{"id":2972,"date":"2016-10-24T19:17:00","date_gmt":"2016-10-24T23:17:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/"},"modified":"2025-04-15T14:18:50","modified_gmt":"2025-04-15T18:18:50","slug":"yuliya-pylayeva-gupta-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/","title":{"rendered":"Yuliya Pylayeva-Gupta, PhD"},"content":{"rendered":"<p><!-- description --><\/p>\n<h2>Research Interests<\/h2>\n<p><strong class=\"keywords\">Key words: pancreatic cancer, oncogenic Kras, tumor immunology, tumor microenvironment<\/strong><\/p>\n<p><a href=\"https:\/\/www.pylayeva-gupta-lab.com\"><strong>Lab Website<\/strong><\/a><\/p>\n<p>While it is appreciated that host immunity plays a critical role in regulating tumorigenesis, the mechanisms behind immune response evasion in Kras-driven pancreatic cancer are poorly understood. For example, while T cells with specificities against tumor antigens have been found in human pancreatic ductal adenocarcinoma, it is not clear if antigen-dependent pathways would be utilized as the main driving forces in productive anti-tumor immunity. Meanwhile, this information is crucial for the development of T- and dendritic-cell based immunotherapies. Similarly, while systemic immune changes have been documented in patients with metastatic pancreatic cancer, our understanding of the role of the immune system in the process of pancreatic cancer metastasis is scant.<\/p>\n<p>Our current research aims to elucidate the cellular and molecular mechanisms of immune cell co-option by cancer cells, and to determine the significance of this crosstalk in tumor initiation and progression to metastatic disease. To achieve this, we use genetically engineered spontaneous and transplant-based mouse models of pancreatic cancer that feature activation of oncogenic Kras and mutations in tumor suppressor p53. These mouse models recapitulate key features of human pancreatic adenocarcinomas characterized by extensive remodeling of the surrounding microenvironment complete with pronounced influx of immune cells that shape the inflammatory and immunosuppressive pro-tumorigenic milieu. These pathological features of pancreatic ductal adenocarcinoma highlight the potential clinical significance of investigational efforts into mechanisms of immunomodulation in pancreatic cancer.<\/p>\n<h2>Mentor Training:<\/h2>\n<ul>\n<li>Faculty Mentoring Workshop for Biomedical Researchers<\/li>\n<\/ul>\n<h2>Training Program Affiliations:<\/h2>\n<ul>\n<li>Cell Biology and Physiology<\/li>\n<li>Genetics and Molecular Biology<\/li>\n<li>Microbiology and Immunology<\/li>\n<\/ul>\n<h2>Publications<\/h2>\n<p class=\" \"><strong><span class=\"largeFont\"><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=pylayeva-gupta+or+pylayeva\" rel=\"noopener noreferrer\">PubMed Link<\/a><\/span><\/strong><\/p>\n<h2>Yuliya Pylayeva-Gupta in UNC Genetics News<\/h2>\n            <div class=\"wc-cards\"><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-february-2026\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 17, 2026<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for February 2026<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 26 papers in February 2026.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for February 2026\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-december-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">February 20, 2026<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for December 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 37 papers in December 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for December 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-april-27th-may-31st-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">June 3, 2025<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for April 27th &#8211; May 31st, 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 42 papers during April 27th - May31st 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for April 27th &#8211; May 31st, 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-october-13th-26th-2024\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 28, 2024<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for October 13th &#8211; 26th, 2024<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 13 papers during October 13th - 26th, 2024.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for October 13th &#8211; 26th, 2024\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/nci-awards-earp-pylayeva-gupta-five-year-2-69-million-pancreatic-cancer-research-grant\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"366\" height=\"457\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/03\/Pylayeva-Gupta-Yuliya.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/03\/Pylayeva-Gupta-Yuliya.jpg 366w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/03\/Pylayeva-Gupta-Yuliya-240x300.jpg 240w\" sizes=\"auto, (max-width: 366px) 100vw, 366px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 28, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">NCI awards Earp, Pylayeva-Gupta five-year, $2.69 million pancreatic cancer research grant<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">The National Cancer Institute has awarded UNC Lineberger\u2019s\u00a0Shelley Earp, MD,\u00a0and\u00a0Yuliya Pylayeva-Gupta, PhD, a\u00a0five-year, $2.69 million R01 research project grant\u00a0to investigate approaches to overcome barriers to pancreatic cancer immunotherapies. Their objective is to understand resistance to modern immunotherapy and to design more effective combination therapies.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about NCI awards Earp, Pylayeva-Gupta five-year, $2.69 million pancreatic cancer research grant\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-september-25th-october-8th-2022\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 10, 2022<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for September 25th \u2013 October 8th, 2022<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 10 papers during September 25th\u00a0\u2013 October 8th, 2022.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for September 25th \u2013 October 8th, 2022\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/dr-yuliya-pylayeva-gupta-awarded-2022-hettleman-prize\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"190\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Yuliya Pylayeva-Gupta, PhD\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 5, 2022<\/p><h3 class=\"wc-card__title wc-card__title--3\">Dr. Yuliya Pylayeva-Gupta Awarded 2022 Hettleman Prize<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Yuliya Pylayeva-Gupta, PhD (Associate Professor, Genetics) has been awarded a Phillip and Ruth Hettleman Prize for Artistic and Scholarly Achievement, recognizing her groundbreaking and innovate research and future career promise.