Department of Genetics Publications for May 2026

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging. 

Saw WY, Kim K, Huang Y, Yun JH, Ma X, Bacon J, Pershad Y, Levy D, O’Connor GT, Boerwinkle E, Barr RG, Rich SS, Rotter JI, Carson AP, Raffield LM, Gharib SA, Bartz TM, Psaty BM, Sofer T, North KE, Kaplan R, Oelsner EC, Manichaikul A, Bick AG, Scheet P, Reiner AP; NHLBI Trans-Omics for Precision Medicine Consortium; Jakubek YA, Auer PL, Cho MH, DeMeo DL.

Am J Respir Crit Care Med. 2026 Mar 19:aamag120. doi: 10.1093/ajrccm/aamag120. Online ahead of print.

PMID: 42085243

Decoding drug-responsive cell subpopulations in triple-negative breast cancer using single-cell multiomics. 

Wang Y, Haase S, Whitman A, Beltran AS, Spanheimer PM, Brunk E.

iScience. 2026 Mar 21;29(5):115445. doi: 10.1016/j.isci.2026.115445. eCollection 2026 May 15.

PMID: 42088352      Free PMC article.

Altering the dosage of meiotic crossover-associated RING finger proteins affects crossover number and interference in Drosophila. 

Frantz E, Santa Rosa P, McMahan S, Sekelsky J.

G3 (Bethesda). 2026 May 8:jkag121. doi: 10.1093/g3journal/jkag121. Online ahead of print.

PMID: 42102323

Genetic diversity of collaborative cross mice enables the establishment of a novel Chlamydia muridarum female genital tract infection model. 

Darville T, Girardi J, Poston T, Campbell C, Sun X, Hao Y, Zhang Y, Liu C, Duncan B, Zou F, O’Connell CM, Zheng X.

Infect Immun. 2026 May 5:e0074625. doi: 10.1128/iai.00746-25. Online ahead of print.

PMID: 42084375

Improve genetic quality control to increase rigor and reproducibility of mouse research. 

Pardo-Manuel de Villena F, Amos-Landgraf JM, Bell TA, Blanchard MW, Brennan J, Carlson C, Ciavatta DJ, Cotney PA, Ferris MT, Hock P, Korf I, Lloyd KCK, Lutz C, Lynch RM, Magnuson T, Murray SA, Patel S, Reinholdt LG, Sigmon JS, Willis B, Xenakis JG.

Science. 2026 May 14;392(6799):698-700. doi: 10.1126/science.aec3177. Epub 2026 May 14.

PMID: 42133765

Genes, other than Muc5b, are associated with bleomycin-induced lung injury. 

Wang Y, Hennessy C, Dobrinskikh E, Humphries SM, Hatakka K, Ackert-Bicknell CL, Godfrey DA, Kelada SNP, Keele GR, Cardwell J, Peljto A, Clouthier DE, Yang IV, Schwartz DA.

Commun Biol. 2026 May 12. doi: 10.1038/s42003-026-10239-3. Online ahead of print.

PMID: 42120750

Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice. 

Misumi I, Shirasaki T, Xie L, Yonish B, González-López O, Hirai-Yuki A, Chen X, Li Y, Whitmire JK, Lemon SM.

PLoS Pathog. 2026 May 11;22(5):e1014213. doi: 10.1371/journal.ppat.1014213. eCollection 2026 May.

PMID: 42113844      Free PMC article.

Multi-omics integration predicts the incidence of 17 diseases in the UK Biobank. 

Du J, Zhou M, Wang H, Wang J, Raffield LM, Zhou R, Li Y, Chen C, Sun Q.

Nat Commun. 2026 May 9. doi: 10.1038/s41467-026-73017-z. Online ahead of print.

PMID: 42106324

A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive-Compulsive Symptoms in Psychiatric Genetic Studies: A Cross-Continental Study Within the Ancestral Population Network. 

Diaz-Zuluaga AM, Anderberg JL, Ramirez-Diaz AM, Marques AH, Rast CE, Bustamante D, Jonker D, Valencia-Echeverry J, Kyebuzibwa J, Muñoz JS, van der Walt K, Ramirez MC, Wootton O, Frederick RM, Stroud RE 2nd, Gur R, Rhee SJ, Jha SC, Gichuru S, Service S, Reus VI, Dickens A, Lopez-Jaramillo C, Bearden CE, Stein DJ, Susser ES, Crowley JJ, Flint J, Kendler KS, Atwoli L, Pato MT, Freimer NB, Ophoff RA, Ahn YM, Olde Loohuis L, Storch EA, Gelaye B.

Am J Med Genet B Neuropsychiatr Genet. 2026 May 11. doi: 10.1002/ajmg.b.70019. Online ahead of print.

PMID: 42109083      Review.

