{"id":16480,"date":"2025-12-16T19:18:44","date_gmt":"2025-12-17T00:18:44","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=16480"},"modified":"2025-12-16T19:18:44","modified_gmt":"2025-12-17T00:18:44","slug":"department-of-genetics-publications-for-november-2025","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-november-2025\/","title":{"rendered":"Department of Genetics Publications for November 2025"},"content":{"rendered":"

\"UNCDepartment of Genetics faculty, postdocs, students and collaborators published 29 papers during November 1st – 29th 2025.<\/p>\n

\n
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Immunopeptidomics can inform the design of mRNA vaccines for the delivery of <\/a>Mycobacterium tuberculosis<\/a><\/i>\u00a0MHC class II antigens.\u00a0<\/a><\/p>\n

Leddy O, Ogongo P, Huffaker J, Gan M<\/b>, Milligan R, Mahmud S, Ni HM, Yuki Y, Bobosha K, Wassie L, Carrington M, Liu Q<\/b>, Ernst JD, White FM, Bryson BD.<\/div>\n
Sci Transl Med. 2025 Nov 5;17(823):eadw9184. doi: 10.1126\/scitranslmed.adw9184. Epub 2025 Nov 5. PMID:\u00a041191777<\/div>\n
<\/div>\n
HER2DX in older patients with HER2-positive early breast cancer: extended follow-up from the RESPECT trial of trastuzumab \u00b1 chemotherapy.\u00a0<\/a><\/div>\n
Nozawa K, Sawaki M, Uemura Y, Tsuneizumi M, Takano T, Gondo N, Hara F, Harao M, Toyama T, Taira N, Vivancos A, Perou CM<\/b>, Sanfeliu E, Bras\u00f3-Maristany F, Parker JS, Buckingham W, Par\u00e9 L, Villacampa G, Mar\u00edn-Aguilera M, Villagrasa P, Prat A, Iwata H.<\/div>\n
Nat Commun. 2025 Nov 4;16(1):9585. doi: 10.1038\/s41467-025-65599-x. PMID: 41188218 Free PMC article. Clinical Trial.<\/div>\n
<\/div>\n
HistENCODE: a proposed project to decipher functional interactions among and between histone PTMs.\u00a0<\/a><\/div>\n
Matera AG.<\/b><\/div>\n
Trends Genet. 2025 Nov 4:S0168-9525(25)00259-8. doi: 10.1016\/j.tig.2025.10.005. Online ahead of print. PMID:\u00a041193274<\/div>\n
<\/div>\n
Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.\u00a0<\/a><\/div>\n
Chen Y, Germain RN, Hunter GL, Kulkarni RP, Lander AD, Lowenstein P, Purvis JE<\/b>, Wong HS.<\/div>\n
Cell. 2025 Nov 13;188(23):6393-6410. doi: 10.1016\/j.cell.2025.10.012. PMID: 41237758\u00a0Review.<\/div>\n
<\/div>\n
ELViS: An R Package for Estimating Copy Number Levels of Viral Genomic Segments at Base-Resolution.\u00a0<\/a><\/div>\n
Lee JY, Holt JR, Zhao X, Hoadley KA<\/b>, Hayes DN, Choi HY.<\/div>\n
Bioinformatics. 2025 Nov 12:btaf622. doi: 10.1093\/bioinformatics\/btaf622. Online ahead of print. PMID: 41223153<\/div>\n
<\/div>\n
N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness.\u00a0<\/a><\/div>\n
