{"id":14023,"date":"2024-07-15T08:43:14","date_gmt":"2024-07-15T12:43:14","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=14023"},"modified":"2024-07-15T08:43:35","modified_gmt":"2024-07-15T12:43:35","slug":"nih-award-leads-to-deeper-study-of-brain-malformations","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/","title":{"rendered":"NIH award leads to deeper study of brain malformations"},"content":{"rendered":"<figure id=\"attachment_61641\" class=\"thumbnail wp-caption alignright\" style=\"width: 271px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-61641\" src=\"https:\/\/pharmacy.unc.edu\/wp-content\/uploads\/sites\/1043\/2020\/01\/Heinzen_2021_square-e1637681220171-300x297.jpg\" alt=\"photo of Erin Heinzen\" width=\"271\" height=\"268\" \/><figcaption class=\"caption wp-caption-text\">Erin Heinzen, Pharm.D., Ph.D.<\/figcaption><\/figure>\n<p><span data-contrast=\"none\">How seizures, epilepsy and other brain malformations develop from genetic variants is not fully understood, but a new National Institutes of Health (NIH) award will pave the way toward understanding the cause and potentially lead to new therapies.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">New (non-inherited) genetic variants can arise as cells divide during embryonic development and give rise to mosaicism\u2014sets of cells that are genetically different from one another. Such variants have been shown to cause seizures and brain malformations. The abnormal mosaic brain tissue can sometimes be surgically removed to treat the seizures caused by these genetic variants.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">This new NIH award of more than $<\/span><span data-contrast=\"none\">420,000<\/span><span data-contrast=\"none\">\u00a0will allow for the deep study of individual cells comprising these brain tissue specimens to better understand how these genetic variants cause disease and how we can better treat these conditions.\u00a0\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">This proof-of-concept study will look at tissue comprised of a mixture of cells with and without a genetic variant that causes a rare brain malformation to study the effect of the variant on gene regulation in different types of brain cells.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">This project is led by principal investigator Erin Heinzen, Pharm.D., \u201801, Ph.D. \u201804, associate professor at the UNC Eshelman School of Pharmacy in the Division of Pharmacotherapy and Experimental Therapeutics (DPET) with a joint appointment in the UNC Department of Genetics, in partnership with co-investigator Di Wu, Ph.D., associate professor in the Department of Biostatistics and associate professor at the UNC School of Dentistry.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cOur lab studies the role of somatic variants in epilepsy,\u201d said Heinzen. \u201cThis award will allow us to continue to study the effects of the variants in human brain tissue and identify cell type specific effects that may help us better understand the specific molecular disruptions that lead to disease.\u201d<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The team hypothesizes that their study will reveal reproducible convergent and divergent cell-type-specific disease mechanisms across individuals with the same pathogenic variants and across genes implicated in the same brain malformation. If successful, they will establish a powerful research approach the leverages somatic mosaicism to inform cell types involved in disease, identify the functional changes that accompany neurological and neuropsychiatric diseases and illuminate new therapeutic strategies.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cThe long-term goal of the work is to illuminate transcriptomic changes associated with the pathogenic variant that may direct us toward novel and targeted therapies,\u201d said Heinzen.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\n<p>This article originally appeared in UNC School of Medicine&#8217;s Vital Signs <a href=\"https:\/\/pharmacy.unc.edu\/2024\/06\/nih-award-leads-to-deeper-study-of-brain-malformations\/\">HERE<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Erin Heinzen, Pharm.D., Ph.D. How seizures, epilepsy and other brain malformations develop from genetic variants is not fully understood, but a new National Institutes of Health (NIH) award will pave the way toward understanding the cause and potentially lead to new therapies.\u00a0\u00a0 New (non-inherited) genetic variants can arise as cells divide during embryonic development and &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\" aria-label=\"Read more about NIH award leads to deeper study of brain malformations\">Read more<\/a><\/p>\n","protected":false},"author":28418,"featured_media":12907,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[274],"class_list":["post-14023","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-heinzen","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NIH award leads to deeper study of brain malformations | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NIH award leads to deeper study of brain malformations | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Erin Heinzen, Pharm.D., Ph.D. How seizures, epilepsy and other brain malformations develop from genetic variants is not fully understood, but a new National Institutes of Health (NIH) award will pave the way toward understanding the cause and potentially lead to new therapies.