Chase Cancer Center-1407014279: Phase II trial of carboplatin\/paclitaxel and cetuximab, followed by<br \/>\ncarboplatin\/paclitaxel\/cetuximab and erlotinib, with correlative studies in patients with<br \/>\nmetastatic or recurrent squamous cell carcinoma of the head and neck<br \/>\nP.I:\u00a0\u00a0 Barbara Burtness, MD<br \/>\nDirect costs per year: N\/A<br \/>\nProject period: March 16, 2011-Current<br \/>\nEffort: 2%, no salary<\/p>\n<p>Yale University Investigator Initiated Trial \u2013 1404013771: Window study to assess the activity of demethylation therapy in patients with HPV positive compared with HPV negative HNSCC.<br \/>\nP.I:\u00a0Wendell Yarbrough, MD &amp; Hari Deshpande, MD<br \/>\nDirect costs per year: N\/A<br \/>\nProject period: June 30, 1994-Current<br \/>\nEffort: 5%, no salary<\/p>\n<p>Eastern Cooperative Oncology Group-1403013536: ECOG 3311: Phase II Randomized Trial of Transoral Surgical Resection Followed by Low-dose or Standard-dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer<br \/>\nP.I:\u00a0\u00a0 Benjamin Judson, MD<br \/>\nRole on project: Co-Investigator<br \/>\nTotal costs for project period: N\/A<br \/>\nProject period:\u00a0 August 1, 2013-February 28, 2023<br \/>\nPercent effort: 1%, no salary<\/p>\n<h4><strong>Completed Clinical Trials:<\/strong><\/h4>\n<p>AbbVie (Abbott Pharmaceuticals) \u2013 Investigator initiated Pre-Clinical Study: PARP inhibition as a molecular therapeutic strategy to treat a subset of HNSCC:<br \/>\nP.I.: Wendell Yarbrough, MD<br \/>\nDirect costs per year:\u00a0 $30,000<br \/>\nProject Period: : 08\/01\/2013-02\/01\/2014<br \/>\nEffort: 5%, no salary<\/p>\n<p>NIH \u2013 Clinical Trial, Lead Site at University of Pittsburgh \u2013 Related to RC1 Grant: Comparison of biomarker modulation by inhibition of EGFR and\/or src Family kinases using Erlotinib and Dasatinib in head and neck and lung cancers:<br \/>\nP.I.:\u00a0 Jennifer Grandis, MD<br \/>\nRole on Project:\u00a0 Institutional Principal Investigator, Vanderbilt University<br \/>\nProject Period-03\/01\/2010 to 03\/01\/2013<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>Onyx Pharmaceuticals: An open label, single arm study of intratumoral ONYX-015 plus<br \/>\nIntravenous cisplatin\/5-FU inpatients with squamous cell carcinoma of the<br \/>\nhead and neck (SCCHN) refractory to cisplatin\/5 FU<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period: N\/A<br \/>\nProject period:\u00a0 10\/1\/2002 \u2013 2\/28\/2003<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>Doris Duke Clinical Research Fellowship: ONYX 015 intratumoral phase III clinical trial and preclinical studies of ARF armed oncolytic viral therapy for head and neck cancer<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD \u2013 Mentor. Adam M. Zanation<br \/>\nTotal costs for project period:\u00a0 $25,000<br \/>\nProject period:\u00a0 6\/1\/2001- 5\/30\/2002<br \/>\nPercent effort: 5%, no salary<\/p>\n<p>Pfizer\/ONYX Pharmaceuticals:\u00a0 A randomized phase 3 trial of intratumoral injection of CI-1042 (ONYX015) plus intravenous cisplatin\/5-fluorouracil versus intravenous cisplatin\/5-fluorouracil alone in patients with recurrent squamous cell carcinoma of the head and neck (protocol 1042-001)<br \/>\nP.I.:\u00a0 Wendell Yarbrough, MD<br \/>\nTotal costs for project period: N\/A<br \/>\nProject period:\u00a0 11\/1\/2000 \u2013 2\/28\/2003<br \/>\nPercent effort: 5%, no salary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Specialty:\u00a0 Head and neck surgery, cancer cell biology. Contact Information: Appointment Scheduler: (984) 974-0000 Surgery Scheduler: Marsela Cuellar (984) 974-6337 Executive Assistant: Tera Mincey (919) 843-7091 Education: MD: University of North Carolina School of Medicine, 1985-1989 Internship: Department of General Surgery, University of North Carolina Hospitals, 1989-1990 Residency: Department of Otolaryngology\/Head and Neck Surgery, University &hellip; <a href=\"https:\/\/www.med.unc.edu\/ent\/directory\/wendell-g-yarbrough-md-mmhc-facs\/\" aria-label=\"Read more about Wendell G. Yarbrough, MD, MMHC, FACS\">Read more<\/a><\/p>\n","protected":false},"featured_media":7665,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-3296","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Wendell G. Yarbrough, MD, MMHC, FACS | UNC Otolaryngology\/Head and Neck Surgery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/ent\/directory\/wendell-g-yarbrough-md-mmhc-facs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wendell G. Yarbrough, MD, MMHC, FACS | UNC Otolaryngology\/Head and Neck Surgery\" \/>\n<meta property=\"og:description\" content=\"Specialty:\u00a0 Head and neck surgery, cancer cell biology. Contact Information: Appointment Scheduler: (984) 974-0000 Surgery Scheduler: Marsela Cuellar (984) 974-6337 Executive Assistant: Tera Mincey (919) 843-7091 Education: MD: University of North Carolina School of Medicine, 1985-1989 Internship: Department of General Surgery, University of North Carolina Hospitals, 1989-1990 Residency: Department of Otolaryngology\/Head and Neck Surgery, University &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/ent\/directory\/wendell-g-yarbrough-md-mmhc-facs\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Otolaryngology\/Head and Neck Surgery\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T20:57:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/ent\/wp-content\/uploads\/sites\/494\/2019\/03\/NDFHeadshot-6-copy-scaled-e1736388166783.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1553\" \/>\n\t<meta property=\"og:image:height\" content=\"1562\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@UNC_ENT\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"11 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/ent\/directory\/wendell-g-yarbrough-md-mmhc-facs\/\",\"url\":\"https:\/\/www.med.unc.edu\/ent\/directory\/wendell-g-yarbrough-md-mmhc-facs\/\",\"name\":\"Wendell G. 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