Blinded by the smoke: Are we ignoring a key modifier of response in NMIBC trials? 

Kay H, Kim WY, Matulewicz RS, Damrauer JS, Bjurlin MA.

J Urol. 2026 May 12:101097JU0000000000005122. doi: 10.1097/JU.0000000000005122. Online ahead of print.

PMID: 42119042

Streptomyces enrichment in roots during drought is uncoupled from plant benefit and is driven by host suppression of iron uptake and immunity. 

Fitzpatrick CR, Allen Smith R, Hige J, Law TF, Russ D, Ajayi OE, Eida AA, Jacob P, Jowers M, Kumar N, Lai CTU, Anguita-Maeso M, Peterson SB, Saha C, Skelly T, Zhao Q, Zhou W, Grant SR, Mougous JD, Jones CD, Dangl JL.

Cell. 2026 May 28;189(11):3306-3323.e15. doi: 10.1016/j.cell.2026.04.027. Epub 2026 May 8.

PMID: 42105760

Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk. 

Barnao KM, Hubbard AK, Chan ICC, Zhou W, Jakubek YA, Genovese G, Wong WSW, Kelly RL, Young CD, Brown DW, Huang WY, Freedman ND, Jones K, Hutchinson A, Hicks B, Tran D, Arnett D, Barnes KC, Bis JC, Boerwinkle E, Brody JA, Carson AP, Chasman DI, Cho MH, Desai P, Doyle MF, Fornage M, Guo X, Heard-Costa N, Irvin MR, Johnson AD, Kardia SLR, Kooperberg C, Levy D, Lewis JP, Li Y, Loos RJF, Mack TM, Mathias RA, Mitchell BD, North KE, Pankratz N, Peyser PA, Preuss MH, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Silverman EK, Smith AV, Smith JA, Stilp A, Cao Y, Scheet P, Reiner AP, Bick AG, Chanock SJ, Auer PL, Bolton KL, Machiela MJ.

Nat Commun. 2026 May 21. doi: 10.1038/s41467-026-73302-x. Online ahead of print.

PMID: 42168198

Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body. 

Fan Z, Yang Y, Guo Y, Li Y, Shu J, Yang X, Li B, Lin J, Wang Q, Paschou P, Li T, Gehrman P, Zhu H, Zhao B.

Commun Med (Lond). 2026 May 20. doi: 10.1038/s43856-026-01656-w. Online ahead of print.

PMID: 42162304

An Efficient Lasso Framework for Admixture-Aware Polygenic Scores. 

Ockerman F, Chen BD, Sun Q, Kharitonova EV, Chen C, Zhou LY, Loos RJF, Kooperberg C, Peters U, Haessler J, Reiner AP, Jung SY, Manson JE, Nassir R, North KE, Buyske S, Haiman CA, Conti DV, Wilkens LR, Lange EM, Cox NJ, Cao H, Raffield LM, Li Y, Tao R.

HGG Adv. 2026 May 18:100628. doi: 10.1016/j.xhgg.2026.100628. Online ahead of print.

PMID: 42157490

Tissue transcriptional programs stratify Crohn’s disease by therapeutic response and clinical outcomes. 

Awad A, Huan B, Shanahan MT, Weaver D, Silverstein S, Lau G, Lian G, Furey B, McMichael BD, Arias A, Keith BP, Shumway AJ, Sethupathy P, Furey TS, Sheikh SZ.

Sci Rep. 2026 May 19. doi: 10.1038/s41598-026-53070-w. Online ahead of print.

PMID: 42156958

Genome-wide mutation spectra of canonical and atypical UV photoproducts in S. cerevisiae. 

Laughery MF, Haueter JC, Patchett HN, Mieczkowski PA, Roberts SA, Wyrick JJ.

Nucleic Acids Res. 2026 May 20;54(10):gkag482. doi: 10.1093/nar/gkag482.

PMID: 42165128      Free PMC article.

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types. 

Sauty SM, Shine J, Bostan H, Li JL, Mieczkowski PA, Loeser RF, Diekman BO, Gordenin DA.

PLoS Genet. 2026 May 20;22(5):e1012156. doi: 10.1371/journal.pgen.1012156. eCollection 2026 May.

PMID: 42160391      Free PMC article.

Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia. 

Karnay A, Linares-Saldana R, Wang Q, Gardner Z, Liang JA, Santini GT, Haridhasapavalan KK, Nguyen SC, Hugelier S, Shewale B, Kanemaki MT, Napierala JS, Napierala M, Wilson RB, Dubois N, Poleshko A, Kim W, Shah PP, Lakadamyali M, Joyce EF, Jain R.

Mol Cell. 2026 May 21;86(10):1911-1930.e11. doi: 10.1016/j.molcel.2026.04.019. Epub 2026 May 12.

PMID: 42127908

Cytokinin histidine kinase receptors regulate multiple aspects of rice growth and development. 

