{"id":3013,"date":"2016-10-24T19:19:24","date_gmt":"2016-10-24T23:19:24","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/"},"modified":"2025-04-15T14:20:38","modified_gmt":"2025-04-15T18:20:38","slug":"karl-shpargel","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/","title":{"rendered":"Karl Shpargel, PhD"},"content":{"rendered":"<h2>Research Interests<\/h2>\n<p><strong class=\":keywords\">Keywords:\u00a0<\/strong><strong>chromatin, epigenetics, histone, craniofacial, cancer<\/strong><\/p>\n<p>The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is accomplished through a variety of techniques including mouse mutagenesis, fluorescent reporters to isolate primary cells of interest, low cell number genomics, and proteomic approaches.<\/p>\n<h2>Mentor Training:<\/h2>\n<ul>\n<li>Faculty Mentoring Workshop for Biomedical Researchers<\/li>\n<\/ul>\n<h2>Training Program Affiliations:<\/h2>\n<ul>\n<li>Genetics and Molecular Biology<\/li>\n<\/ul>\n<h2>Publications<\/h2>\n<ul>\n<li><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/1diiwu9QsuG\/bibliography\/47926324\/public\/?sort=date&amp;direction=ascending\">PubMed<\/a><\/strong><\/li>\n<\/ul>\n<h2>Karl Shpargel in UNC Genetics News<\/h2>\n            <div class=\"wc-cards\"><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-february-2026\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 17, 2026<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for February 2026<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 26 papers in February 2026.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for February 2026\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-december-2025\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">February 20, 2026<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for December 2025<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 37 papers in December 2025.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for December 2025\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-december-3rd-16th-2023\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">December 18, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for December 3rd &#8211; 16th, 2023<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 14 papers during December 3rd - 16th 2023.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for December 3rd &#8211; 16th, 2023\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-september-24th-october-7th-2023\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">October 9, 2023<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for September 24th &#8211; October 7th, 2023<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published 12 papers during September 24th - October 7th 2023.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for September 24th &#8211; October 7th, 2023\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/karl-shpargel-phd-promoted-to-associate-professor\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Karl Shpargel, PhD\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">February 22, 2022<\/p><h3 class=\"wc-card__title wc-card__title--3\">Karl Shpargel, PhD Promoted to Associate Professor<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Karl Shpargel has been promoted to Associate Professor in the Department of Genetics, effective January 1, 2022.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Karl Shpargel, PhD Promoted to Associate Professor\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/dr-jason-whitmire-awarded-dod-investigator-initiated-research-award\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"214\" height=\"218\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2021\/07\/JWhitmire.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Jason Whitmire\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">September 9, 2021<\/p><h3 class=\"wc-card__title wc-card__title--3\">Dr. Jason Whitmire awarded DoD Investigator-Initiated Research Award<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Jason Whitmire, PhD (Professor, Department of Genetics, Department of Microbiology &amp; Immunology), was awarded a Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award by the US Army Medical Research Acquisition Activity of the Department of Defense (DoD).<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Dr. Jason Whitmire awarded DoD Investigator-Initiated Research Award\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/karl-shpargel-phd-awarded-new-r01-from-nidcr\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Karl Shpargel, PhD\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">August 25, 2021<\/p><h3 class=\"wc-card__title wc-card__title--3\">Karl Shpargel, PhD Awarded New R01 from NIDCR<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Karl Shpargel (Assistant Professor, Genetics) has been awarded a new R01 grant from the National Institute of Dental and Craniofacial Research (NIDCR) for his project titled \u201cEnhancer activation mechanisms in cranial neural crest osteoblast differentiation\u201d.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Karl Shpargel, PhD Awarded New R01 from NIDCR\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/karl-shpargel-phd-awarded-r01-from-nidcr\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"Karl Shpargel, PhD\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">August 6, 2020<\/p><h3 class=\"wc-card__title wc-card__title--3\">Karl Shpargel, PhD Awarded R56 from NIDCR<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Dr. Karl Shpargel (Assistant Professor, Genetics) was awarded an R56 grant from the National Institute of Dental and Craniofacial Research (NIDCR) for his project titled \u201cEnhancer Activation Roles and Mechanisms in Craniofacial Development\u201d.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Karl Shpargel, PhD Awarded R56 from NIDCR\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-june-14-27-2020\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">June 29, 2020<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for June 14-27, 2020<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published nine papers during June 14-27, 2020.