{"id":10635,"date":"2021-06-14T09:20:31","date_gmt":"2021-06-14T13:20:31","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=10635"},"modified":"2021-06-14T09:20:31","modified_gmt":"2021-06-14T13:20:31","slug":"department-of-genetics-publications-for-may-30-june-12-2021","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-may-30-june-12-2021\/","title":{"rendered":"Department of Genetics Publications for May 30 \u2013 June 12, 2021"},"content":{"rendered":"

\"UNCDepartment of Genetics faculty, postdocs, students and collaborators published seventeen papers during May 30 \u2013 June 12, 2021.<\/p>\n

 <\/p>\n

PsaF is a membrane-localized pH sensor that regulates\u00a0psaA<\/em>\u00a0expression in\u00a0Y. pestis<\/em>.\u00a0<\/a><\/p>\n

Quinn JD, Weening EH, Miller VL<\/strong>.<\/p>\n

J Bacteriol. 2021 Jun 1:JB0016521. doi: 10.1128\/JB.00165-21. Online ahead of print.<\/p>\n

PMID:\u00a034060904<\/p>\n

 <\/p>\n

The trans-ancestral genomic architecture of glycemic traits.\u00a0<\/a><\/p>\n

Chen J, Spracklen CN<\/strong>, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, M\u00e4gi R, Waage J, Li-Gao R, Chan KHK, Yao J, Anasanti MD, Chu AY, Claringbould A, Heikkinen J, Hong J, Hottenga JJ, Huo S, Kaakinen MA, Louie T, M\u00e4rz W, Moreno-Macias H, Ndungu A, Nelson SC, Nolte IM, North KE, Raulerson CK<\/strong>, Ray D, Rohde R, Rybin D, Schurmann C, Sim X, Southam L, Stewart ID, Wang CA, Wang Y, Wu P, Zhang W, Ahluwalia TS, Appel EVR, Bielak LF, Brody JA, Burtt NP, Cabrera CP, Cade BE, Chai JF, Chai X, Chang LC, Chen CH, Chen BH, Chitrala KN, Chiu YF, de Haan HG, Delgado GE, Demirkan A, Duan Q, Engmann J, Fatumo SA, Gay\u00e1n J, Giulianini F, Gong JH, Gustafsson S, Hai Y, Hartwig FP, He J, Heianza Y, Huang T, Huerta-Chagoya A, Hwang MY, Jensen RA, Kawaguchi T, Kentistou KA, Kim YJ, Kleber ME, Kooner IK, Lai S, Lange LA, Langefeld CD, Lauzon M, Li M, Ligthart S, Liu J, Loh M, Long J, Lyssenko V, Mangino M, Marzi C, Montasser ME, Nag A, Nakatochi M, Noce D, Noordam R, Pistis G, Preuss M, Raffield L<\/strong>, Rasmussen-Torvik LJ, Rich SS, Robertson NR, Rueedi R, Ryan K, Sanna S, Saxena R, Schraut KE, Sennblad B, Setoh K, Smith AV, Spars\u00f8 T, Strawbridge RJ, Takeuchi F, Tan J, Trompet S, van den Akker E, van der Most PJ, Verweij N, Vogel M, Wang H, Wang C, Wang N, Warren HR, Wen W, Wilsgaard T, Wong A, Wood AR, Xie T, Zafarmand MH, Zhao JH, Zhao W, Amin N, Arzumanyan Z, Astrup A, Bakker SJL, Baldassarre D, Beekman M, Bergman RN, Bertoni A, Bl\u00fcher M, Bonnycastle LL, Bornstein SR, Bowden DW, Cai Q, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A, Du S, Eiriksdottir G, Farmaki AE, Fr\u00e5nberg M, Fuchsberger C, Gao Y, Gjesing AP, Goel A, Han S, Hartman CA, Herder C, Hicks AA, Hsieh CH, Hsueh WA, Ichihara S, Igase M, Ikram MA, Johnson WC, J\u00f8rgensen ME, Joshi PK, Kalyani