{"id":10975,"date":"2021-10-04T08:20:42","date_gmt":"2021-10-04T12:20:42","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=10975"},"modified":"2021-11-05T09:54:18","modified_gmt":"2021-11-05T13:54:18","slug":"department-of-genetics-publications-september-19th-october-2nd-2021","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-september-19th-october-2nd-2021\/","title":{"rendered":"Department of Genetics Publications September 19th \u2013 October 2nd 2021"},"content":{"rendered":"

\"UNCDepartment of Genetics faculty, postdocs, students and collaborators published 14 papers during September 19th<\/sup> \u2013 October 2nd<\/sup> 2021.<\/p>\n

 <\/p>\n

Ozone-induced changes in the murine lung extracellular vesicle small RNA landscape.\u00a0<\/a><\/p>\n

Smith GJ, Tovar A<\/strong>, Kanke M, Wang Y, Deshane JS, Sethupathy P, Kelada SNP<\/strong>.<\/p>\n

Physiol Rep. 2021 Sep;9(18):e15054. doi: 10.14814\/phy2.15054.<\/p>\n

PMID:\u00a034558223<\/p>\n

 <\/p>\n

Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative.\u00a0<\/a><\/p>\n

Little A, Hu Y, Sun Q, Jain D, Broome J, Chen MH, Thibord F, McHugh C, Surendran P, Blackwell TW, Brody JA, Bhan A, Chami N, Vries PS, Ekunwe L, Heard-Costa N, Hobbs BD, Manichaikul A, Moon JY, Preuss MH, Ryan K, Wang Z, Wheeler M, Yanek LR, Abecasis GR, Almasy L, Beaty TH, Becker LC, Blangero J, Boerwinkle E, Butterworth AS, Choquet H, Correa A, Curran JE, Faraday N, Fornage M, Glahn DC, Hou L, Jorgenson E, Kooperberg C, Lewis JP, Lloyd-Jones DM, Loos RJF, Min N, Mitchell BD, Morrison AC, Nickerson D, North KE, O’Connell JR, Pankratz N, Psaty BM, Vasan RS, Rich SS, Rotter JI, Smith AV, Smith NL, Tang H, Tracy RP, Conomos MP, Laurie CA, Mathias RA, Li Y<\/strong>, Auer PL; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Thornton T, Reiner AP, Johnson AD, Raffield LM.<\/strong><\/p>\n

Hum Mol Genet. 2021 Sep 6:ddab252. doi: 10.1093\/hmg\/ddab252. Online ahead of print.<\/p>\n

PMID:\u00a034553764<\/p>\n

 <\/p>\n

Identification of an ATP-P2X7-mast cell pathway mediating ozone-induced bronchial hyperresponsiveness.\u00a0<\/a><\/p>\n

Kong X, Bennett WC, Jania CM, Chason KD, German Z, Adouli J, Budney SD, Oby BT, van Heusden C, Lazarowski ER, Jaspers I, Randell SH, Hedgespeth BA, Cruse G, Hua X, Schworer SA, Smith GJ, Kelada SNP<\/strong>, Tilley SL.<\/p>\n

JCI Insight. 2021 Sep 21:e140207. doi: 10.1172\/jci.insight.140207. Online ahead of print.<\/p>\n

PMID:\u00a034546976<\/p>\n

 <\/p>\n

Increased Nuchal Translucency: Is Advanced Sequencing the Answer? A Mini Commentary.\u00a0<\/a><\/p>\n

Talati AN, Vora NL<\/strong>.<\/p>\n

BJOG. 2021 Sep 24. doi: 10.1111\/1471-0528.16942. Online ahead of print.<\/p>\n

PMID:\u00a034558159<\/p>\n

 <\/p>\n

High-Dimensional Precision Medicine From Patient-Derived Xenografts.\u00a0<\/a><\/p>\n

Rashid NU, Luckett DJ, Chen J, Lawson MT, Wang L, Zhang Y, Laber EB, Liu Y<\/strong>, Yeh JJ, Zeng D, Kosorok MR.<\/p>\n

J Am Stat Assoc. 2021;116(535):1140-1154. doi: 10.1080\/01621459.2020.1828091. Epub 2020 Nov 12.<\/p>\n

PMID:\u00a034548714\u00a0Free PMC article.<\/strong><\/p>\n

 <\/p>\n

Reducing Ataxic Side Effects from Ventral Intermediate Nucleus of the Thalamus Deep Brain Stimulation Implantation in Essential Tremor: Potential Advantages of Directional Stimulation.\u00a0<\/a><\/p>\n

