{"id":12830,"date":"2023-05-07T14:23:07","date_gmt":"2023-05-07T18:23:07","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=12830"},"modified":"2023-05-07T14:23:50","modified_gmt":"2023-05-07T18:23:50","slug":"department-of-genetics-publications-for-april-23rd-may-6th-2023","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-april-23rd-may-6th-2023\/","title":{"rendered":"Department of Genetics Publications for April 23rd \u2013 May 6th, 2023"},"content":{"rendered":"

\"UNCDepartment of Genetics faculty, postdocs, students and collaborators published 11 papers during April 23rd<\/sup> \u2013 May 6th<\/sup>, 2023.<\/p>\n

 <\/p>\n

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice.\u00a0<\/a><\/p>\n

Tran TDB, Monroy Hernandez C, Nguyen H, Wright S; Center for Systems Neurogenetics of Addiction; Tarantino LM<\/strong>, Chesler EJ, Weinstock GM, Zhou Y, Bubier JA.<\/p>\n

Genes Brain Behav. 2023 Apr 27:e12845. doi: 10.1111\/gbb.12845. Online ahead of print.<\/p>\n

PMID:\u00a037114320<\/p>\n

 <\/p>\n

Leveraging base-pair mammalian constraint to understand genetic variation and human disease.\u00a0<\/a><\/p>\n

Sullivan PF<\/strong>, Meadows JRS, Gazal S, Phan BN, Li X, Genereux DP, Dong MX, Bianchi M, Andrews G, Sakthikumar S, Nordin J, Roy A, Christmas MJ, Marinescu VD, Wang C, Wallerman O, Xue J, Yao S, Sun Q, Szatkiewicz J, Wen J<\/strong>, Huckins LM, Lawler A, Keough KC, Zheng Z, Zeng J, Wray NR, Li Y<\/strong>, Johnson J, Chen J; Zoonomia Consortium\u00a7; Paten B, Reilly SK, Hughes GM, Weng Z, Pollard KS, Pfenning AR, Forsberg-Nilsson K, Karlsson EK, Lindblad-Toh K, Andrews G, Armstrong JC, Bianchi M, Birren BW, Bredemeyer KR, Breit AM, Christmas MJ, Clawson H, Damas J, Di Palma F, Diekhans M, Dong MX, Eizirik E, Fan K, Fanter C, Foley NM, Forsberg-Nilsson K, Garcia CJ, Gatesy J, Gazal S, Genereux DP, Goodman L, Grimshaw J, Halsey MK, Harris AJ, Hickey G, Hiller M, Hindle AG, Hubley RM, Hughes GM, Johnson J, Juan D, Kaplow IM, Karlsson EK, Keough KC, Kirilenko B, Koepfli KP, Korstian JM, Kowalczyk A, Kozyrev SV, Lawler AJ, Lawless C, Lehmann T, Levesque DL, Lewin HA, Li X, Lind A, Lindblad-Toh K, Mackay-Smith A, Marinescu VD, Marques-Bonet T, Mason VC, Meadows JRS, Meyer WK, Moore JE, Moreira LR, Moreno-Santillan DD, Morrill KM, Muntan\u00e9 G, Murphy WJ, Navarro A, Nweeia M, Ortmann S, Osmanski A, Paten B, Paulat NS, Pfenning AR, Phan BN, Pollard KS, Pratt HE, Ray DA, Reilly SK, Rosen JR, Ruf I, Ryan L, Ryder OA, Sabeti PC, Sch\u00e4ffer DE, Serres A, Shapiro B, Smit AFA, Springer M, Srinivasan C, Steiner C, Storer JM, Sullivan KAM, Sullivan PF, Sundstr\u00f6m E, Supple MA, Swofford R, Talbot JE, Teeling E, Turner-Maier J, Valenzuela A, Wagner F, Wallerman O, Wang C, Wang J, Weng Z, Wilder AP, Wirthlin ME, Xue JR, Zhang X.<\/p>\n

Science. 2023 Apr 28;380(6643):eabn2937. doi: 10.1126\/science.abn2937. Epub 2023 Apr 28.<\/p>\n

PMID:\u00a037104612<\/p>\n

 <\/p>\n

Evolutionary constraint and innovation across hundreds of placental mammals.\u00a0<\/a><\/p>\n

