{"id":10777,"date":"2021-08-19T14:15:28","date_gmt":"2021-08-19T18:15:28","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=10777"},"modified":"2021-08-19T14:16:01","modified_gmt":"2021-08-19T18:16:01","slug":"stein-lab-publishes-in-american-journal-of-human-genetics","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/stein-lab-publishes-in-american-journal-of-human-genetics\/","title":{"rendered":"Stein Lab Publishes in American Journal of Human Genetics"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-10778 alignright\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2021\/08\/Stein-and-Aygun.jpg\" alt=\"Jason Stein and Nil Aygun\" width=\"304\" height=\"231\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2021\/08\/Stein-and-Aygun.jpg 615w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2021\/08\/Stein-and-Aygun-300x229.jpg 300w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2021\/08\/Stein-and-Aygun-600x458.jpg 600w\" sizes=\"auto, (max-width: 304px) 100vw, 304px\" \/>The laboratory of Dr. Jason Stein (Assistant Professor, Genetics and Neuroscience Center) published a paper titled <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002929721002792?dgcid=coauthor\">\u201cBrain-trait-associated variants impact cell-type specific gene regulation during neurogenesis\u201d<\/a> in the American Journal of Human Genetics (19 Aug 2021 issue).\u00a0 Led by BCB PhD candidate Nil Aygun, the paper describes mapping e\/sQTLs, and allele-specific expression in cultured cells representing two major developmental stages, primary human neural progenitors (n = 85) and their sorted neuronal progeny (n = 74), identifying numerous loci not detected in either bulk developing cortical wall or adult cortex. Using colocalization and genetic imputation via transcriptome-wide association, the lab uncovered cell-type-specific regulatory mechanisms underlying risk for brain-relevant traits that are active during neocortical differentiation. Specifically, the study identified a progenitor-specific\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/expression-quantitative-trait-loci\">eQTL<\/a>\u00a0for\u00a0<em>CENPW<\/em>\u00a0co-localized with common variant associations for cortical surface area and educational attainment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The laboratory of Dr. Jason Stein (Assistant Professor, Genetics and Neuroscience Center) published a paper titled \u201cBrain-trait-associated variants impact cell-type specific gene regulation during neurogenesis\u201d in the American Journal of Human Genetics (19 Aug 2021 issue).<\/p>\n","protected":false},"author":28418,"featured_media":10778,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[246,33],"class_list":["post-10777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-aygun","tag-stein","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Stein Lab Publishes in American Journal of Human Genetics | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/stein-lab-publishes-in-american-journal-of-human-genetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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