{"id":16826,"date":"2022-10-18T16:36:53","date_gmt":"2022-10-18T20:36:53","guid":{"rendered":"https:\/\/www.med.unc.edu\/fammed\/?page_id=16826"},"modified":"2022-10-18T16:36:53","modified_gmt":"2022-10-18T20:36:53","slug":"first-episodes-of-norovirus-and-sapovirus-gastroenteritis-protect-against-subsequent-episodes-in-a-nicaraguan-birth-cohort","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/first-episodes-of-norovirus-and-sapovirus-gastroenteritis-protect-against-subsequent-episodes-in-a-nicaraguan-birth-cohort\/","title":{"rendered":"First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort"},"content":{"rendered":"<p><span style=\"font-size: 18pt;color: #333399\">Authors<\/span><\/p>\n<p><strong>Nadja A Vielot<\/strong>, Yaoska Reyes, Bryan Blette, Fredman Gonz\u00e1lez, Christian Toval-Ruiz, Lester Guti\u00e9rrez, Samuel Vilchez, Marta Diez-Valcarce, Jan Vinj\u00e9, <strong>Sylvia Becker-Dreps<\/strong>, Filem\u00f3n Bucardo<\/p>\n<p><span style=\"font-size: 18pt;color: #333399\">Abstract<\/span><\/p>\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Norovirus and sapovirus cause a large burden of acute gastroenteritis (AGE) in young children. We assessed protection conferred by norovirus and sapovirus AGE episodes against future episodes. <strong class=\"sub-title\">Methods:\u00a0<\/strong>Between June 2017 and July 2018, we recruited 444 newborns in Le\u00f3n, Nicaragua. Weekly household surveys identified AGE episodes over 36 months, and AGE stools were tested by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) for norovirus genogroup (G)I\/GII and sapovirus. We used recurrent-event Cox models and negative control methods to estimate protection conferred by first episodes, controlling for observed and unobserved risk factors, respectively. <strong class=\"sub-title\">Results:\u00a0<\/strong>Sapovirus episodes conferred a 69% reduced hazard of subsequent episodes using the negative control method. Norovirus GI (hazard ratio [HR] = 0.67; 95% confidence interval [CI] = 0.31, 1.3) and GII (HR = 0.20; 95% CI = 0.04, 0.44) episodes also appeared highly protective. Protection against norovirus GII was enhanced following two episodes. <strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Evidence of natural immunity in early childhood provides optimism for the future success of pediatric norovirus and sapovirus vaccines.<\/p>\n<p><span style=\"font-size: 18pt;color: #333399\">Citation<\/span><\/p>\n<p><strong>Vielot NA, Reyes Y, Blette B, Gonz\u00e1lez F, Toval-Ruiz C, Guti\u00e9rrez L, Vilchez S, Diez-Valcarce M, Vinj\u00e9 J, Becker-Dreps S, Bucardo F. First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort. Epidemiology. 2022 Sep 1;33(5):650-653. doi: 10.1097\/EDE.0000000000001500. Epub 2022 Jun 10. PMID: 35700200; PMCID: PMC9378628.<\/strong><\/p>\n<p><span style=\"font-size: 18pt;color: #333399\">Publication Link<\/span><\/p>\n<p><a href=\"https:\/\/journals.lww.com\/epidem\/Abstract\/2022\/09000\/First_Episodes_of_Norovirus_and_Sapovirus.7.aspx\">Full Text<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors Nadja A Vielot, Yaoska Reyes, Bryan Blette, Fredman Gonz\u00e1lez, Christian Toval-Ruiz, Lester Guti\u00e9rrez, Samuel Vilchez, Marta Diez-Valcarce, Jan Vinj\u00e9, Sylvia Becker-Dreps, Filem\u00f3n Bucardo Abstract Background:\u00a0Norovirus and sapovirus cause a large burden of acute gastroenteritis (AGE) in young children. We assessed protection conferred by norovirus and sapovirus AGE episodes against future episodes. Methods:\u00a0Between June 2017 &hellip; <a href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/first-episodes-of-norovirus-and-sapovirus-gastroenteritis-protect-against-subsequent-episodes-in-a-nicaraguan-birth-cohort\/\" aria-label=\"Read more about First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort\">Read more<\/a><\/p>\n","protected":false},"author":63861,"featured_media":0,"parent":413,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"class_list":["post-16826","page","type-page","status-publish","hentry","category-news","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort - Department of Family Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/first-episodes-of-norovirus-and-sapovirus-gastroenteritis-protect-against-subsequent-episodes-in-a-nicaraguan-birth-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort - Department of Family Medicine\" \/>\n<meta property=\"og:description\" content=\"Authors Nadja A Vielot, Yaoska Reyes, Bryan Blette, Fredman Gonz\u00e1lez, Christian Toval-Ruiz, Lester Guti\u00e9rrez, Samuel Vilchez, Marta Diez-Valcarce, Jan Vinj\u00e9, Sylvia Becker-Dreps, Filem\u00f3n Bucardo Abstract Background:\u00a0Norovirus and sapovirus cause a large burden of acute gastroenteritis (AGE) in young children. We assessed protection conferred by norovirus and sapovirus AGE episodes against future episodes. 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