{"id":10819,"date":"2021-08-25T15:26:48","date_gmt":"2021-08-25T19:26:48","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=10819"},"modified":"2021-08-25T15:26:48","modified_gmt":"2021-08-25T19:26:48","slug":"karl-shpargel-phd-awarded-new-r01-from-nidcr","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/karl-shpargel-phd-awarded-new-r01-from-nidcr\/","title":{"rendered":"Karl Shpargel, PhD Awarded New R01 from NIDCR"},"content":{"rendered":"<p class=\"lead\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6878 alignright\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg\" alt=\"Karl Shpargel, PhD\" width=\"218\" height=\"287\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel.jpg 1856w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-227x300.jpg 227w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-776x1024.jpg 776w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-768x1013.jpg 768w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-1165x1536.jpg 1165w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-1553x2048.jpg 1553w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2016\/10\/Karl-Shpargel-600x791.jpg 600w\" sizes=\"auto, (max-width: 218px) 100vw, 218px\" \/>Dr. Karl Shpargel (Assistant Professor, Genetics) has been awarded a new R01 grant from the National Institute of Dental and Craniofacial Research (NIDCR) for his project titled \u201cEnhancer activation mechanisms in cranial neural crest osteoblast differentiation\u201d.<\/p>\n<p>This four-year grant will focus on characterizing <em>de novo<\/em> enhancer activation by chromatin profiling of primary cranial neural crest cells undergoing osteoblast differentiation. Neural crest cells deficient in chromatin-modifying machinery will be analyzed molecularly for disruption of enhancer chromatin states and to identify cooperative functions between these factors. The proposal will utilize a combination of biochemical, genetic, and low cell number genomic approaches to elucidate the role of chromatin-based enhancer activation in craniofacial disorder pathogenesis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Karl Shpargel (Assistant Professor, Genetics) has been awarded a new R01 grant from the National Institute of Dental and Craniofacial Research (NIDCR) for his project titled \u201cEnhancer activation mechanisms in cranial neural crest osteoblast differentiation\u201d.<\/p>\n","protected":false},"author":28418,"featured_media":6878,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[200],"class_list":["post-10819","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-shpargel","odd"],"acf":[],"yoast_head":"<!-- This site is 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