{"id":11715,"date":"2022-05-27T08:59:10","date_gmt":"2022-05-27T12:59:10","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=11715"},"modified":"2022-05-27T08:59:10","modified_gmt":"2022-05-27T12:59:10","slug":"unc-chapel-hill-receives-65m-from-nih-for-antiviral-drug-development-center","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/unc-chapel-hill-receives-65m-from-nih-for-antiviral-drug-development-center\/","title":{"rendered":"UNC-Chapel Hill receives $65M from NIH for antiviral drug development center"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-11716\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/05\/HeiseLab.jpeg\" alt=\"Heise Lab\" width=\"1200\" height=\"675\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/05\/HeiseLab.jpeg 1200w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/05\/HeiseLab-300x169.jpeg 300w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/05\/HeiseLab-1024x576.jpeg 1024w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/05\/HeiseLab-768x432.jpeg 768w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/05\/HeiseLab-600x338.jpeg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health awarded the\u00a0<a href=\"https:\/\/sph.unc.edu\/\">UNC Gillings School of Global Public Health<\/a>\u00a0a $65 million grant establishing an Antiviral Drug Discovery Center to develop oral antivirals that can combat pandemic-level viruses like COVID-19. The center builds upon and is tightly affiliated with UNC\u2019s\u00a0<a href=\"https:\/\/www.readdi.org\/\">Rapidly Emerging Antiviral Drug Development Initiative.<\/a><\/p>\n<p>The READDI-AViDD Center, one of nine established by the NIH, is an integrated public-private partnership with a renowned, interdisciplinary research team of experts from the Gillings School, UNC School of Medicine and UNC Eshelman School of Pharmacy. They will apply cutting-edge technologies to develop oral therapies that target viral families with high potential to cause a pandemic in the future.<\/p>\n<p>\u201cBuilding on generous support and vision provided by the North Carolina legislature, the Governor\u2019s office and UNC, we established a collaborative coalition of scientific leaders to develop antiviral drugs against pandemic virus threats of the 21st\u00a0century,\u201d stated\u00a0<a href=\"https:\/\/sph.unc.edu\/adv_profile\/ralph-s-baric-phd\/\">Ralph Baric, Ph.D.<\/a>, program director and William R. Kenan, Jr. Distinguished Professor in epidemiology, microbiology and immunology. \u201cTo achieve these goals, our NIH sponsored READDI-AViDD Center is an international consortium that includes academic institutions, pharmaceutical companies and affiliated entities across five nations who work together to prevent life-threatening human coronavirus, flavivirus, alphavirus and filovirus infections.\u201d<\/p>\n<p>\u201cAt Carolina, we talk about practical applications of our research to improve society and the public good. Faced with the threat of COVID-19, our world-class scientists did not back down,\u201d said UNC-Chapel Hill Chancellor Kevin M. Guskiewicz. \u201cTheir continued pursuit of solutions saved lives, and this recent award recognizes the profound impact of that work. I\u2019m grateful for this funding and the continued support of the N.C. General Assembly, which enables us to perform cutting-edge research and prepare for whatever might be next on the horizon.\u201d<\/p>\n<p>READDI was initially founded and supported through Carolina\u2019s Creativity Hubs initiative and the\u00a0Eshelman Institute for Innovation, and\u00a0<a href=\"https:\/\/pharmacy.unc.edu\/2022\/02\/readdi-receives-18-million-in-north-carolina-state-appropriations-to-advance-antiviral-therapeutics-research\/\">recent funding from the N.C. General Assembly<\/a>\u00a0and support from several members of the N.C. Congressional delegation has been critical in aiding the team\u2019s work. By drawing on expertise and technology from academic and industry partners, including Janssen Pharmaceuticals, Takeda, Chimerix Inc. and Pardes Biosciences, READDI-AC will aid in the discovery and development of broad-spectrum antivirals that reduce the risk of severe illness and death from these highly contagious viruses.<\/p>\n<p>\u201cInvestment in antiviral drug discovery through open science is the best way to ensure that the world is prepared for the next pandemic,\u201d said\u00a0<a href=\"https:\/\/pharmacy.unc.edu\/directory\/tmw20653\/\">Tim Willson, Ph.D.<\/a>, co-director and professor at the UNC Eshelman School of Pharmacy. \u201cREADDI-AC will leverage open science to support the development of antiviral drugs that are affordable and available to all.\u201d<\/p>\n<p>\u201cThe devastating effects of the SARS-CoV-2 pandemic illustrates the critical need for new antiviral treatments for both existing and future viral disease threats,\u201d said\u00a0<a href=\"https:\/\/www.med.unc.edu\/microimm\/directory\/mark-heise-phd\/\">Mark Heise, Ph.D.<\/a>, professor of genetics at the UNC School of Medicine and co-founder of READDI alongside Baric and\u00a0<a href=\"https:\/\/www.med.unc.edu\/microimm\/directory\/nat-morman-phd\/\">Associate Professor of Microbiology and Immunology Nathaniel Moorman, Ph.D<\/a>. \u201cThe READDI-AC Program is poised to significantly enhance our ability to treat existing threats while preparing for future viral disease outbreaks.\u201d<\/p>\n<p>The award is part of NIAD\u2019s\u00a0<a href=\"https:\/\/www.niaid.nih.gov\/research\/antivirals\">Antiviral Program for Pandemics, or APP, an intensive research program designed to speed development of therapeutics for COVID-19<\/a>.<\/p>\n<p>The AViDD centers will conduct research on the early-stage identification and validation of novel viral targets, with an eye to identify small molecules and biotherapeutics that directly block viral targets. As drug candidates are identified and evaluated for properties such as potency and breadth, the most promising will enter late-stage preclinical development. Importantly, the centers can draw on the resources of their industry partners to accelerate research, making use of the companies\u2019 chemical libraries and expertise in moving candidates into the product development pipeline.<\/p>\n<p>The READDI-AC\u2019s consortium of international collaborators also includes the University of Toronto, Diamond Light Source LTD, Sichting VU, Duke University, McGill University, Rutgers University, the University of Alberta, the University of Wisconsin-Madison, University College London, Vanderbilt University and Vanderbilt University Medical Center, the University of Pennsylvania, the University of Maryland-Baltimore County, Oregon Health and Science University, Janssen Pharmaceutica NV, the University of Colorado-Denver, and the University of Tennessee Health Science Center.<\/p>\n<p>Learn more about the nine AViDD centers established by the NIH\u00a0<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-announces-antiviral-drug-development-awards\">here<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number U19AI171292. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.<\/p>\n<p>&nbsp;<\/p>\n<p>This article originally appeared in <a href=\"https:\/\/uncnews.unc.edu\/2022\/05\/20\/unc-chapel-hill-receives-65m-from-nih-for-antiviral-drug-development-center?utm_source=Vital+Signs&amp;utm_campaign=Vital+Signs+5-26-22&amp;utm_medium=email\">UNC News<\/a> from UNC University Communications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The new center will develop antivirals that could combat future pandemic-level viruses<\/p>\n","protected":false},"author":28418,"featured_media":11716,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[100],"class_list":["post-11715","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-heise","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC-Chapel Hill receives $65M from NIH for antiviral drug development center | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/unc-chapel-hill-receives-65m-from-nih-for-antiviral-drug-development-center\/\" \/>\n<meta property=\"og:locale\" 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