Christmas MJ, Kaplow IM, Genereux DP, Dong MX, Hughes GM, Li X, Sullivan PF<\/strong>, Hindle AG, Andrews G, Armstrong JC, Bianchi M, Breit AM, Diekhans M, Fanter C, Foley NM, Goodman DB, Goodman L, Keough KC, Kirilenko B, Kowalczyk A, Lawless C, Lind AL, Meadows JRS, Moreira LR, Redlich RW, Ryan L, Swofford R, Valenzuela A, Wagner F, Wallerman O, Brown AR, Damas J, Fan K, Gatesy J, Grimshaw J, Johnson J, Kozyrev SV, Lawler AJ, Marinescu VD, Morrill KM, Osmanski A, Paulat NS, Phan BN, Reilly SK, Sch\u00e4ffer DE, Steiner C, Supple MA, Wilder AP, Wirthlin ME, Xue JR; Zoonomia Consortium\u00a7; Birren BW, Gazal S, Hubley RM, Koepfli KP, Marques-Bonet T, Meyer WK, Nweeia M, Sabeti PC, Shapiro B, Smit AFA, Springer MS, Teeling EC, Weng Z, Hiller M, Levesque DL, Lewin HA, Murphy WJ, Navarro A, Paten B, Pollard KS, Ray DA, Ruf I, Ryder OA, Pfenning AR, Lindblad-Toh K, Karlsson EK, Andrews G, Armstrong JC, Bianchi M, Birren BW, Bredemeyer KR, Breit AM, Christmas MJ, Clawson H, Damas J, Di Palma F, Diekhans M, Dong MX, Eizirik E, Fan K, Fanter C, Foley NM, Forsberg-Nilsson K, Garcia CJ, Gatesy J, Gazal S, Genereux DP, Goodman L, Grimshaw J, Halsey MK, Harris AJ, Hickey G, Hiller M, Hindle AG, Hubley RM, Hughes GM, Johnson J, Juan D, Kaplow IM, Karlsson EK, Keough KC, Kirilenko B, Koepfli KP, Korstian JM, Kowalczyk A, Kozyrev SV, Lawler AJ, Lawless C, Lehmann T, Levesque DL, Lewin HA, Li X, Lind A, Lindblad-Toh K, Mackay-Smith A, Marinescu VD, Marques-Bonet T, Mason VC, Meadows JRS, Meyer WK, Moore JE, Moreira LR, Moreno-Santillan DD, Morrill KM, Muntan\u00e9 G, Murphy WJ, Navarro A, Nweeia M, Ortmann S, Osmanski A, Paten B, Paulat NS, Pfenning AR, Phan BN, Pollard KS, Pratt HE, Ray DA, Reilly SK, Rosen JR, Ruf I, Ryan L, Ryder OA, Sabeti PC, Sch\u00e4ffer DE, Serres A, Shapiro B, Smit AFA, Springer M, Srinivasan C, Steiner C, Storer JM, Sullivan KAM, Sullivan PF, Sundstr\u00f6m E, Supple MA, Swofford R, Talbot JE, Teeling E, Turner-Maier J, Valenzuela A, Wagner F, Wallerman O, Wang C, Wang J, Weng Z, Wilder AP, Wirthlin ME, Xue JR, Zhang X.<\/p>\n

Science. 2023 Apr 28;380(6643):eabn3943. doi: 10.1126\/science.abn3943. Epub 2023 Apr 28.<\/p>\n

PMID:\u00a037104599<\/p>\n

 <\/p>\n

Assessment of a Genomic Assay in Patients With ERBB2-Positive Breast Cancer Following Neoadjuvant Trastuzumab-Based Chemotherapy With or Without Pertuzumab.\u00a0<\/a><\/p>\n

Bueno-Mui\u00f1o C, Echavarr\u00eda I, L\u00f3pez-Tarruella S, Roche-Molina M, Del Monte-Mill\u00e1n M, Massarrah T, Jerez Y, Ayala de la Pe\u00f1a F, Garc\u00eda-S\u00e1enz J\u00c1, Moreno F, Rodr\u00edguez-Lescure \u00c1, Mal\u00f3n-Gim\u00e9nez D, Ballesteros Garc\u00eda AI, Mar\u00edn-Aguilera M, Galv\u00e1n P, Bras\u00f3-Maristany F, Waks AG, Tolaney SM, Mittendorf EA, Vivancos A, Villagrasa P, Parker JS, Perou CM<\/strong>, Par\u00e9 L, Villacampa G, Prat A, Mart\u00edn M.<\/p>\n

JAMA Oncol. 2023 Apr 27. doi: 10.1001\/jamaoncol.2023.0187. Online ahead of print.<\/p>\n

PMID:\u00a037103916<\/p>\n

 <\/p>\n

Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.\u00a0<\/a><\/p>\n

B\u00e1lint L, Nelson-Maney NP, Tian Y, Serafin SD, Caron KM.<\/strong><\/p>\n

Circ Res. 2023 Apr 28;132(9):1185-1202. doi: 10.1161\/CIRCRESAHA.123.321673. Epub 2023 Apr 27.<\/p>\n

PMID:\u00a037104556\u00a0Review.<\/p>\n

 <\/p>\n

Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length.\u00a0<\/a><\/p>\n

Ovchinnikova OG, Treat LP, Teelucksingh T, Clarke BR, Miner TA, Whitfield C, Walker KA, Miller VL.<\/strong><\/p>\n

mBio. 2023 May 4:e0080023. doi: 10.1128\/mbio.00800-23. Online ahead of print.<\/p>\n

PMID:\u00a037140436<\/p>\n

 <\/p>\n

Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor Heterogeneity.\u00a0<\/a><\/p>\n

