{"id":2853,"date":"2016-10-24T19:18:03","date_gmt":"2016-10-24T23:18:03","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/directory\/frank-conlon\/"},"modified":"2025-04-24T14:50:25","modified_gmt":"2025-04-24T18:50:25","slug":"frank-conlon","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/genetics\/directory\/frank-conlon\/","title":{"rendered":"Frank Conlon, PhD"},"content":{"rendered":"<p><!-- description --><\/p>\n<h2>Research Interests<\/h2>\n<p><strong class=\"keywords\">Keywords: Developmental genetics<\/strong><\/p>\n<p><strong><a href=\"http:\/\/www.conlon-lab.com\/\">Lab Website<\/a><\/strong><\/p>\n<p>Human congenital heart disease, the most common form of heart disease in childhood, occurs in about 1% of live births and up to 10% of stillbirths. Presently, the most effective therapy for cardiac diseases is heart transplantation. However, due to the shortage of organs, cost and inaccessibility of treatment for most affected individuals this remains a limited therapeutic option. Alternative treatment is the administration of drugs that improve myocardial contractility, though this treatment is only effective as a short term therapy, with the 5-year survival rate using current agents being less than 60%. An alternative therapeutic option is to treat patients with cardiac progenitor cell populations that could infiltrate and repair damaged heart tissue. Thus, the ability to isolate and propagate cell populations that can differentiate into cardiomyocytes in vivo offers the opportunity to treat a wide range of cardiac diseases. To this end, our lab is interested in understanding the relationship between cardiac progenitor proliferation and the onset of cardiac differentiation focusing on the endogenous roles of the transcription factors TBX5 and CST and the protein phosphatase SHP-2.<\/p>\n<h2>Frank Conlon in UNC Genetics News<\/h2>\n            <div class=\"wc-cards\"><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/rachel-szymanski-gmb-graduate-student-frank-conlon-lab-has-received-a-prestigious-american-heart-association-fellowship\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2025\/12\/GMB-headshot-600x600.png\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Rachel Syzmanski\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2025\/12\/GMB-headshot-600x600.png 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2025\/12\/GMB-headshot-150x150.png 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">December 11, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Rachel Szymanski, GMB Graduate Student (Frank Conlon Lab), has received a Prestigious American Heart Association Fellowship<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Rachel Szymanski, a PhD in the Conlon Lab, has received a prestigious American Heart Association fellowship to investigate the role of the CRL4 ubiquitin-ligase complex in embryonic heart development.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Rachel Szymanski, GMB Graduate Student (Frank Conlon Lab), has received a Prestigious American Heart Association Fellowship\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-august-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">September 14, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for August 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 25 papers in August 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for August 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-june-29th-august-2nd-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">August 8, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for June 29th &#8211; August 2nd, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 39 papers during June 29th - August 2nd 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for June 29th &#8211; August 2nd, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-march-30th-april-26th-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">May 9, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for March 30th &#8211; April 26th, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 25 papers during March 30th - April 26th 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for March 30th &#8211; April 26th, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/microrna-responsible-for-sex-differences-in-cardiac-physiology-disease\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"188\" height=\"250\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Frank-Conlon.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Frank Conlon\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">February 6, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">MicroRNA Responsible for Sex Differences in Cardiac Physiology, Disease<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Researchers in the laboratories of Frank L. Conlon, PhD, Professor of Biology and Genetics, and Bill Marzluff, PhD, Kenan Distinguished Professor of Biochemistry and Biophysics, have pinpointed small molecules that greatly affect differences in heart health in men and women. These results uncover one of the molecular reasons behind sex disparities in heart disease.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about MicroRNA Responsible for Sex Differences in Cardiac Physiology, Disease\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-january-5th-18th-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">January 20, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for January 5th &#8211; 18th, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 18 papers during January 5th - 18th, 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for January 5th &#8211; 18th, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-april-14th-27th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">April 29, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for April 14th &#8211; 27th, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 12 papers during April 14th - 27th 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for April 14th &#8211; 27th, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-december-17th-2023-january-6th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">January 8, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for December 17th 2023 &#8211; January 6th 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 12 papers during December 17th 2023 - January 6th 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for December 17th 2023 &#8211; January 6th 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/unc-bcb-and-gmb-graduate-students-baran-flores-mcafee-and-szymanski-volunteer-as-unc-ambassadors-in-the-shadow-a-scientist-program\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/12\/Baran-Flores-McAfee-Szymanski-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Baran Flores McAfee Szymanski\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/12\/Baran-Flores-McAfee-Szymanski-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/12\/Baran-Flores-McAfee-Szymanski-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">December 11, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">UNC BCB and GMB Graduate Students Baran, Flores, McAfee, and Szymanski Volunteer as UNC Ambassadors in the Shadow a Scientist program<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">On November 29, UNC graduate students Kerstin Baran, JP Flores, Jessica McAfee, and Rachel Szymanski, volunteered their time and expertise for a Shadow a Scientist outreach event held on the UNC Chapel Hill campus.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about UNC BCB and GMB Graduate Students Baran, Flores, McAfee, and Szymanski Volunteer as UNC Ambassadors in the Shadow a Scientist program\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-september-24th-october-7th-2023\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 9, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for September 24th &#8211; October 7th, 2023<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 12 papers during September 24th - October 7th 2023.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for September 24th &#8211; October 7th, 2023\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article>            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Keywords: Developmental genetics Lab Website Human congenital heart disease, the most common form of heart disease in childhood, occurs in about 1% of live births and up to 10% of stillbirths. Presently, the most effective therapy for cardiac diseases is heart transplantation. However, due to the shortage of organs, cost and inaccessibility of &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-september-24th-october-7th-2023\/\" aria-label=\"Read more about Department of Genetics Publications for September 24th &#8211; October 7th, 2023\">Read more<\/a><\/p>\n","protected":false},"featured_media":12930,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-2853","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Frank Conlon, PhD | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/frank-conlon\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Frank Conlon, PhD | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Research Interests Keywords: Developmental genetics Lab Website Human congenital heart disease, the most common form of heart disease in childhood, occurs in about 1% of live births and up to 10% of stillbirths. 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