Shouse EM, Aragón-Raygoza A, Tallerday EJ, Healy T, Zhou W, Boeshore SL, Burr C, Jones C, Schaller GE, Strable J, Kieber JJ.

Plant Physiol. 2026 May 22:kiag215. doi: 10.1093/plphys/kiag215. Online ahead of print.

PMID: 42172676

Long-term spatiotemporal evolution of drug-resistant Mycobacterium tuberculosis in China. 

Chen Y, Liang J, Liu D, Xu P, Jiang Q, Yang T, Liu Q, Takiff HE, Gagneux S, Gao Q.

Nat Commun. 2026 May 27. doi: 10.1038/s41467-026-73577-0. Online ahead of print.

PMID: 42204170

CNS1-dependent regulatory T cells shape recovery from acute lung injury. 

McCullough MJ, Tune MK, Griffith JW, Banten BL, He M, Feng Y, Vincent BG, Milner JJ, Tsagaratou A, Wan YY, Dang H, Doerschuk CM, Mock JR.

J Immunol. 2026 May 14;215(5):vkag119. doi: 10.1093/jimmun/vkag119.

PMID: 42201839

Optimizing strain selection for association studies under hard cost constraints. 

Rau CD, Bradley PH.

Genetics. 2026 May 27:iyag137. doi: 10.1093/genetics/iyag137. Online ahead of print.

PMID: 42199004

Reference-guided genome assembly of long non-coding rna transcripts reveals target genes associated with Crohn’s disease. 

Kennedy Ng MM, Silverstein S, Nishiyama NC, Beasley C, Lian G, Huan B, Lau G, Weaver D, Awad A, Schaner MR, Sheikh SZ, Furey TS.

Sci Rep. 2026 May 25. doi: 10.1038/s41598-026-54788-3. Online ahead of print.

PMID: 42185506

Urolithin A attenuates inflammation and enhances barrier integrity in an experimental NEC-in-a-Dish model. 

Sami AS, Mozes G, Jania CM, Maldonado-Rosado E, Hepperla AJ, Ghetie N, Puri V, Bolzan L, Yamaguchi Y, Frazer LC, Mackay S, Jala V, Akopyants NS, Good M.

Pediatr Res. 2026 May 27. doi: 10.1038/s41390-026-05124-y. Online ahead of print.

PMID: 42204364

Variant classification for mucopolysaccharidosis type I; ACMG/AMP specification for IDUA from the ClinGen lysosomal diseases variant curation expert panel. 

Lacaria M, Goldstein JL, Aschoff C, Brown K, Deshpande D, Chen-Deutsch X, Ellinwood M, Farman MR, Mendez R, Louis IV, Prout J, Roark K, Selvanathan A, Stafford A, Fernandez R, Ratzsch AC, Weaver M, Bali D, Donti T, Lund T, Pollard L, Vairo FPE, Wood T, Rehder C, Clarke L.

Mol Genet Metab. 2026 May 20;148(3):110156. doi: 10.1016/j.ymgme.2026.110156. Online ahead of print.

PMID: 42190545

Artificial Intelligence in Image-Based Cardiovascular Disease Analysis. 

Wang X, Hu M, Tsao CW, Zhu H.

Annu Rev Biomed Data Sci. 2026 May 28. doi: 10.1146/annurev-biodatasci-092624-111837. Online ahead of print.

PMID: 42207939      Review.

Pan-cancer spatial atlas of tertiary lymphoid structures. 

Cho KS, Liu Y, Pei G, Chen J, Dai Y, Liu Y, Zhou T, Bougouin A, Serrano A, Wani K, Jadhav A, Min J, Hernandez S, Lu W, Zhang D, Jiang J, Shamsutdinova D, Dai E, Peng F, Sinjab A, Guerrero PA, Julio ICL, Yu K, Clark H, Maru D, Li M, Futreal A, Lee S, Solis Soto LM, Shang L, Msaouel P, Ajani JA, Beird H, Jazaeri AA, Lazar AJ, Sautes-Fridman C, Fridman WH, Maitra A, Kadara H, Gao J, Sharma P, Wang L.

Science. 2026 May 28;392(6801):eadz2742. doi: 10.1126/science.adz2742. Epub 2026 May 28.

PMID: 42207882

USP7 inhibition perturbs proteostasis and tumorigenesis in triple-negative breast cancer. 

Kim A, Gopalakrishnan P, Suárez-Pizarro M, Chen CC, Wang X, McCoy SM, Umesh N, Mordant A, Barker NK, Herring LE, Kakati RT, Spanheimer PM, Emanuele MJ, Benavente CA.

NPJ Breast Cancer. 2026 May 23. doi: 10.1038/s41523-026-00974-5. Online ahead of print.

PMID: 42177192