{"id":16340,"date":"2025-11-07T15:32:34","date_gmt":"2025-11-07T20:32:34","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=16340"},"modified":"2025-11-07T15:32:34","modified_gmt":"2025-11-07T20:32:34","slug":"xihao-li-and-yiyan-zhang-publish-paper-in-the-american-journal-of-human-genetics","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/xihao-li-and-yiyan-zhang-publish-paper-in-the-american-journal-of-human-genetics\/","title":{"rendered":"Xihao Li and Yiyan Zhang Publish Paper in The American Journal of Human Genetics"},"content":{"rendered":"
\"Xihao
Dr. Xihao Li (Assistant Professor of Genetics & Biostatistics) and Yiyan Zhang (Bioinformatics and Computational Biology Graduate Student in the lab of Yun Li, UNC Genetics)<\/figcaption><\/figure>\n

Dr. Xihao Li (Assistant Professor of Genetics & Biostatistics) and Yiyan Zhang (Bioinformatics and Computational Biology Graduate Student in the lab of Yun Li, UNC Genetics) are authors on a\u00a0newly published manuscript\u00a0titled \u201cA scalable framework for identifying allelic series from summary statistics\u201d.<\/p>\n

The study was led by the insitro Research Team with Yiyan Zhang from UNC BCB Curriculum!<\/p>\n

The publication describes COAST-SS, a new framework for identifying genes that exhibit dose\u2013response relationships, where more deleterious variants are linked to higher disease risk. These \u201callelic series\u201d patterns have guided some of the most successful drug targets, including PCSK9.<\/p>\n

Read publication here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Xihao Li (Assistant Professor of Genetics & Biostatistics) and Yiyan Zhang (Bioinformatics and Computational Biology Graduate Student in the lab of Yun Li, UNC Genetics) are authors on a\u00a0newly published manuscript\u00a0titled \u201cA scalable framework for identifying allelic series from summary statistics\u201d.<\/p>\n","protected":false},"author":28418,"featured_media":16341,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[448,234],"class_list":["post-16340","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-li-x","tag-zhang","odd"],"acf":[],"yoast_head":"\nXihao Li and Yiyan Zhang Publish Paper in The American Journal of Human Genetics | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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