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Dr. Yuliya Pylayeva-Gupta Awarded 2022 Hettleman Prize\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-september-11th-24th-2022\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">September 26, 2022<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for September 11th \u2013 24th, 2022<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 10 papers during September 11th\u00a0- 24th, 2022.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for September 11th \u2013 24th, 2022\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-august-14th-27th-2022\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">August 29, 2022<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for August 14th \u2013 27th, 2022<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 14 papers during August 14th \u2013 27th, 2022.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for August 14th \u2013 27th, 2022\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-january-16th-29th-2022\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">January 31, 2022<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications  January 16th \u2013 29th, 2022<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 17 papers during January 16th \u2013 29th, 2022.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications  January 16th \u2013 29th, 2022\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article>            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Key words: pancreatic cancer, oncogenic Kras, tumor immunology, tumor microenvironment Lab Website While it is appreciated that host immunity plays a critical role in regulating tumorigenesis, the mechanisms behind immune response evasion in Kras-driven pancreatic cancer are poorly understood. For example, while T cells with specificities against tumor antigens have been found in &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-january-16th-29th-2022\/\" aria-label=\"Read more about Department of Genetics Publications  January 16th \u2013 29th, 2022\">Read more<\/a><\/p>\n","protected":false},"featured_media":7828,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-2972","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Yuliya Pylayeva-Gupta, PhD | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yuliya Pylayeva-Gupta, PhD | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Research Interests Key words: pancreatic cancer, oncogenic Kras, tumor immunology, tumor microenvironment Lab Website While it is appreciated that host immunity plays a critical role in regulating tumorigenesis, the mechanisms behind immune response evasion in Kras-driven pancreatic cancer are poorly understood. For example, while T cells with specificities against tumor antigens have been found in &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-15T18:18:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"190\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/\",\"name\":\"Yuliya Pylayeva-Gupta, PhD | Department of Genetics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg\",\"datePublished\":\"2016-10-24T23:17:00+00:00\",\"dateModified\":\"2025-04-15T18:18:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg\",\"width\":200,\"height\":190,\"caption\":\"Yuliya Pylayeva-Gupta, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/genetics\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Yuliya Pylayeva-Gupta, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/\",\"name\":\"UNC Department of Genetics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/genetics\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\",\"name\":\"UNC Department of Genetics\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png\",\"width\":982,\"height\":151,\"caption\":\"UNC Department of Genetics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Yuliya Pylayeva-Gupta, PhD | Department of Genetics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/","og_locale":"en_US","og_type":"article","og_title":"Yuliya Pylayeva-Gupta, PhD | Department of Genetics","og_description":"Research Interests Key words: pancreatic cancer, oncogenic Kras, tumor immunology, tumor microenvironment Lab Website While it is appreciated that host immunity plays a critical role in regulating tumorigenesis, the mechanisms behind immune response evasion in Kras-driven pancreatic cancer are poorly understood. For example, while T cells with specificities against tumor antigens have been found in &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/","og_site_name":"Department of Genetics","article_modified_time":"2025-04-15T18:18:50+00:00","og_image":[{"width":200,"height":190,"url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/","url":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/","name":"Yuliya Pylayeva-Gupta, PhD | Department of Genetics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg","datePublished":"2016-10-24T23:17:00+00:00","dateModified":"2025-04-15T18:18:50+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg","contentUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Pylayeva-Gupta-Yuliya-200x280-2-e1609774097244.jpg","width":200,"height":190,"caption":"Yuliya Pylayeva-Gupta, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/yuliya-pylayeva-gupta-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/genetics\/"},{"@type":"ListItem","position":2,"name":"Yuliya Pylayeva-Gupta, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/genetics\/#website","url":"https:\/\/www.med.unc.edu\/genetics\/","name":"UNC Department of Genetics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/genetics\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/genetics\/#organization","name":"UNC Department of Genetics","url":"https:\/\/www.med.unc.edu\/genetics\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png","contentUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png","width":982,"height":151,"caption":"UNC Department of Genetics"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/"}}]}},"_upd_display_name":["Yuliya Pylayeva-Gupta, PhD"],"_upd_reverse_display_name":["Pylayeva-Gupta, Yuliya"],"_upd_last_name":["Pylayeva-Gupta"],"_upd_first_name":["Yuliya"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Associate Professor of Genetics<\/strong>\r\nOffice: 22-046\u00a0Lineberger Comprehensive Cancer Center\r\nPhone:\u00a0919-962-8296\r\n<a class=\"email-link\" title=\"\" href=\"mailto:yuliyap1[at]email.unc.edu\" target=\"_self\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"yuliyap1@email.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-962-8296","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"22-046 Lineberger Cancer Center","address-2":"CB#7295","campus-box":"","city":"Chapel Hill","state":"NC","zip":"27599-7295"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory\/2972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory\/2972\/revisions"}],"predecessor-version":[{"id":15004,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory\/2972\/revisions\/15004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/media\/7828"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/media?parent=2972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}