Roque DA, Hadar E, Zhang Y, Zou F<\/strong>, Murrow R.<\/p>\n

Stereotact Funct Neurosurg. 2021 Sep 15:1-9. doi: 10.1159\/000518238. Online ahead of print.<\/p>\n

PMID:\u00a034535594<\/p>\n

 <\/p>\n

IRF3-mediated pathogenicity in a murine model of human hepatitis A.\u00a0<\/a><\/p>\n

Sun L, Li Y, Misumi I<\/strong>, Gonz\u00e1lez-L\u00f3pez O, Hensley L, Cullen JM, McGivern DR, Matsuda M, Suzuki R, Sen GC, Hirai-Yuki A, Whitmire JK<\/strong>, Lemon SM.<\/p>\n

PLoS Pathog. 2021 Sep 30;17(9):e1009960. doi: 10.1371\/journal.ppat.1009960. Online ahead of print.<\/p>\n

PMID:\u00a034591933<\/p>\n

 <\/p>\n

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.\u00a0<\/a><\/p>\n

Mikhaylova AV, McHugh CP, Polfus LM, Raffield LM<\/strong>, Boorgula MP, Blackwell TW, Brody JA, Broome J, Chami N, Chen MH, Conomos MP, Cox C, Curran JE, Daya M, Ekunwe L, Glahn DC, Heard-Costa N, Highland HM, Hobbs BD, Ilboudo Y, Jain D, Lange LA, Miller-Fleming TW, Min N, Moon JY, Preuss MH, Rosen J, Ryan K, Smith AV, Sun Q, Surendran P, de Vries PS, Walter K, Wang Z, Wheeler M, Yanek LR, Zhong X, Abecasis GR, Almasy L, Barnes KC, Beaty TH, Becker LC, Blangero J, Boerwinkle E, Butterworth AS, Chavan S, Cho MH, Choquet H, Correa A, Cox N, DeMeo DL, Faraday N, Fornage M, Gerszten RE, Hou L, Johnson AD, Jorgenson E, Kaplan R, Kooperberg C, Kundu K, Laurie CA, Lettre G, Lewis JP, Li B, Li Y<\/strong>, Lloyd-Jones DM, Loos RJF, Manichaikul A, Meyers DA, Mitchell BD, Morrison AC, Ngo D, Nickerson DA, Nongmaithem S, North KE, O’Connell JR, Ortega VE, Pankratz N, Perry JA, Psaty BM, Rich SS, Soranzo N, Rotter JI, Silverman EK, Smith NL, Tang H, Tracy RP, Thornton TA, Vasan RS, Zein J, Mathias RA; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Reiner AP, Auer PL.<\/p>\n

Am J Hum Genet. 2021 Sep 23:S0002-9297(21)00306-2. doi: 10.1016\/j.ajhg.2021.08.007. Online ahead of print.<\/p>\n

PMID:\u00a034582791<\/p>\n

 <\/p>\n

HPRep: Quantifying Reproducibility in HiChIP and PLAC-Seq Datasets.\u00a0<\/a><\/p>\n

Rosen JD, Yang Y, Abnousi A, Chen J, Song M, Jones IR, Shen Y, Hu M, Li Y<\/strong>.<\/p>\n

Curr Issues Mol Biol. 2021 Sep 17;43(2):1156-1170. doi: 10.3390\/cimb43020082.<\/p>\n

PMID:\u00a034563051<\/p>\n

 <\/p>\n

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.\u00a0<\/a><\/p>\n

Kapoor PM, Mavaddat N, Choudhury PP, Wilcox AN, Lindstr\u00f6m S, Behrens S, Michailidou K, Dennis J, Bolla MK, Wang Q, Jung A, Abu-Ful Z, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Freeman LEB, Becher H, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bernstein L, Bojesen SE, Brauch H, Brenner H, Br\u00fcning T, Cai Q, Campa D, Canzian F, Carracedo A, Carter BD, Castelao JE, Chanock SJ, Chatterjee N, Chenevix-Trench G, Clarke CL, Couch FJ, Cox A, Cross SS, Czene K, Dai JY, Earp HS, Ekici AB, Eliassen AH, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fritschi L, Gabrielson M, Gago-Dominguez M, Gao C, Gapstur SM, Gaudet MM, Giles GG, Gonz\u00e1lez-Neira A, Gu\u00e9nel P, Haeberle L, Haiman CA, H\u00e5kansson N, Hall P, Hamann U, Hatse S, Heyworth J, Holleczek B, Hoover RN, Hopper JL, Howell A, Hunter DJ; ABCTB Investigators; kConFab\/AOCS Investigators, John EM, Jones ME, Kaaks R, Keeman R, Kitahara CM, Ko YD, Koutros S, Kurian AW, Lambrechts D, Le Marchand L, Lee E, Lejbkowicz F, Linet M, Lissowska J, Llaneza A, MacInnis RJ, Martinez ME, Maurer T, McLean C, Neuhausen SL, Newman WG, Norman A, O’Brien KM, Olshan AF, Olson JE, Olsson H, Orr N, Perou CM<\/strong>, Pita G, Polley EC, Prentice RL, Rennert G, Rennert HS, Ruddy KJ, Sandler DP, Saunders C, Schoemaker MJ, Sch\u00f6ttker B, Schumacher F, Scott C, Scott RJ, Shu XO, Smeets A, Southey MC, Spinelli JJ, Stone J, Swerdlow AJ, Tamimi RM, Taylor JA, Troester MA, Vachon CM, van Veen EM, Wang X, Weinberg CR, Weltens C, Willett W, Winham SJ, Wolk A, Yang XR, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Schmidt MK, Kraft P, Easton DF, Milne RL, Garc\u00eda-Closas M, Chang-Claude J.<\/p>\n

