{"id":12730,"date":"2023-03-28T12:57:53","date_gmt":"2023-03-28T16:57:53","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=12730"},"modified":"2023-03-28T12:58:35","modified_gmt":"2023-03-28T16:58:35","slug":"nci-awards-earp-pylayeva-gupta-five-year-2-69-million-pancreatic-cancer-research-grant","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/nci-awards-earp-pylayeva-gupta-five-year-2-69-million-pancreatic-cancer-research-grant\/","title":{"rendered":"NCI awards Earp, Pylayeva-Gupta five-year, $2.69 million pancreatic cancer research grant"},"content":{"rendered":"

The National Cancer Institute has awarded UNC Lineberger\u2019s\u00a0Shelley Earp, MD,<\/a>\u00a0and\u00a0Yuliya Pylayeva-Gupta, PhD<\/a>, a\u00a0five-year, $2.69 million R01 research project grant<\/a>\u00a0to investigate approaches to overcome barriers to pancreatic cancer immunotherapies. Their objective is to understand resistance to modern immunotherapy and to design more effective combination therapies.<\/p>\n

\"Headshot
UNC Lineberger\u2019s Shelley Earp, MD.<\/figcaption><\/figure>\n

\u201cThe dismal outcomes of pancreatic cancer are, in part, due to the normal cells that infiltrate tumors; this tumor microenvironment works to thwart the immune system which otherwise could help eliminate cancer,\u201d said Earp, who is director of the cancer center, the Lineberger Professor of Cancer Research and a professor of medicine and pharmacology at the UNC School of Medicine. \u201cSeveral enzymes \u2013 the MerTK, Tyro3 and Axl receptor tyrosine kinases normally help to calm inflammation and repair tissues but in the tumor their action is subverted, and they inhibit the immune response. Our research will focus on the mechanisms by which these kinases hinder the immune response, and we will evaluate new, clinically applicable therapeutic agents that could synergize with current immunotherapies.\u201d<\/p>\n

The MerTK and Axl receptor tyrosine kinases were previously discovered, respectively, by the Earp lab and Edison Liu lab at UNC Lineberger.<\/p>\n

Although the rates of some cancers have declined in the United States during the past few decades, the number of pancreatic cancer cases and deaths have been increasing since the late 1990s.<\/p>\n

\"Headshot
UNC Lineberger\u2019s Yuliya Pylayeva-Gupta, PhD.<\/figcaption><\/figure>\n

The American Cancer Society estimates that more than 64,000 people in the U.S. will be diagnosed with pancreatic cancer this year, and more than 50,000 will die from the disease, making it the fourth leading cause of cancer deaths in the country. It is predicted that pancreatic cancer will become the second leading cause of cancer deaths in the coming decades.<\/p>\n

\u201cCurrent therapies are largely ineffective against pancreatic cancer, and major parts of the problem are suppressive innate immune cells and fibroblasts in the tumor microenvironment,\u201d said Pylayeva-Gupta, UNC School of Medicine associate professor of genetics and co-leader of Lineberger\u2019s Immunology Program. \u201cOur research will focus on answering some challenging questions, including: How do MerTK and Tyro3 kinases function in the innate immune compartment to accelerate pancreatic cancer growth and metastasis? Why does Axl have the opposite effect, and what is the role of Tyro3 in cancer-associated fibroblasts?\u201d<\/p>\n

Earp and Pylayeva-Gupta said the insights they hope to gain through this research could help scientists boost the effectiveness of current immunotherapies and potentially identify new therapeutic approaches to battle pancreatic cancer.<\/p>\n

 <\/p>\n

This article originally appeared in UNC Lineberger Comprehensive Cancer News<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

The National Cancer Institute has awarded UNC Lineberger\u2019s\u00a0Shelley Earp, MD,\u00a0and\u00a0Yuliya Pylayeva-Gupta, PhD, a\u00a0five-year, $2.69 million R01 research project grant\u00a0to investigate approaches to overcome barriers to pancreatic cancer immunotherapies. Their objective is to understand resistance to modern immunotherapy and to design more effective combination therapies.<\/p>\n","protected":false},"author":28418,"featured_media":12731,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[35],"class_list":["post-12730","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pylayeva-gupta","odd"],"acf":[],"yoast_head":"\nNCI awards Earp, Pylayeva-Gupta five-year, $2.69 million pancreatic cancer research grant | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/nci-awards-earp-pylayeva-gupta-five-year-2-69-million-pancreatic-cancer-research-grant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCI awards Earp, Pylayeva-Gupta five-year, $2.69 million pancreatic cancer research grant | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"The National Cancer Institute has awarded UNC Lineberger\u2019s\u00a0Shelley Earp, MD,\u00a0and\u00a0Yuliya Pylayeva-Gupta, PhD, a\u00a0five-year, $2.69 million R01 research project grant\u00a0to investigate approaches to overcome barriers to pancreatic cancer immunotherapies. 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