Robbins JM, Benson M, Verkerke ARP, Tiwari G, Deng S, Rao P, Tahir UA, Avila-Pacheco J, Shi X, Guan Y, Tendoh FG, Barber JL, Miller PE, Perry AS, Hall ME, Wood AC, Taylor KD, Post WS, Rich SS, Nayor M, Wilson JG, Lewis GD, Shah RV, Rotter JI, Summers SA, Raffield LM<\/b>, Kajimura S, Bouchard C, Clish CB, Sarzynski MA, Gerszten RE.<\/div>\n
Circulation. 2025 Nov 12. doi: 10.1161\/CIRCULATIONAHA.125.074187. Online ahead of print. PMID: 41221589<\/div>\n
<\/div>\n
TidyGWAS: a scalable approach for standardized cleaning of genome-wide association study summary statistics.\u00a0<\/a><\/div>\n
Harder A, Guintivano J, Pasman JA, Sullivan PF<\/b>, Lu Y.<\/div>\n
Bioinform Adv. 2025 Oct 27;5(1):vbaf262. doi: 10.1093\/bioadv\/vbaf262. eCollection 2025. PMID: 41221371 Free PMC article.<\/div>\n
<\/div>\n
Genome-wide strand-specific UV mutagenesis in <\/a>Escherichia coli<\/a><\/i>\u00a0is directed by the Mfd translocase.\u00a0<\/a><\/div>\n
Adebali O, Mieczkowski PA<\/b>, Sancar A, Selby CP.<\/div>\n
Proc Natl Acad Sci U S A. 2025 Nov 18;122(46):e2523368122. doi: 10.1073\/pnas.2523368122. Epub 2025 Nov 13.<\/div>\n
PMID: 41231941<\/div>\n
<\/div>\n
APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition.\u00a0<\/a><\/div>\n
Golden LR, Siano DS, Stephens IO, MacLean SM, Saito K, Nolt GL, Funnell JL, Pallerla AV, Lee S, Smith C, Chen J, Zhu H, Voy C, Whitus CM, Hernandez G, Farmer BC, Pandya K, Cowley DO<\/b>, Macauley SL, Gordon SM, Morganti JM, Johnson LA.<\/div>\n
Nat Neurosci. 2025 Nov 11. doi: 10.1038\/s41593-025-02094-y. Online ahead of print. PMID: 41219507<\/div>\n
<\/div>\n
Novel Missense Variant in the FGFR1 Gene Associated With Prenatal Diagnosis of Hartsfield Syndrome.\u00a0<\/a><\/div>\n
Hodges MB, Gilmore KL, Dyke MJ, Vora NL.<\/b><\/div>\n
Prenat Diagn. 2025 Nov 14. doi: 10.1002\/pd.70019. Online ahead of print. PMID: 41238524\u00a0No abstract available.<\/div>\n
<\/div>\n
Clinical characteristics and real-world outcomes in patients with mucopolysaccharidosis II over 18\u00a0years: final report of the Hunter Outcome Survey.\u00a0<\/a><\/div>\n
Muenzer J,<\/b>\u00a0Botha J, Amartino H, Giugliani R, Harmatz P, Kampmann C, Link B, Lin SP, Molter D, Raiman J, Scarpa M, Tylki-Szyma\u0144ska A, Jain S, Whiteman DAH, Burton BK.<\/div>\n
Mol Genet Metab. 2025 Nov 2;146(4):109284. doi: 10.1016\/j.ymgme.2025.109284. Online ahead of print. PMID:\u00a041232197<\/div>\n
<\/div>\n
RL-I2IT: Image-to-image translation with deep reinforcement learning.\u00a0<\/a><\/div>\n
Hu J, Luo Z, Feng C, Hu S, Zhu B, Wu X, Li X, Zhu H<\/b>, Lyu S, Wang X.<\/div>\n
Neural Netw. 2025 Oct 29;195:108264. doi: 10.1016\/j.neunet.2025.108264. Online ahead of print.<\/div>\n
PMID: 41218403<\/div>\n
<\/div>\n
A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium.\u00a0<\/a><\/div>\n
Johri P, <\/b>Charlesworth B.<\/div>\n
Genetics. 2025 Nov 12;231(3):iyaf168. doi: 10.1093\/genetics\/iyaf168. PMID: 40845167 Free PMC article.<\/div>\n
<\/div>\n