RR, Kandeel FR, Katsuya T, Khor CC, Kiess W, Kolcic I, Kuulasmaa T, Kuusisto J, L\u00e4ll K, Lam K, Lawlor DA, Lee NR, Lemaitre RN, Li H; Lifelines Cohort Study, Lin SY, Lindstr\u00f6m J, Linneberg A, Liu J, Lorenzo C, Matsubara T, Matsuda F, Mingrone G, Mooijaart S, Moon S, Nabika T, Nadkarni GN, Nadler JL, Nelis M, Neville MJ, Norris JM, Ohyagi Y, Peters A, Peyser PA, Polasek O, Qi Q, Raven D, Reilly DF, Reiner A, Rivideneira F, Roll K, Rudan I, Sabanayagam C, Sandow K, Sattar N, Sch\u00fcrmann A, Shi J, Stringham HM, Taylor KD, Teslovich TM, Thuesen B, Timmers PRHJ, Tremoli E, Tsai MY, Uitterlinden A, van Dam RM, van Heemst D, van Hylckama Vlieg A, van Vliet-Ostaptchouk JV, Vangipurapu J, Vestergaard H, Wang T, Willems van Dijk K, Zemunik T, Abecasis GR, Adair LS, Aguilar-Salinas CA, Alarc\u00f3n-Riquelme ME, An P, Aviles-Santa L, Becker DM, Beilin LJ, Bergmann S, Bisgaard H, Black C, Boehnke M, Boerwinkle E, B\u00f6hm BO, B\u00f8nnelykke K, Boomsma DI, Bottinger EP, Buchanan TA, Canouil M, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Cheng CY, Collins FS, Correa A, Cucca F, de Silva HJ, Dedoussis G, Elmst\u00e5hl S, Evans MK, Ferrannini E, Ferrucci L, Florez JC, Franks PW, Frayling TM, Froguel P, Gigante B, Goodarzi MO, Gordon-Larsen P, Grallert H, Grarup N, Grimsgaard S, Groop L, Gudnason V, Guo X, Hamsten A, Hansen T, Hayward C, Heckbert SR, Horta BL, Huang W, Ingelsson E, James PS, Jarvelin MR, Jonas JB, Jukema JW, Kaleebu P, Kaplan R, Kardia SLR, Kato N, Keinanen-Kiukaanniemi SM, Kim BJ, Kivimaki M, Koistinen HA, Kooner JS, K\u00f6rner A, Kovacs P, Kuh D, Kumari M, Kutalik Z, Laakso M, Lakka TA, Launer LJ, Leander K, Li H, Lin X, Lind L, Lindgren C, Liu S, Loos RJF, Magnusson PKE, Mahajan A, Metspalu A, Mook-Kanamori DO, Mori TA, Munroe PB, Nj\u00f8lstad I, O’Connell JR, Oldehinkel AJ, Ong KK, Padmanabhan S, Palmer CNA, Palmer ND, Pedersen O, Pennell CE, Porteous DJ, Pramstaller PP, Province MA, Psaty BM, Qi L, Raffel LJ, Rauramaa R, Redline S, Ridker PM, Rosendaal FR, Saaristo TE, Sandhu M, Saramies J, Schneiderman N, Schwarz P, Scott LJ, Selvin E, Sever P, Shu XO, Slagboom PE, Small KS, Smith BH, Snieder H, Sofer T, S\u00f8rensen TIA, Spector TD, Stanton A, Steves CJ, Stumvoll M, Sun L, Tabara Y, Tai ES, Timpson NJ, T\u00f6njes A, Tuomilehto J, Tusie T, Uusitupa M, van der Harst P, van Duijn C, Vitart V, Vollenweider P, Vrijkotte TGM, Wagenknecht LE, Walker M, Wang YX, Wareham NJ, Watanabe RM, Watkins H, Wei WB, Wickremasinghe AR, Willemsen G, Wilson JF, Wong TY, Wu JY, Xiang AH, Yanek LR, Yengo L, Yokota M, Zeggini E, Zheng W, Zonderman AB, Rotter JI, Gloyn AL, McCarthy MI, Dupuis J, Meigs JB, Scott RA, Prokopenko I, Leong A, Liu CT, Parker SCJ, Mohlke KL<\/strong>, Langenberg C, Wheeler E, Morris AP, Barroso I; Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC).<\/p>\n

