{"id":17105,"date":"2022-11-16T14:52:49","date_gmt":"2022-11-16T19:52:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/fammed\/?page_id=17105"},"modified":"2022-11-16T14:52:49","modified_gmt":"2022-11-16T19:52:49","slug":"preexisting-heterotypic-ligand-blocking-antibody-does-not-protect-against-genogroup-ii-norovirus-episodes-in-young-children-2","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/preexisting-heterotypic-ligand-blocking-antibody-does-not-protect-against-genogroup-ii-norovirus-episodes-in-young-children-2\/","title":{"rendered":"Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children"},"content":{"rendered":"<p><span style=\"color: #333399;font-size: 18pt\">Authors<\/span><\/p>\n<p><strong>Becker-Dreps S<\/strong>, Brewer-Jensen PD, Gonz\u00e1lez F, Reyes Y, Mallory ML, Guti\u00e9rrez L, <strong>Vielot NA<\/strong>, Diez-Valcarce M, Vinj\u00e9 J, Baric RS, Lindesmith LC, Bucardo F.<\/p>\n<p><span style=\"color: #333399;font-size: 18pt\">Abstract<\/span><\/p>\n<p>A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection.<\/p>\n<p><span style=\"color: #333399;font-size: 18pt\">Citation<\/span><\/p>\n<p>Becker-Dreps S, Brewer-Jensen PD, Gonz\u00e1lez F, Reyes Y, Mallory ML, Guti\u00e9rrez L, Vielot NA, Diez-Valcarce M, Vinj\u00e9 J, Baric RS, Lindesmith LC, Bucardo F. Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children. J Pediatric Infect Dis Soc. 2022 Oct 25;11(10):459-462. doi: 10.1093\/jpids\/piac063. PMID: 35849117; PMCID: PMC9595053.<\/p>\n<p><span style=\"color: #333399;font-size: 18pt\">Publication Link<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9595053\/\"><span style=\"font-size: 14pt\">Full Text<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors Becker-Dreps S, Brewer-Jensen PD, Gonz\u00e1lez F, Reyes Y, Mallory ML, Guti\u00e9rrez L, Vielot NA, Diez-Valcarce M, Vinj\u00e9 J, Baric RS, Lindesmith LC, Bucardo F. Abstract A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a &hellip; <a href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/preexisting-heterotypic-ligand-blocking-antibody-does-not-protect-against-genogroup-ii-norovirus-episodes-in-young-children-2\/\" aria-label=\"Read more about Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children\">Read more<\/a><\/p>\n","protected":false},"author":63861,"featured_media":0,"parent":413,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"class_list":["post-17105","page","type-page","status-publish","hentry","category-news","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children - Department of Family Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/preexisting-heterotypic-ligand-blocking-antibody-does-not-protect-against-genogroup-ii-norovirus-episodes-in-young-children-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children - Department of Family Medicine\" \/>\n<meta property=\"og:description\" content=\"Authors Becker-Dreps S, Brewer-Jensen PD, Gonz\u00e1lez F, Reyes Y, Mallory ML, Guti\u00e9rrez L, Vielot NA, Diez-Valcarce M, Vinj\u00e9 J, Baric RS, Lindesmith LC, Bucardo F. Abstract A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. 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