{"id":11635,"date":"2022-04-12T14:54:43","date_gmt":"2022-04-12T18:54:43","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=11635"},"modified":"2022-04-12T14:54:43","modified_gmt":"2022-04-12T18:54:43","slug":"li-stein-and-zhu-labs-publish-paper-in-nature-genetics","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/li-stein-and-zhu-labs-publish-paper-in-nature-genetics\/","title":{"rendered":"Li, Stein and Zhu Labs Publish Paper in Nature Genetics"},"content":{"rendered":"
\"Yun
Pictured clockwise from top left: Yun Li, Jason Stein, Hongtu Zhu<\/figcaption><\/figure>\n

The laboratories of Drs. Yun Li (Professor, Genetics), Jason Stein (Associate Professor, Genetics) and Hongtu Zhu (Professor, Computer Science and Genetics) published a paper titled \u201cCommon variants contribute to intrinsic human brain functional networks\u201d in Nature Genetics 2022 Apr 7<\/a>.<\/em><\/p>\n

Together with collaborators from around the world and the Biomedical Research Imaging Center<\/a> at UNC, the authors describe a study of 47,276 resting-state functional magnetic resonance (fMRI) images from individuals to discover and validate common genetic variants influencing intrinsic brain activity.\u00a0 They identified 45 new genetic regions associated with brain functional signatures, including associations to the central executive, default mode and salience networks involved in the triple-network model of psychopathology, as well as brain activity-associated loci associated with brain disorders (e.g., the APOE e4 locus with Alzheimer\u2019s disease).\u00a0 Variation in brain function was genetically correlated with major depressive disorder and schizophrenia.<\/p>\n","protected":false},"excerpt":{"rendered":"

The laboratories of Drs. Yun Li (Professor, Genetics), Jason Stein (Associate Professor, Genetics) and Hongtu Zhu (Professor, Computer Science and Genetics) published a paper titled \u201cCommon variants contribute to intrinsic human brain functional networks\u201d in Nature Genetics 2022 Apr 7.<\/p>\n","protected":false},"author":28418,"featured_media":11636,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[56,33,435],"class_list":["post-11635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-li","tag-stein","tag-zhu","odd"],"acf":[],"yoast_head":"\nLi, Stein and Zhu Labs Publish Paper in Nature Genetics | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/li-stein-and-zhu-labs-publish-paper-in-nature-genetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Li, Stein and Zhu Labs Publish Paper in Nature Genetics | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"The laboratories of Drs. Yun Li (Professor, Genetics), Jason Stein (Associate Professor, Genetics) and Hongtu Zhu (Professor, Computer Science and Genetics) published a paper titled \u201cCommon variants contribute to intrinsic human brain functional networks\u201d in Nature Genetics 2022 Apr 7.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/li-stein-and-zhu-labs-publish-paper-in-nature-genetics\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-12T18:54:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/04\/Yun-Li-Jason-Stein-Hongtu-Zhu.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"882\" \/>\n\t<meta property=\"og:image:height\" content=\"917\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Jonathon Cornett\" \/>\n<meta name=\"twitter:card\" 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