J Natl Cancer Inst. 2021 Mar 1;113(3):329-337. doi: 10.1093\/jnci\/djaa056.<\/p>\n

PMID:\u00a032359158\u00a0Free PMC article.<\/strong><\/p>\n

 <\/p>\n

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.\u00a0<\/a><\/p>\n

Yu X, Li D, Kottur J, Shen Y, Kim HS, Park KS, Tsai YH<\/strong>, Gong W, Wang J, Suzuki K, Parker J<\/strong>, Herring L, Kaniskan H\u00dc, Cai L<\/strong>, Jain R, Liu J, Aggarwal AK, Wang GG, Jin J.<\/p>\n

Sci Transl Med. 2021 Sep 29;13(613):eabj1578. doi: 10.1126\/scitranslmed.abj1578. Epub 2021 Sep 29.<\/p>\n

PMID:\u00a034586829<\/p>\n

 <\/p>\n

Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum.\u00a0<\/a><\/p>\n

Yang Z, Wu H, Lee PH, Tsetsos F, Davis LK, Yu D, Lee SH, Dalsgaard S, Haavik J, Barta C, Zayats T, Eapen V, Wray NR, Devlin B, Daly M, Neale B, B\u00f8rglum AD, Crowley JJ<\/strong>, Scharf J, Mathews CA, Faraone SV, Franke B, Mattheisen M, Smoller JW, Paschou P.<\/p>\n

Biol Psychiatry. 2021 Sep 1;90(5):317-327. doi: 10.1016\/j.biopsych.2020.12.028. Epub 2021 Jan 8.<\/p>\n

PMID:\u00a033714545<\/p>\n

 <\/p>\n

Memes: A motif analysis environment in R using tools from the MEME Suite.\u00a0<\/a><\/p>\n

Nystrom SL, McKay DJ<\/strong>.<\/p>\n

PLoS Comput Biol. 2021 Sep 27;17(9):e1008991. doi: 10.1371\/journal.pcbi.1008991. Online ahead of print.<\/p>\n

PMID:\u00a034570758<\/p>\n

 <\/p>\n

Genomic analysis of “microphenotypes” in epilepsy.\u00a0<\/a><\/p>\n

Stanley K, Hostyk J, Tran L, Amengual-Gual M, Dugan P, Clark J, Choi H, Tchapyjnikov D, Perucca P, Fernandes C, Andrade D, Devinsky O; pSERG Consortium, the EPIGEN Consortium, Cavalleri GL, Depondt C, Sen A, O’Brien T, Heinzen E<\/strong>, Loddenkemper T, Goldstein DB, Mikati MA, Delanty N.<\/p>\n

Am J Med Genet A. 2021 Sep 27. doi: 10.1002\/ajmg.a.62505. Online ahead of print.<\/p>\n

PMID:\u00a034569149<\/p>\n","protected":false},"excerpt":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published 14 papers during September 19th \u2013 October 2nd 2021.<\/p>\n","protected":false},"author":28418,"featured_media":6539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[369,57,274,50,56,88,59,124,267,63,45,30,84,377,114,397,28,321,218,85],"class_list":["post-10975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-cai-l","tag-crowley","tag-heinzen","tag-kelada","tag-li","tag-liu","tag-mckay","tag-misumi","tag-nystrom","tag-parker","tag-perou","tag-publications","tag-raffield","tag-smith-g","tag-tovar","tag-tsai","tag-unc-genetics","tag-vora","tag-whitmire","tag-zou","odd"],"acf":[],"yoast_head":"\nDepartment of Genetics Publications September 19th \u2013 October 2nd 2021 | Department of 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