Nat Genet. 2021 May 31. doi: 10.1038\/s41588-021-00852-9. Online ahead of print.<\/p>\n

PMID:\u00a034059833<\/p>\n

 <\/p>\n

Author Correction: Highly dampened blood transcriptome response in HIV patients after respiratory infection.\u00a0<\/a><\/p>\n

Sellers SA, Fischer WA 2nd, Heise MT<\/strong>, Schughart K.<\/p>\n

Sci Rep. 2021 May 31;11(1):11844. doi: 10.1038\/s41598-021-90793-4.<\/p>\n

PMID:\u00a034059750<\/p>\n

 <\/p>\n

Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women’s Health Initiative and Atherosclerosis Risk in Communities Study.\u00a0<\/a><\/p>\n

Gondalia R, Baldassari A, Holliday KM, Justice AE, Stewart JD, Liao D, Yanosky JD, Engel SM, Sheps D, Jordahl KM, Bhatti P, Horvath S, Assimes TL, Demerath EW, Guan W, Fornage M, Bressler J, North KE, Conneely KN, Li Y<\/strong>, Hou L, Baccarelli AA, Whitsel EA.<\/p>\n

Environ Res. 2021 Jul;198:111211. doi: 10.1016\/j.envres.2021.111211. Epub 2021 Apr 22.<\/p>\n

PMID:\u00a033895111<\/p>\n

 <\/p>\n

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.\u00a0<\/a><\/p>\n

Mat\u00edas-Garc\u00eda PR, Ward-Caviness CK, Raffield LM<\/strong>, Gao X, Zhang Y, Wilson R, G\u00e0o X, Nano J, Bostom A, Colicino E, Correa A, Coull B, Eaton C, Hou L, Just AC, Kunze S, Lange L, Lange E, Lin X, Liu S, Nwanaji-Enwerem JC, Reiner A, Shen J, Sch\u00f6ttker B, Vokonas P, Zheng Y, Young B, Schwartz J, Horvath S, Lu A, Whitsel EA, Koenig W, Adamski J, Winkelmann J, Brenner H, Baccarelli AA, Gieger C, Peters A, Franceschini N, Waldenberger M.<\/p>\n

Clin Epigenetics. 2021 Jun 2;13(1):121. doi: 10.1186\/s13148-021-01082-w.<\/p>\n

PMID:\u00a034078457<\/p>\n

 <\/p>\n

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.\u00a0<\/a><\/p>\n

Nachun D, Lu AT, Bick AG, Natarajan P, Weinstock J, Szeto MD, Kathiresan S, Abecasis G, Taylor KD, Guo X, Tracy R, Durda P, Liu Y, Johnson C, Rich SS, Van Den Berg D, Laurie C, Blackwell T, Papanicolaou GJ, Correa A, Raffield LM<\/strong>, Johnson AD, Murabito J, Manson JE, Desai P, Kooperberg C, Assimes TL, Levy D, Rotter JI, Reiner AP, Whitsel EA, Wilson JG, Horvath S, Jaiswal S; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.<\/p>\n

Aging Cell. 2021 May 29:e13366. doi: 10.1111\/acel.13366. Online ahead of print.<\/p>\n

PMID:\u00a034050697<\/p>\n

 <\/p>\n

SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.\u00a0<\/a><\/p>\n

Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, Laggner C, Nguyen KT, Zhu Z, Prevatte AW, Barker NK, Herring LE, Davis IJ<\/strong>, Liu P.<\/p>\n

Adv Sci (Weinh). 2021 Jun 1:e2004846. doi: 10.1002\/advs.202004846. Online ahead of print.<\/p>\n

PMID:\u00a034060252<\/p>\n

 <\/p>\n

Impact of prenatal exome sequencing for fetal genetic diagnosis on maternal psychological outcomes and decisional conflict in a prospective cohort.\u00a0<\/a><\/p>\n

