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Dr. Gianmarco Pinton

RSS Dr. Gianmarco Pinton PubMed Publications

  • A Miniaturized Multidirectional Stacking Ultrasound Transducer for Endo-bronchoscopy Lung Nodule Ablation
    Lung cancer is the leading cause of cancer death worldwide with estimated over 230,000 being diagnosed in USA annually. Due to the poor 5-year survival rate (18.6%) for lung cancer, it is vital for the early-stage lung cancer diagnosis and therapy with curative intervention, which can dramatically reduce the mortality. Ultrasound ablation has been reported […]
    Huaiyu Wu
  • Current clinical investigations of focused ultrasound blood-brain barrier disruption: A review
    The blood-brain barrier (BBB) presents a formidable challenge in delivering therapeutic agents to the central nervous system. Ultrasound-mediated BBB disruption has emerged as a promising non-invasive technique to enhance drug delivery to the brain. This manuscript reviews fundamental principles of ultrasound-based techniques and their mechanisms of action in temporarily permeabilizing the BBB. Clinical trials employing […]
    Phillip G Durham
  • Activation of primate frontal eye fields with a CMUT phased array system
    CONCLUSIONS: In conclusion, we provide a new approach for non-invasive stimulation during performance of a behavioral task. With the ability to steer stimulation patterns and target using a large amount of transducers, the ability to provide non-invasive stimulation will be greatly improved for future clinical and research applications.
    Mitchell R Riley
  • Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models
    Computational models of acoustic wave propagation are frequently used in transcranial ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate phase delays to correct for skull distortions. To allow intercomparison between the different modeling tools and techniques used by the community, an international working group was convened to formulate a set […]
    Jean-Francois Aubry
  • Transcranial Neuromodulation Array With Imaging Aperture for Simultaneous Multifocus Stimulation in Nonhuman Primates
    Even simple behaviors arise from the simultaneous activation of multiple regions in the brain. Thus, the ability to simultaneously stimulate multiple regions within a brain circuit should allow for better modulation of function. However, performing simultaneous multifocus ultrasound neuromodulation introduces challenges to transducer design. Using 3-D Fullwave simulations, we have designed an ultrasound neuromodulation array […]
    Rebecca M Jones
  • On the Relationship between Spatial Coherence and In Situ Pressure for Abdominal Imaging
    Tissue harmonic signal quality has been shown to improve with elevated acoustic pressure. The peak rarefaction pressure (PRP) for a given transmit, however, is limited by the Food and Drug Administration guidelines for mechanical index. We have previously demonstrated that the mechanical index overestimates in situ PRP for tightly focused beams in vivo, due primarily […]
    Bofeng Zhang
  • Quantifying the Effect of Abdominal Body Wall on In Situ Peak Rarefaction Pressure During Diagnostic Ultrasound Imaging
    In this study, 3-D non-linear ultrasound simulations and experimental measurements were used to estimate the range of in situ pressures that can occur during transcutaneous abdominal imaging and to identify the sources of error when estimating in situ peak rarefaction pressures (PRPs) using linear derating, as specified by the mechanical index (MI) guideline. Using simulations, […]
    Bofeng Zhang
  • Rapid quantitative imaging of high intensity ultrasonic pressure fields
    High intensity focused ultrasound (FUS) is a noninvasive technique for treatment of tissues that can lie deep within the body. There is a need for methods to rapidly and quantitatively map FUS pressure beams for quality assurance and accelerate development of FUS systems and techniques. However, conventional ultrasound pressure beam mapping instruments, including hydrophones and […]
    Huiwen Luo
  • Super-Resolution Imaging Through the Human Skull
    High-resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and have high variability across individuals. Here, we demonstrate the feasibility of human transcranial super-resolution imaging using a geometrical focusing approach to efficiently concentrate energy […]
    Danai E Soulioti
  • Adaptive Multifocus Beamforming for Contrast-Enhanced-Super-Resolution Ultrasound Imaging in Deep Tissue
    Contrast-enhanced-super-resolution ultrasound imaging, also referred to as ultrasound localization microscopy, can resolve vessels that are smaller than the diffraction limit and has recently been able to generate super-resolved vascular images of shallow in vivo structures in small animals. To fully translate this technology to the clinic, it is advantageous to be able to detect microbubbles […]
    David Espindola