{"id":17240,"date":"2022-12-15T13:52:07","date_gmt":"2022-12-15T18:52:07","guid":{"rendered":"https:\/\/www.med.unc.edu\/fammed\/?page_id=17240"},"modified":"2022-12-15T13:52:07","modified_gmt":"2022-12-15T18:52:07","slug":"timing-and-genotype-distribution-of-symptomatic-and-asymptomatic-sapovirus-infections-and-re-infections-in-a-nicaraguan-birth-cohort","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/timing-and-genotype-distribution-of-symptomatic-and-asymptomatic-sapovirus-infections-and-re-infections-in-a-nicaraguan-birth-cohort\/","title":{"rendered":"Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort"},"content":{"rendered":"<p><span style=\"color: #333399;font-size: 18pt\">Authors<\/span><\/p>\n<p>Gonz\u00e1lez F, Diez-Valcarce M, Reyes Y, <strong>Vielot NA<\/strong>, Toval C, Guti\u00e9rrez L, Zepeda O, Cuadra EC, Bland\u00f3n P, Browne H, Bowman NM, V\u00edchez S, Vinj\u00e9 J, <strong>Becker-Dreps S<\/strong>, Bucardo F.<\/p>\n<p><span style=\"color: #333399;font-size: 18pt\">Abstract<\/span><\/p>\n<p><strong class=\"sub-title\">Objectives:\u00a0<\/strong>To characterize the timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort. <strong class=\"sub-title\">Methods:\u00a0<\/strong>Infants (n = 444) were enrolled at 10-14 days of life and followed weekly until 2 years of age. Stool were collected for each acute gastroenteritis (AGE) episode and routine stool were collected monthly. Stools were tested for sapovirus by RT-qPCR and positive samples were genotyped. <strong class=\"sub-title\">Results:\u00a0<\/strong>A total of 348 children completes 2 years of AGE weekly surveillance, 93 (26.7%) of them experienced sapovirus AGE. Most infections occurred after 5 months of age and mainly the second year of life (62.4%, 58\/93) and early in the rainy season. Sapovirus screening in all stools from a subset of 67 children, that consistently provided samples, show sapovirus infections in 27.6% (91\/330) of the AGE episode and in 2.9% (39\/1350) of the routine stool. In this subset, the median age at the first sapovirus AGE was 11.2 month (95%CI; 9.3 &#8211; 15.9), 57% (38\/67) experienced re-infections, 19 symptomatic and 19 asymptomatic; on average, sapovirus re-infections were reported 7.2 months after symptomatic and 5.3 after asymptomatic infections. Genogroups GI (64%, 69\/108) was the most common detected. Sapovirus GI.1 was more frequently detected in AGE than in routine stools (47.2%, 43\/91 vs 25.6%, 10\/39; p = 0.005) and re-infection with the same genotype was uncommon. <strong class=\"sub-title\">Conclusion:\u00a0<\/strong>The first sapovirus infections occurred around 11 months of age, whereas the median time to symptomatic re-infection was 7.2 months. Re-infections with the same sapovirus genotype were rare during 2 years of life suggesting genotype-specific protection following natural infection.<\/p>\n<p><span style=\"color: #333399;font-size: 18pt\">Citation<\/span><\/p>\n<p>Gonz\u00e1lez F, Diez-Valcarce M, Reyes Y, Vielot NA, Toval C, Guti\u00e9rrez L, Zepeda O, Cuadra EC, Bland\u00f3n P, Browne H, Bowman NM, V\u00edchez S, Vinj\u00e9 J, Becker-Dreps S, Bucardo F. Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort. Clin Microbiol Infect. 2022 Nov 21:S1198-743X(22)00585-7. doi: 10.1016\/j.cmi.2022.11.013. Epub ahead of print. PMID: 36423864.<\/p>\n<p><span style=\"color: #333399;font-size: 18pt\">Publication Link<\/span><\/p>\n<p><a href=\"https:\/\/www.clinicalmicrobiologyandinfection.com\/article\/S1198-743X(22)00585-7\/fulltext\"><span style=\"font-size: 14pt\">Full Text<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors Gonz\u00e1lez F, Diez-Valcarce M, Reyes Y, Vielot NA, Toval C, Guti\u00e9rrez L, Zepeda O, Cuadra EC, Bland\u00f3n P, Browne H, Bowman NM, V\u00edchez S, Vinj\u00e9 J, Becker-Dreps S, Bucardo F. Abstract Objectives:\u00a0To characterize the timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort. Methods:\u00a0Infants (n = &hellip; <a href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/timing-and-genotype-distribution-of-symptomatic-and-asymptomatic-sapovirus-infections-and-re-infections-in-a-nicaraguan-birth-cohort\/\" aria-label=\"Read more about Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort\">Read more<\/a><\/p>\n","protected":false},"author":63861,"featured_media":0,"parent":413,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"class_list":["post-17240","page","type-page","status-publish","hentry","category-news","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort - Department of Family Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/fammed\/research\/publications-2\/timing-and-genotype-distribution-of-symptomatic-and-asymptomatic-sapovirus-infections-and-re-infections-in-a-nicaraguan-birth-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort - Department of Family Medicine\" \/>\n<meta property=\"og:description\" content=\"Authors Gonz\u00e1lez F, Diez-Valcarce M, Reyes Y, Vielot NA, Toval C, Guti\u00e9rrez L, Zepeda O, Cuadra EC, Bland\u00f3n P, Browne H, Bowman NM, V\u00edchez S, Vinj\u00e9 J, Becker-Dreps S, Bucardo F. 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