Talati AN, Gilmore KL, Hardisty EE, Lyerly AD, Rini C, Vora NL<\/strong>.<\/p>\n

Genet Med. 2021 Apr;23(4):713-719. doi: 10.1038\/s41436-020-01025-5. Epub 2020 Nov 20.<\/p>\n

PMID:\u00a033214710<\/p>\n

 <\/p>\n

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.\u00a0<\/a><\/p>\n

Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, C\u00f3rdova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, Garc\u00eda-Ortiz H, Gieger C, Glaser B, Gonz\u00e1lez-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, J\u00f8rgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Mart\u00ednez-Hern\u00e1ndez A, Meigs JB, Meitinger T, Mendoza-Caamal E, Mohlke KL<\/strong>, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O’Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusi\u00e9-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY; AMP-T2D-GENES Consortia, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O’Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS.<\/p>\n

Nat Commun. 2021 Jun 9;12(1):3505. doi: 10.1038\/s41467-021-23556-4.<\/p>\n

PMID:\u00a034108472<\/p>\n

 <\/p>\n

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.\u00a0<\/a><\/p>\n

Blokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R; Schizophrenia Working Group of the Psychiatric Genomics Consortium, St Clair D, Lencz T, Mowry BJ, Periyasamy S, Cairns MJ, Tooney PA, Wu JQ, Kelly B, Kirov G, Sullivan PF<\/strong>, Corvin A, Riley BP, Esko T, Milani L, J\u00f6nsson EG, Palotie A, Ehrenreich H, Begemann M, Steixner-Kumar A, Sham PC, Iwata N, Weinberger DR, Gejman PV, Sanders AR, Buxbaum JD, Rujescu D, Giegling I, Konte B, Hartmann AM, Bramon E, Murray RM, Pato MT, Lee J, Melle I, Molden E, Ophoff RA, McQuillin A, Bass NJ, Adolfsson R, Malhotra AK; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Martin NG, Fullerton JM, Mitchell PB, Schofield PR, Forstner AJ, Degenhardt F, Schaupp S, Comes AL, Kogevinas M, Guzman-Parra J, Reif A, Streit F, Sirignano L, Cichon S, Grigoroiu-Serbanescu M, Hauser J, Lissowska J, Mayoral F, M\u00fcller-Myhsok B, \u015awi\u0105tkowska B, Schulze TG, N\u00f6then MM, Rietschel M, Kelsoe J, Leboyer M, Jamain S, Etain B, Bellivier F, Vincent JB, Alda M, O’Donovan C, Cervantes P, Biernacka JM, Frye M, McElroy SL, Scott LJ, Stahl EA, Land\u00e9n M, Hamshere ML, Smeland OB, Djurovic S, Vaaler AE, Andreassen OA; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Baune BT, Air T, Preisig M, Uher R, Levinson DF, Weissman MM, Potash JB, Shi J, Knowles JA, Perlis RH, Lucae S, Boomsma DI, Penninx BWJH, Hottenga JJ, de Geus EJC, Willemsen G, Milaneschi Y, Tiemeier H, Grabe HJ, Teumer A, Van der Auwera S, V\u00f6lker U, Hamilton SP, Magnusson PKE, Viktorin A, Mehta D, Mullins N, Adams MJ, Breen G, McIntosh AM, Lewis CM; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium; iPSYCH, Hougaard DM, Nordentoft M, Mors O, Mortensen PB, Werge T, Als TD, B\u00f8rglum AD, Petryshen TL, Smoller JW, Goldstein JM.<\/p>\n

Biol Psychiatry. 2021 Mar 23:S0006-3223(21)01139-2. doi: 10.1016\/j.biopsych.2021.02.972. Online ahead of print.<\/p>\n

PMID:\u00a034099189<\/p>\n

 <\/p>\n

Polygenic Scores and Parental Predictors: An Adult Height Study Based on the United Kingdom Biobank and the Framingham Heart Study.\u00a0<\/a><\/p>\n

You C, Zhou Z, Wen J, Li Y<\/strong>, Pang CH, Du H, Wang Z, Zhou XH, King DA, Liu CT, Huang J.<\/p>\n

