{"id":14311,"date":"2024-09-27T10:33:15","date_gmt":"2024-09-27T14:33:15","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=14311"},"modified":"2024-09-27T10:34:16","modified_gmt":"2024-09-27T14:34:16","slug":"jason-stein-awarded-new-u01-grant-from-nia","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/jason-stein-awarded-new-u01-grant-from-nia\/","title":{"rendered":"Jason Stein Awarded New U01 Grant from NIA"},"content":{"rendered":"<figure id=\"attachment_2936\" class=\"thumbnail wp-caption alignright\" style=\"width: 198px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2936\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/10\/Jason-Stein-188x250.jpeg\" alt=\"Jason Stein, PhD\" width=\"188\" height=\"250\" \/><figcaption class=\"caption wp-caption-text\">Dr. Jason Stein, Associate Professor, Genetics &amp; Neuroscience Center<\/figcaption><\/figure>\n<p class=\"lead\">Dr. Jason Stein (Associate Professor, Genetics and Neuroscience Center) was awarded a new U01 grant from the National Institute of Aging (NIA) for his project titled \u201cAD GxE: in vivo and in vitro modeling of gene x environment interactions\u201d.<\/p>\n<p>Common genetic variants identified through genome-wide association studies have been reproducibly associated with risk for Alzheimer\u2019s disease (AD), but the function of many risk variants are unknown and likely context-specific. At the same time, several environmental exposures have been implicated in AD and dementia, including particulate matter air pollution (PM2.5), heavy metals (especially lead (Pb)), and infections. The hypothesis guiding the study is that the genetic architecture of AD includes gene-environment interactions (GxE) between common, non-coding variants and environmental exposure. The grant proposes to identify these GxE using an in vitro model, &#8220;GxE in a dish&#8221;, using the inherent genetic diversity in a population of neural cells exposed to AD-relevant environmental exposures.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Jason Stein (Associate Professor, Genetics and Neuroscience Center) was awarded a new U01 grant from the National Institute of Aging (NIA) for his project titled \u201cAD GxE: in vivo and in vitro modeling of gene x environment interactions\u201d.\u00a0<\/p>\n","protected":false},"author":28418,"featured_media":2936,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[33],"class_list":["post-14311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-stein","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jason Stein Awarded New U01 Grant from NIA | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/jason-stein-awarded-new-u01-grant-from-nia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jason Stein Awarded New U01 Grant from NIA | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Dr. Jason Stein (Associate Professor, Genetics and Neuroscience Center) was awarded a new U01 grant from the National Institute of Aging (NIA) for his project titled \u201cAD GxE: in vivo and in vitro modeling of gene x environment interactions\u201d.\u00a0\" \/>\n<meta property=\"og:url\" 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