Keywords: Hematopoietic stem cell self-renewal, aging and transformation; transcriptional and epigenetic regulation of hematopoietic aging; stress-induced hematopoiesis; aging-associated hematopoietic and Immune system dysfunction
As we age, our body’s ability to make new blood cells to maintain homeostasis deteriorates. This age-dependent decline in hematopoietic system function has serious consequences as it leads to bone marrow failure and compromised adaptive immune function at advanced age, which directly and indirectly contributes to many aging-associate diseases and conditions including cancer, poor response to vaccination and increased susceptibility to serious infections. Recent studies suggest that hematopoietic aging is mainly controlled by epigenetic mechanisms and therefore potentially amenable to therapeutic interventions. Our lab uses genetically engineered mouse models and next generation DNA/RNA sequencing technology to systematically study and compare age-related changes in gene expression, chromatin organization and cellular function in multiple hematopoietic cell types, in particular hematopoietic stem cells and progenitors essential for lymphoid and myeloid differentiation. Our goal is to identify cell-type-specific and common epigenetic mechanisms that causally contribute to hematopoietic aging, in order to develop new therapeutic approaches to prevent or treat aging-associated hematopoietic diseases and immune dysfunction.
- Bias 101
- LCCC DEI Townhall Impact vs. Intention. The Importance of Collaboration When Dismantling Structural Racism
- REI Groundwater Training
Shenghui He in UNC Genetics News
March 8, 2021
Department of Genetics Publications for February 21 – March 6, 2021
Department of Genetics faculty, postdocs, students and collaborators published twelve papers during February 21 – March 6, 2021.
September 8, 2020
Department of Genetics Publications for August 23 – Sept. 5, 2020
Department of Genetics faculty, postdocs, students and collaborators published eight papers during August 23 – Sept. 5, 2020.
August 10, 2020
Department of Genetics Publications for July 26 – August 8, 2020
Department of Genetics faculty, postdocs, students and staff published nine papers during July 26 – August 8, 2020.
August 13, 2018
Department of Genetics Publications for July 29 – Aug. 11, 2018
Department of Genetics faculty, postdocs, students and collaborators published eleven papers during July 29 – Aug. 11, 2018.