Keywords: Genetics/Development/Chromatin remodeling/Gametogenesis/Meiosis
Gametogenesis is a process in which germ cells undergo meiosis to give rise to haploid sperm and egg. Understanding the mechanisms that underlie gametogenesis has profound clinical implications with respect to fertility. I am interested in studying the role of chromatin regulation in gamete development. Our current research is focused on determining the functions of the SWI/SNF family of chromatin remodelers during mouse spermatogenesis. By adopting a combination of genetic, genomic and proteomic techniques we have shown that the mammalian SWI/SNF complex coordinates germline transcription to ensure spermatogonial stem cell pluripotency and promote meiotic progression. Our studies indicate that distinct SWI/SNF subcomplexes, namely, BAF (Brm/Brg1 Associated Factor) and PBAF (Polybromo-BAF) regulate spermatogenesis in a cell type specific manner. We have discovered novel associations between BAF/PBAF complexes and germ cell specific proteins and are currently investigating the physiological relevance of these interactions.
- Menon, D.U. and Magnuson, T. (2020). Mammalian SWI/SNF chromatin remodeler essential for reductional meiosis in males. bioRxiv (Preprint) doi: https://doi.org/10.1101/2020.04.28.066647
- Menon, D.U., Shibata, Y., Mu, W., and Magnuson, T. (2019). Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germ line transcription in the mouse. Development 146: dev.174094. doi:10.1242/dev.174094
- Serber, D.W., Runge, J.S., Menon, D.U., and Magnuson, T. (2016). The mouse INO80 chromatin remodeling complex is an essential meiotic factor for spermatogenesis. Biology of Reproduction. 94 (1) 8, 1-9.
Debashish U. Menon in UNC Genetics News
June 4, 2021
Department of Genetics Welcomes New Faculty
Four new Assistant Professors have recently been appointed in the Department of Genetics.
May 6, 2019
Department of Genetics Publications from April 21-May 4, 2019
Department of Genetics faculty, postdocs, students and collaborators published fourteen papers during April 21-May 4, 2019.