Dr. Vibhor Krishna

Dr. Vibhor Krishna PubMed Publications

• Unilateral magnetic resonance-guided focused ultrasound for medication-refractory essential tremor: 5-year continued access study
  CONCLUSION: MRgFUS thalamotomy is a safe and effective long-term treatment for patients with medication-refractory ET and is associated with improved QoL.
  Pejman Ghanouni
• Cognitive Effects of MR-Guided Focused Ultrasound Thalamotomy-Time to Evaluation-Reply
  No abstract
  Michael G Kaplitt
• The Use of Focused Ultrasound Ablation for Movement Disorders
  Focused ultrasound ablation achieves selective thermal lesioning of the thalamic and basal ganglia targets using real-time MR imaging guidance. It is US Food and Drug Administration-approved to treat essential tremor and Parkinson's disease tremor, fluctuations, and dyskinesias. Patients often seek focused ultrasound treatment because symptom relief is immediate, and hardware implantation is not required. This […]
  Nicole Silva
• Brain targeting for focused ultrasound essential tremor ablation: proceedings from the 2023 Focused Ultrasound Foundation workshop
  Essential tremor (ET) is the most common movement disorder globally and has negative impacts on quality of life. While medical treatments exist, approximately 50% of patients have tremor that is refractory to medication or experience intolerable medication side effects. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an option for these patients and while incisionless, it […]
  Melissa M J Chua
• Introduction. Focused ultrasound: current and future indications
  No abstract
  Rees Cosgrove
• Probabilistic Refinement of Focused Ultrasound Thalamotomy Targeting for Parkinson's Disease Tremor
  CONCLUSION: We demonstrated that the most effective MRgFUS thalamotomy target in TDPD is in the ventral intermediate nucleus/ventralis oralis posterior border region. This finding offers new insights into the thalamic regions instrumental in tremor control, with pivotal implications for improving treatment outcomes. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf […]
  Cletus Cheyuo
• Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor: An Open-Label Clinical Trial
  CONCLUSIONS AND RELEVANCE: Staged, bilateral focused ultrasound thalamotomy significantly reduced tremor severity and functional disability scores. Adverse events for speech, swallowing, and ataxia were mostly mild and transient.
  Michael G Kaplitt
• Neuromodulation: Update on current practice and future developments
  No abstract
  Vibhor Krishna
• Diffusion and functional MRI in surgical neuromodulation
  Surgical neuromodulation has witnessed significant progress in recent decades. Notably, deep brain stimulation (DBS), delivered precisely within therapeutic targets, has revolutionized the treatment of medication-refractory movement disorders and is now expanding for refractory psychiatric disorders, refractory epilepsy, and post-stroke motor recovery. In parallel, the advent of incisionless treatment with focused ultrasound ablation (FUSA) can offer […]
  Nicole A Silva
• Current clinical investigations of focused ultrasound blood-brain barrier disruption: A review
  The blood-brain barrier (BBB) presents a formidable challenge in delivering therapeutic agents to the central nervous system. Ultrasound-mediated BBB disruption has emerged as a promising non-invasive technique to enhance drug delivery to the brain. This manuscript reviews fundamental principles of ultrasound-based techniques and their mechanisms of action in temporarily permeabilizing the BBB. Clinical trials employing […]
  Phillip G Durham