{"id":2958,"date":"2016-10-24T19:17:31","date_gmt":"2016-10-24T23:17:31","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/directory\/samir-kelada-phd-mph\/"},"modified":"2025-11-20T12:14:52","modified_gmt":"2025-11-20T17:14:52","slug":"samir-kelada-phd-mph","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/genetics\/directory\/samir-kelada-phd-mph\/","title":{"rendered":"Samir Kelada, PhD, MPH"},"content":{"rendered":"<p><!-- description --><\/p>\n<h2>Research Interests<\/h2>\n<p><strong class=\"keywords\">Key words: gene-environment interactions, systems genetics, asthma, environmentally-induced lung disease<\/strong><\/p>\n<p>My long-standing research interest has been in gene-environment interactions (GxE) with environmental health hazards. My motivation stems from the desire to understand inter-individual variation in response to exposures associated with disease, and my training in both toxicology and genetics allows me to marry these two disciplines. The central focus of my lab is on the identification of GxE with air pollutants and allergens that affect the development of common airway diseases like asthma and COPD, with the mindset that identifying GxE provides an important means to gain information about disease susceptibility and mechanisms underlying the association between exposures and disease.<\/p>\n<p>Robust detection of GxE requires maximizing information about both genetic variation (G) and environmental exposure (E), which is very challenging in human studies. Thus, we leverage model systems, mice in particular, in which we control both G and E. On the genetics side, we have worked heavily with the Collaborative Cross (CC), a mouse genetics reference population that features abundant genetic variation in format of inbred lines. On the exposure side, we have established state-of-the-art inhalation exposure systems to deliver precise air pollutant exposures to rodents; and we aim to expand our capacity to model exposures to additional air pollutants and other common respiratory exposures associated with respiratory disease.<\/p>\n<p>Ultimately, of course, we seek to translate our findings from model systems to humans. To that end, we collaborate with investigators at the <a href=\"https:\/\/www.med.unc.edu\/cemalb\/\">UNC Center for Environmental Medicine, Asthma and Lung Biology<\/a>, the <a href=\"https:\/\/sph.unc.edu\/cehs\/center-for-environmental-health-and-susceptibility\/\">UNC Center for Environmental Health and Susceptibility<\/a>, and the UNC <a href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/\">Marsico Lung Institute<\/a>, to enable such cross-species comparisons in the context of clinical and\/or epidemiologic data. Thus, in total, our work is multidisciplinary and utilizes approaches from genetics, toxicology, and epidemiology. To learn about current projects in the lab, please see our <a href=\"https:\/\/keladalab.web.unc.edu\/\">website<\/a>.<\/p>\n<h2>Mentor Training:<\/h2>\n<ul>\n<li>Faculty Mentoring Workshop for Biomedical Researchers<\/li>\n<\/ul>\n<h2>Training Program Affiliations:<\/h2>\n<ul>\n<li>Bioinformatics and Computational Biology<\/li>\n<li>Genetics and Molecular Biology<\/li>\n<li>Toxicology<\/li>\n<\/ul>\n<h2>Publications<\/h2>\n<ul>\n<li><strong><span class=\"largeFont\"><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?cmd=search&amp;db=pubmed&amp;term=Kelada%20SN[Author]\" rel=\"noopener noreferrer\">PubMed<\/a><\/span><\/strong><\/li>\n<\/ul>\n<h2>Samir Kelada in UNC Genetics News<\/h2>\n            <div class=\"wc-cards\"><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/kelada-promoted-to-professor\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"188\" height=\"250\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Samir-Kelada-2024.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Samir Kelada 2024\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">November 20, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Kelada Promoted to Professor<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Samir Kelada has been promoted to Full Professor with tenure in the Department of Genetics, effective November 14, 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Kelada Promoted to Professor\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/kelada-receives-new-r01-grant-from-niehs\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"188\" height=\"250\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Samir-Kelada-2024.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Samir Kelada 2024\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 2, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Kelada Receives New R01 Grant from NIEHS<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Samir Kelada (Associate Professor) was awarded a new R01 grant from NIEHS for his\u00a0project titled \u201cDiscovery of gene-by-air pollution interactions in respiratory disease using genetically diverse mice with\u00a0validation in humans\u201d.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Kelada Receives New R01 Grant from NIEHS\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-june-29th-august-2nd-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">August 8, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for June 29th &#8211; August 2nd, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 39 papers during June 29th - August 2nd 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for June 29th &#8211; August 2nd, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-june-1st-28th-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">July 1, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for June 1st &#8211; 28th, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 25 papers during June 1st - 28th 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for June 1st &#8211; 28th, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/drs-smith-and-kelada-publish-a-new-paper-in-environmental-health-perspectives\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"522\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2025\/06\/Greg-Smith-and-Samir-Kelada-600x522.