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for June 14-27, 2020\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article><article class=\"wc-card wc-card--1x1 wc-card--zoom\"><a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-march-8-21-2020\/\" class=\"wc-card__link-wrap\"><div class=\"wc-card__image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg\" class=\"attachment-wc_card_1x1 size-wc_card_1x1 wp-post-image\" alt=\"UNC Department of Genetics Logo\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-600x600.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/12\/Genetics-Circle-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\"><\/div><div class=\"wc-card__header\"><p class=\"wc-card__date\">March 23, 2020<\/p><h3 class=\"wc-card__title wc-card__title--3\">Department of Genetics Publications for March 8-21, 2020<\/h3><\/div><div class=\"wc-card__content\"><p class=\"wc-card__excerpt wc-card__excerpt--5\">Department of Genetics faculty, postdocs, students and collaborators published twelve papers during March 8-21, 2020.<\/p><p class=\"wc-card__more\" aria-label=\"Read more about Department of Genetics Publications for March 8-21, 2020\"><span class=\"wc-card__more-text\" aria-hidden=\"true\">Read more<\/span><\/p><\/div><\/a><\/article>            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Keywords:\u00a0chromatin, epigenetics, histone, craniofacial, cancer The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-march-8-21-2020\/\" aria-label=\"Read more about Department of Genetics Publications for March 8-21, 2020\">Read more<\/a><\/p>\n","protected":false},"featured_media":6878,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-3013","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Karl Shpargel, PhD | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Karl Shpargel, PhD | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Research Interests Keywords:\u00a0chromatin, epigenetics, histone, craniofacial, cancer The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-15T18:20:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1856\" \/>\n\t<meta property=\"og:image:height\" content=\"2448\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/\",\"name\":\"Karl Shpargel, PhD | Department of Genetics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg\",\"datePublished\":\"2016-10-24T23:19:24+00:00\",\"dateModified\":\"2025-04-15T18:20:38+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg\",\"width\":1856,\"height\":2448,\"caption\":\"Karl Shpargel, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/genetics\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Karl Shpargel, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/\",\"name\":\"UNC Department of Genetics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/genetics\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\",\"name\":\"UNC Department of Genetics\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png\",\"width\":982,\"height\":151,\"caption\":\"UNC Department of Genetics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Karl Shpargel, PhD | Department of Genetics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/","og_locale":"en_US","og_type":"article","og_title":"Karl Shpargel, PhD | Department of Genetics","og_description":"Research Interests Keywords:\u00a0chromatin, epigenetics, histone, craniofacial, cancer The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/","og_site_name":"Department of Genetics","article_modified_time":"2025-04-15T18:20:38+00:00","og_image":[{"width":1856,"height":2448,"url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/","url":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/","name":"Karl Shpargel, PhD | Department of Genetics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg","datePublished":"2016-10-24T23:19:24+00:00","dateModified":"2025-04-15T18:20:38+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#primaryimage","url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg","contentUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg","width":1856,"height":2448,"caption":"Karl Shpargel, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/genetics\/directory\/karl-shpargel\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/genetics\/"},{"@type":"ListItem","position":2,"name":"Karl Shpargel, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/genetics\/#website","url":"https:\/\/www.med.unc.edu\/genetics\/","name":"UNC Department of Genetics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/genetics\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/genetics\/#organization","name":"UNC Department of Genetics","url":"https:\/\/www.med.unc.edu\/genetics\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png","contentUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png","width":982,"height":151,"caption":"UNC Department of Genetics"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/"}}]}},"_upd_display_name":["Karl Shpargel, PhD"],"_upd_reverse_display_name":["Shpargel, Karl"],"_upd_last_name":["Shpargel"],"_upd_first_name":["Karl"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Associate Professor of Genetics<\/strong>\r\nOffice: Genetic Medicine Building\r\nPhone:\r\n<a class=\"email-link\" title=\"\" href=\"mailto:shpargel@email.unc.edu\" target=\"_self\">Email\u00a0<\/a>"],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"shpargel@email.unc.edu"}]],"_upd_phone":[[{"phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"","address-2":"CB# 7264","campus-box":"","city":"Chapel Hill","state":"NC","zip":"27599-7264"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory\/3013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory\/3013\/revisions"}],"predecessor-version":[{"id":15005,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/directory\/3013\/revisions\/15005"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/media\/6878"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/media?parent=3013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}