{"id":17091,"date":"2022-11-16T12:26:32","date_gmt":"2022-11-16T17:26:32","guid":{"rendered":"https:\/\/www.med.unc.edu\/fammed\/?page_id=17091"},"modified":"2022-11-16T12:26:32","modified_gmt":"2022-11-16T17:26:32","slug":"association-between-breastfeeding-host-genetic-factors-and-calicivirus-gastroenteritis-in-a-nicaraguan-birth-cohort","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/association-between-breastfeeding-host-genetic-factors-and-calicivirus-gastroenteritis-in-a-nicaraguan-birth-cohort\/","title":{"rendered":"Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort"},"content":{"rendered":"

Authors<\/span><\/p>\n

Vielot NA<\/strong>, Fran\u00e7ois R, Huseynova E, Gonz\u00e1lez F, Reyes Y, Gutierrez L, Nordgren J, Toval-Ruiz C, Vilchez S, Vinj\u00e9 J, Becker-Dreps S<\/strong>, Bucardo F.<\/p>\n

Abstract<\/span><\/p>\n

Background:\u00a0<\/strong>Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. Methods:\u00a0<\/strong>We investigated the association between breastfeeding and norovirus or sapovirus AGE episodes in a birth cohort. Weekly data on breastfeeding and AGE episodes were captured during the first year of life. Stools were collected from children with AGE and tested by RT-qPCR for norovirus and sapovirus. Time-dependent Cox models estimated associations between weekly breastfeeding and time to first norovirus or sapovirus AGE. Findings:\u00a0<\/strong>From June 2017 to July 2018, 444 newborns were enrolled in the study. In the first year of life, 69 and 34 children experienced a norovirus and a sapovirus episode, respectively. Exclusive breastfeeding lasted a median of 2 weeks, and any breastfeeding lasted a median of 43 weeks. Breastfeeding in the last week did not prevent norovirus (HR: 1.09, 95% CI: 0.62, 1.92) or sapovirus (HR: 1.00, 95% CI: 0.82, 1.21) AGE in a given week, adjusting for household sanitation, consumption of high-risk foods, and mother’s and child’s histo-blood group phenotypes. Maternal secretor-positive phenotype was protective against norovirus AGE, whereas child’s secretor-positive phenotype was a risk factor for norovirus AGE. Interpretation:\u00a0<\/strong>Exclusive breastfeeding in this population was short-lived, and no conclusions could be drawn about its potential to prevent norovirus or sapovirus AGE. Non-exclusive breastfeeding did not prevent norovirus or sapovirus AGE in the first year of life. However, maternal secretor-positive phenotype was associated with a reduced hazard of norovirus AGE.<\/p>\n

Citation<\/span><\/p>\n

Vielot NA<\/strong>, Fran\u00e7ois R, Huseynova E, Gonz\u00e1lez F, Reyes Y, Gutierrez L, Nordgren J, Toval-Ruiz C, Vilchez S, Vinj\u00e9 J, Becker-Dreps S<\/strong>, Bucardo F. Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort. PLoS One. 2022 Oct 14;17(10):e0267689. doi: 10.1371\/journal.pone.0267689. PMID: 36240197; PMCID: PMC9565698.<\/p>\n

Publication Link<\/span><\/p>\n

Full Text<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors Vielot NA, Fran\u00e7ois R, Huseynova E, Gonz\u00e1lez F, Reyes Y, Gutierrez L, Nordgren J, Toval-Ruiz C, Vilchez S, Vinj\u00e9 J, Becker-Dreps S, Bucardo F. Abstract Background:\u00a0Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. … Read more<\/a><\/p>\n","protected":false},"author":63861,"featured_media":0,"parent":413,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"class_list":["post-17091","page","type-page","status-publish","hentry","category-news","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"\nAssociation between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort - Department of Family Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/association-between-breastfeeding-host-genetic-factors-and-calicivirus-gastroenteritis-in-a-nicaraguan-birth-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort - Department of Family Medicine\" \/>\n<meta property=\"og:description\" content=\"Authors Vielot NA, Fran\u00e7ois R, Huseynova E, Gonz\u00e1lez F, Reyes Y, Gutierrez L, Nordgren J, Toval-Ruiz C, Vilchez S, Vinj\u00e9 J, Becker-Dreps S, Bucardo F. 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