{"id":14957,"date":"2025-04-08T14:27:43","date_gmt":"2025-04-08T18:27:43","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=14957"},"modified":"2025-04-08T14:27:43","modified_gmt":"2025-04-08T18:27:43","slug":"dr-yun-li-and-team-publish-new-model-endoprs-in-ajhg","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/dr-yun-li-and-team-publish-new-model-endoprs-in-ajhg\/","title":{"rendered":"Dr. Yun Li and Team Publish New Model (endoPRS) in AJHG"},"content":{"rendered":"
\"Yun
Yun Li, PhD (Professor, Genetics) and Elena Kharitonova (PhD Student, Biostatistics)<\/figcaption><\/figure>\n

Yun Li, PhD (Professor, Genetics) together with first author Elena Kharitonova (PhD Student, Biostatistics) have published a new paper<\/a> in the American Journal of Human Genetics (AJHG) titled \u201cEndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints \u2013 a study in asthma\u201d.<\/p>\n

\"Yun
Quan Sun, Frank Ockerman, Brian Chen, Micah Hysong, Bjoernar Tuftin, Laura Raffield, & Samir Kelada<\/figcaption><\/figure>\n

This paper introduces endoPRS, \u201ca weighted lasso model that incorporates information from relevant endophenotypes to improve disease risk prediction without making assumptions about the genetic architecture underlying the endophenotype-disease relationship.\u201d\u00a0 The team applied the endoPRS model to predict the risk of childhood-onset asthma in UK Biobank and All of Us data sets by leveraging a paired genome-wide association study of eosinophil count, a relevant endophenotype, and found that endoPRS significantly improves prediction and transferability compared to many existing PRS methods.<\/p>\n","protected":false},"excerpt":{"rendered":"

Yun Li, PhD (Professor, Genetics) together with first author Elena Kharitonova (PhD Student, Biostatistics) have published a new paper in the American Journal of Human Genetics (AJHG) titled \u201cEndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints \u2013 a study in asthma\u201d.\u00a0<\/p>\n","protected":false},"author":28418,"featured_media":14958,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[310,474,50,596,56,597,84,428,598],"class_list":["post-14957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-chen","tag-hysong","tag-kelada","tag-kharitonova","tag-li","tag-ockerman","tag-raffield","tag-sun-q","tag-tuftin","odd"],"acf":[],"yoast_head":"\nDr. Yun Li and Team Publish New Model (endoPRS) in AJHG | Department of 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