Front Genet. 2021 May 21;12:669441. doi: 10.3389\/fgene.2021.669441. eCollection 2021.<\/p>\n

PMID:\u00a034093660<\/p>\n

 <\/p>\n

TLR9- and CD40-Targeting Vaccination Promotes Human B Cell Maturation and IgG Induction\u00a0via<\/em>\u00a0pDC-Dependent Mechanisms in Humanized Mice.\u00a0<\/a><\/p>\n

Cheng L, Li G, Pellegry CM, Yasui F, Li F, Zurawski SM, Zurawski G, Levy Y, Ting JP<\/strong>, Su L.<\/p>\n

Front Immunol. 2021 May 18;12:672143. doi: 10.3389\/fimmu.2021.672143. eCollection 2021.<\/p>\n

PMID:\u00a034093572<\/p>\n

 <\/p>\n

Influenza Virus and SARS-CoV-2 Vaccines.\u00a0<\/a><\/p>\n

Sandor AM<\/strong>, Sturdivant MS, Ting JPY<\/strong>.<\/p>\n

J Immunol. 2021 Jun 1;206(11):2509-2520. doi: 10.4049\/jimmunol.2001287. Epub 2021 May 21.<\/p>\n

PMID:\u00a034021048<\/p>\n

 <\/p>\n

Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits.\u00a0<\/a><\/p>\n

Zhao B, Shan Y, Yang Y, Yu Z, Li T, Wang X, Luo T, Zhu Z, Sullivan P<\/strong>, Zhao H, Li Y, Zhu H.<\/p>\n

Nat Commun. 2021 May 17;12(1):2878. doi: 10.1038\/s41467-021-23130-y.<\/p>\n

PMID:\u00a034001886<\/p>\n

 <\/p>\n

Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength.\u00a0<\/a><\/p>\n

Al-Barghouthi BM, Mesner LD, Calabrese GM, Brooks D, Tommasini SM, Bouxsein ML, Horowitz MC, Rosen CJ, Nguyen K, Haddox S, Farber EA, Onengut-Gumuscu S, Pomp D<\/strong>, Farber CR.<\/p>\n

Nat Commun. 2021 Jun 7;12(1):3408. doi: 10.1038\/s41467-021-23649-0.<\/p>\n

PMID:\u00a034099702<\/p>\n

 <\/p>\n

Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses.\u00a0<\/a><\/p>\n

Paudel S, Liu B, Cummings MJ, Quinn KE, Bazer FW, Caron KM<\/strong>, Wang X.<\/p>\n

Biol Reprod. 2021 Jun 8:ioab110. doi: 10.1093\/biolre\/ioab110. Online ahead of print.<\/p>\n

PMID:\u00a034104954<\/p>\n

 <\/p>\n

RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease.\u00a0<\/a><\/p>\n

Kosinsky RL, Zerche M, Kutschat AP, Nair A, Ye Z, Saul D, von Heesen M, Friton JJ, Schwarzer AC, Paglilla N, Sheikh SZ,<\/strong> Wegwitz F, Sun Z, Ghadimi M, Newberry RD, Sartor RB, Faubion WA, Johnsen SA.<\/p>\n

Cell Death Differ. 2021 Jun 4. doi: 10.1038\/s41418-021-00808-w. Online ahead of print.<\/p>\n

PMID:\u00a034088983<\/p>\n","protected":false},"excerpt":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published seventeen papers during May 30 \u2013 June 12, 2021.<\/p>\n","protected":false},"author":28418,"featured_media":6539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[78,270,100,56,292,36,221,84,104,359,86,64,55,46,321],"class_list":["post-10635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-caron","tag-davis-ij","tag-heise","tag-li","tag-miller-v","tag-mohlke","tag-pomp","tag-raffield","tag-raulerson","tag-sandor","tag-sheikh","tag-spracklen","tag-sullivan","tag-ting","tag-vora","odd"],"acf":[],"yoast_head":"\nDepartment of Genetics Publications for May 30 \u2013 June 12, 2021 | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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