\u00a0\u00a0 New (non-inherited) genetic variants can arise as cells divide during embryonic development and &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-15T12:43:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-15T12:43:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2048\" \/>\n\t<meta property=\"og:image:height\" content=\"2048\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Jonathon Cornett\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jonathon Cornett\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\"},\"author\":{\"name\":\"Jonathon Cornett\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/person\/0291e0ce388bbf007b03c591fc542716\"},\"headline\":\"NIH award leads to deeper study of brain malformations\",\"datePublished\":\"2024-07-15T12:43:14+00:00\",\"dateModified\":\"2024-07-15T12:43:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\"},\"wordCount\":410,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg\",\"keywords\":[\"Heinzen\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\",\"name\":\"NIH award leads to deeper study of brain malformations | Department of Genetics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg\",\"datePublished\":\"2024-07-15T12:43:14+00:00\",\"dateModified\":\"2024-07-15T12:43:35+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg\",\"width\":2048,\"height\":2048,\"caption\":\"Erin Heinzen, PharmD, PhD, Associate Professor\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/genetics\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"NIH award leads to deeper study of brain malformations\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/\",\"name\":\"UNC Department of Genetics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/genetics\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#organization\",\"name\":\"UNC Department of Genetics\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png\",\"width\":982,\"height\":151,\"caption\":\"UNC Department of Genetics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/person\/0291e0ce388bbf007b03c591fc542716\",\"name\":\"Jonathon Cornett\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/98e4bc231fa6040a28baebf18731553c0d5371994059fc719ab66b8c323ce609?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/98e4bc231fa6040a28baebf18731553c0d5371994059fc719ab66b8c323ce609?s=96&d=mm&r=g\",\"caption\":\"Jonathon Cornett\"},\"description\":\"Genetics\",\"url\":\"https:\/\/www.med.unc.edu\/genetics\/author\/jcornett\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"NIH award leads to deeper study of brain malformations | Department of Genetics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/","og_locale":"en_US","og_type":"article","og_title":"NIH award leads to deeper study of brain malformations | Department of Genetics","og_description":"Erin Heinzen, Pharm.D., Ph.D. How seizures, epilepsy and other brain malformations develop from genetic variants is not fully understood, but a new National Institutes of Health (NIH) award will pave the way toward understanding the cause and potentially lead to new therapies.\u00a0\u00a0 New (non-inherited) genetic variants can arise as cells divide during embryonic development and &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/","og_site_name":"Department of Genetics","article_published_time":"2024-07-15T12:43:14+00:00","article_modified_time":"2024-07-15T12:43:35+00:00","og_image":[{"width":2048,"height":2048,"url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg","type":"image\/jpeg"}],"author":"Jonathon Cornett","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jonathon Cornett","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/"},"author":{"name":"Jonathon Cornett","@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/person\/0291e0ce388bbf007b03c591fc542716"},"headline":"NIH award leads to deeper study of brain malformations","datePublished":"2024-07-15T12:43:14+00:00","dateModified":"2024-07-15T12:43:35+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/"},"wordCount":410,"publisher":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg","keywords":["Heinzen"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/","url":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/","name":"NIH award leads to deeper study of brain malformations | Department of Genetics","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg","datePublished":"2024-07-15T12:43:14+00:00","dateModified":"2024-07-15T12:43:35+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#primaryimage","url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg","contentUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg","width":2048,"height":2048,"caption":"Erin Heinzen, PharmD, PhD, Associate Professor"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/genetics\/nih-award-leads-to-deeper-study-of-brain-malformations\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/genetics\/"},{"@type":"ListItem","position":2,"name":"NIH award leads to deeper study of brain malformations"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/genetics\/#website","url":"https:\/\/www.med.unc.edu\/genetics\/","name":"UNC Department of Genetics","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/genetics\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/genetics\/#organization","name":"UNC Department of Genetics","url":"https:\/\/www.med.unc.edu\/genetics\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png","contentUrl":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2018\/11\/Genetics_logo_png_h.png","width":982,"height":151,"caption":"UNC Department of Genetics"},"image":{"@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/person\/0291e0ce388bbf007b03c591fc542716","name":"Jonathon Cornett","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/genetics\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/98e4bc231fa6040a28baebf18731553c0d5371994059fc719ab66b8c323ce609?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/98e4bc231fa6040a28baebf18731553c0d5371994059fc719ab66b8c323ce609?s=96&d=mm&r=g","caption":"Jonathon Cornett"},"description":"Genetics","url":"https:\/\/www.med.unc.edu\/genetics\/author\/jcornett\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1-300x300.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1-768x768.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1-1024x1024.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/06\/Heinzen_2021_square-2048x2048-1-150x150.jpg","featured_image_alt":"Heinzen 2023","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/genetics\/category\/news\/"}],"tag_details":[{"name":"Heinzen","link":"https:\/\/www.med.unc.edu\/genetics\/tag\/heinzen\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/posts\/14023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/users\/28418"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/comments?post=14023"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/posts\/14023\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/media\/12907"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/media?parent=14023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/categories?post=14023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/genetics\/wp-json\/wp\/v2\/tags?post=14023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}