Swarbrick A, Fernandez-Martinez A, Perou CM.<\/strong><\/p>\n

Cold Spring Harb Perspect Med. 2023 May 3:a041320. doi: 10.1101\/cshperspect.a041320. Online ahead of print.<\/p>\n

PMID:\u00a037137498<\/p>\n

 <\/p>\n

The genetic determinants of recurrent somatic mutations in 43,693 blood genomes.\u00a0<\/a><\/p>\n

Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O’Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, Cade BE, Gilliland FD, Chen Z, Gauderman WJ, Kumar R, Grammer L, Schleimer RP, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Weiss ST, Lasky-Su J, DeMeo DL, Palmer ND, Freedman BI, Bowden DW, Cho MH, Vasan RS, Johnson AD, Yanek LR, Becker LC, Kardia S, He J, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Correa A, Raffield LM<\/strong>, Gao Y, de Andrade M, Rotter JI, Rich SS, Manichaikul AW, Konkle BA, Johnsen JM, Wheeler MM, Custer BS, Duggirala R, Curran JE, Blangero J, Gui H, Xiao S, Williams LK, Meyers DA, Li X, Ortega V, McGarvey S, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Darbar D, Roden D, Albert C, Kooperberg C, Desai P, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Mathias R, Natarajan P, Jaiswal S, Reiner AP, Bick AG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.<\/p>\n

Sci Adv. 2023 Apr 28;9(17):eabm4945. doi: 10.1126\/sciadv.abm4945. Epub 2023 Apr 26.<\/p>\n

PMID:\u00a037126548\u00a0Free PMC article.<\/strong><\/p>\n

 <\/p>\n

Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.\u00a0<\/a><\/p>\n

Patterson V, Ullah F, Bryant L, Griffin JN, Sidhu A, Saliganan S, Blaile M, Saenz MS, Smith R, Ellingwood S, Grange DK, Hu X, Mireguli M, Luo Y, Shen Y, Mulhern M, Zackai E, Ritter A, Izumi K, Hoefele J, Wagner M, Riedhammer KM, Seitz B, Robin NH, Goodloe D, Mignot C, Keren B, Cox H, Jarvis J, Hempel M, Gibson CF, Tran Mau-Them F, Vitobello A, Bruel AL, Sorlin A, Mehta S, Raymond FL, Gilmore K, Powell BC, Weck K<\/strong>, Li C, Vulto-van Silfhout AT, Giacomini T, Mancardi MM, Accogli A, Salpietro V, Zara F, Vora NL<\/strong>, Davis EE, Burdine R, Bhoj E.<\/p>\n

Sci Adv. 2023 Apr 28;9(17):eade0631. doi: 10.1126\/sciadv.ade0631. Epub 2023 Apr 26.<\/p>\n

PMID:\u00a037126546\u00a0Free PMC article.<\/strong><\/p>\n

 <\/p>\n

Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts.\u00a0<\/a><\/p>\n

Vandenberg BN, Laughery MF, Cordero C, Plummer D, Mitchell D, Kreyenhagen J, Albaqshi F, Brown AJ, Mieczkowski PA<\/strong>, Wyrick JJ, Roberts SA.<\/p>\n

Nat Commun. 2023 May 4;14(1):2576. doi: 10.1038\/s41467-023-38255-5.<\/p>\n

PMID:\u00a037142570<\/p>\n

 <\/p>\n

Contribution of Somatic Ras\/Raf\/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.\u00a0<\/a><\/p>\n

Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay EZ, Robert SM, Kiziltug E, Damisah EC, Nelson-Williams C, Zhu G, Kong W, Huang AY, Stronge E, Phillips HW, Chhouk BH, Bizzotto S, Chen MH, Adikari TN, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer IE, Berkovic SF, Haider S, Hildebrand MS, Yang E, Gunel M, Lifton RP, Richardson RM, Bl\u00fcmcke I, Alexandrescu S, Huttner A, Heinzen EL<\/strong>, Zhu J, Poduri A, DeLanerolle N, Spencer DD, Lee EA, Walsh CA, Kahle KT.<\/p>\n

JAMA Neurol. 2023 May 1:e230473. doi: 10.1001\/jamaneurol.2023.0473. Online ahead of print.<\/p>\n

PMID:\u00a037126322\u00a0Free PMC article.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published 11 papers during April 23rd \u2013 May 6th, 2023.<\/p>\n","protected":false},"author":28418,"featured_media":6539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[78,274,82,292,63,45,76,30,84,55,428,74,177,28,321,148,373],"class_list":["post-12830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-caron","tag-heinzen","tag-mieczkowski","tag-miller-v","tag-parker","tag-perou","tag-powell","tag-publications","tag-raffield","tag-sullivan","tag-sun-q","tag-szatkiewicz","tag-tarantino","tag-unc-genetics","tag-vora","tag-weck","tag-wen","odd"],"acf":[],"yoast_head":"\nDepartment of Genetics Publications for April 23rd \u2013 May 6th, 2023 | Department of Genetics<\/title>\n<meta name=\"robots\" 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