1.0Department of Geneticshttps://www.med.unc.edu/geneticsBetsy Clarkehttps://www.med.unc.edu/genetics/author/bclarke/Karl Shpargel, PhD | Department of Geneticsrich600338<blockquote class="wp-embedded-content" data-secret="n2E0ulNjVi"><a href="https://www.med.unc.edu/genetics/directory/karl-shpargel/">Karl Shpargel, PhD</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.med.unc.edu/genetics/directory/karl-shpargel/embed/#?secret=n2E0ulNjVi" width="600" height="338" title="“Karl Shpargel, PhD” — Department of Genetics" data-secret="n2E0ulNjVi" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript">
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https://www.med.unc.edu/genetics/wp-content/uploads/sites/481/2016/10/Karl-Shpargel.jpg18562448Research Interests Keywords: chromatin, epigenetics, histone, craniofacial, cancer The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is … Read more