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Greg Smith and Samir Kelada\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">June 5, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Drs. Smith and Kelada publish a new paper in Environmental Health Perspectives<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Greg Smith and Dr. Samir Kelada recently published a paper titled \"A new mouse model for ozone health effects research\" in Environmental Health Perspectives.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Drs. Smith and Kelada publish a new paper in Environmental Health Perspectives\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-march-30th-april-26th-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">May 9, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for March 30th &#8211; April 26th, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 25 papers during March 30th - April 26th 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for March 30th &#8211; April 26th, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/dr-yun-li-and-team-publish-new-model-endoprs-in-ajhg\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"522\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2025\/04\/Yun-Li-and-Elena-Kharitonova-600x522.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Yun Li and Elena Kharitonova\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">April 8, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Dr. Yun Li and Team Publish New Model (endoPRS) in AJHG<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Yun Li, PhD (Professor, Genetics) together with first author Elena Kharitonova (PhD Student, Biostatistics) have published a new paper in the American Journal of Human Genetics (AJHG) titled \u201cEndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints \u2013 a study in asthma\u201d.\u00a0<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Dr. Yun Li and Team Publish New Model (endoPRS) in AJHG\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/kelada-awarded-new-r01-from-niehs\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"188\" height=\"250\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Samir-Kelada-2024.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Samir Kelada 2024\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">January 10, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Kelada Awarded New R01 from NIEHS<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Samir Kelada (Associate Professor, Genetics) received a new R01 grant from the National Institute for Environmental Health Sciences (NIEHS) for his project titled \u201cGenetic mechanisms underlying maladaptive respiratory responses to air pollution\u201d.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Kelada Awarded New R01 from NIEHS\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-may-12th-june-8th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">June 10, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for May 12th &#8211; June 8th, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 23 papers during May 12th - June 8th 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for May 12th &#8211; June 8th, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/dr-samir-kelada-interviewed-at-society-of-toxicology-annual-meeting\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2024\/03\/Samir-Kelada-Interview-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Samir Kelada Interview\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2024\/03\/Samir-Kelada-Interview-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2024\/03\/Samir-Kelada-Interview-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 15, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Dr. Samir Kelada Interviewed at Society of Toxicology Annual Meeting<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Samir Kelada, PhD (Associate Professor, Genetics) was interviewed by Society of Toxicology TV during the SOT 63rd Annual Meeting in Salt Lake City.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Dr. Samir Kelada Interviewed at Society of Toxicology Annual Meeting\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article>            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Key words: gene-environment interactions, systems genetics, asthma, environmentally-induced lung disease My long-standing research interest has been in gene-environment interactions (GxE) with environmental health hazards. My motivation stems from the desire to understand inter-individual variation in response to exposures associated with disease, and my training in both toxicology and genetics allows me to marry &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/dr-samir-kelada-interviewed-at-society-of-toxicology-annual-meeting\/\" aria-label=\"Read more about Dr. Samir Kelada Interviewed at Society of Toxicology Annual Meeting\">Read more<\/a><\/p>\n","protected":false},"featured_media":14511,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-2958","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Samir Kelada, PhD, MPH | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/samir-kelada-phd-mph\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Samir Kelada, PhD, MPH | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Research Interests Key words: gene-environment interactions, systems genetics, asthma, environmentally-induced lung disease My long-standing research interest has been in gene-environment interactions (GxE) with environmental health hazards. 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