Adaptive immune response to West Nile virus infection in the Collaborative Cross mouse model: A database of cellular phenotypes and Quantitative Trait Loci.\u00a0<\/a><\/p>\n

Chamberlin S, Graham J, Jeng S, Swarts J, Ferris M, Heise M<\/b>, Baric RS, McWeeney S, Lund J, Mooney M.<\/p>\n

Sci Data. 2025 Nov 21. doi: 10.1038\/s41597-025-06293-x. Online ahead of print. PMID:\u00a041271835<\/p>\n

<\/div>\n

Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmix.\u00a0<\/a><\/p>\n

Tang C, Sun Q, Zeng X, Li G, Yang X, Liu F, Zhao J, Shen Y, Liu B, Wen J,\u00a0Li Y.<\/b><\/p>\n

Genome Biol. 2025 Nov 20;26(1):395. doi: 10.1186\/s13059-025-03847-5. PMID:\u00a041267097 Free PMC article.<\/p>\n

<\/div>\n

Inferring multi-organ genetic connections using imaging and clinical data through Mendelian randomization.\u00a0<\/a><\/p>\n

Shu J, Zheng R, Chirinos J, Copana C, Li B, Fan Z, Yang X, Yang Y, Wang X, Li Y, Xi B, Li T, Zhu H<\/b>, Zhao B.<\/p>\n

Nat Biomed Eng. 2025 Nov 19. doi: 10.1038\/s41551-025-01554-x. Online ahead of print. PMID:\u00a041258051<\/p>\n

<\/div>\n

RareLink: scalable REDCap-based framework for rare disease interoperability linking international registries to FHIR and Phenopackets.\u00a0<\/a><\/p>\n

Graefe ASL, Rehburg F, Alkarkoukly S, Danis D, Gr\u00f6nke A, H\u00fcbner MR, Bartschke A, Debertsh\u00e4user T, Klopfenstein SAI, Sa\u00df J, Fleck J, Rehberg M, Zsch\u00fcntzsch J, Nyoungui EF, Kalashnikova T, Murgu\u00eda-Favela L, Derfalvi B, Wright NAM, Moosa S, Ogishima S, Semler O, Wiegand S, K\u00fchnen P, Mungall CJ, Haendel MA<\/b>, Robinson PN, Thun S, Beyan O.<\/p>\n

NPJ Genom Med. 2025 Nov 18;10(1):72. doi: 10.1038\/s41525-025-00534-z. PMID: 41253795 Free PMC article.<\/p>\n

<\/div>\n

The missing link: electronic health record linkage across species offers opportunities for improving One Health.\u00a0<\/a><\/p>\n

Mullen KR<\/b>, Saklou N, Kiehl A, Ong TC, Strecker GJ, Toro S<\/b>, VandeWoude S, Brooks IM, Webb TL, Haendel MA.<\/b><\/p>\n

JAMIA Open. 2025 Nov 12;8(6):ooaf151. doi: 10.1093\/jamiaopen\/ooaf151. eCollection 2025 Dec. PMID: 41245152 Free PMC article.<\/p>\n

 <\/p>\n

Building a framework for reproducibility: the case for standardized data reporting and metadata integration in zebrafish research.\u00a0<\/a><\/p>\n

Ngu MS, Toro S<\/b>, Burger A, Ang KC.<\/p>\n

Dis Model Mech. 2025 Nov 1;18(11):dmm052441. doi: 10.1242\/dmm.052441. Epub 2025 Nov 18. PMID: 41250647<\/p>\n

<\/div>\n

Federated double machine learning for high-dimensional semiparametric models.\u00a0<\/a><\/p>\n

Kang K, Wu Z, Qian X, Song X, Zhu H.<\/b><\/p>\n

Biometrics. 2025 Oct 8;81(4):ujaf150. doi: 10.1093\/biomtc\/ujaf150. PMID: 41268645<\/p>\n

<\/div>\n

Evaluation and follow-up of newborns screening positive for mucopolysaccharidosis II: Results from an international modified Delphi consensus.\u00a0<\/a><\/p>\n

Burton BK, Ellinwood NM, Hoffman KK, Muenzer J.<\/b><\/p>\n

Mol Genet Metab. 2025 Nov 12;146(4):109285. doi: 10.1016\/j.ymgme.2025.109285. Online ahead of print. PMID: 41265179<\/p>\n

<\/div>\n

The offonome reveals on and off states of gene expression near the detection limit of RNA-seq.\u00a0<\/a><\/p>\n

Choi WY, Zhao X, Holt J, Jain R, Jo H, Hoadley KA<\/b>, Hayes DN, Choi HY.<\/p>\n

Sci Rep. 2025 Nov 28. doi: 10.1038\/s41598-025-27185-5. Online ahead of print. PMID: 41315666<\/p>\n

<\/div>\n

Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study.\u00a0<\/a><\/p>\n

McLaurin D, Turk P, Affuso O, Raffield LM<\/b>, Heitman E.<\/p>\n

Open Heart. 2025 Nov 27;12(2):e003501. doi: 10.1136\/openhrt-2025-003501. PMID: 41314685<\/p>\n

<\/div>\n

Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival.\u00a0<\/a><\/p>\n

Dzama-Karels M, Sokolowski M, Kuhlers P, Brinkman JA, <\/b>Morris JP 4th, Raab JR.<\/b><\/p>\n

Cell Rep. 2025 Nov 25;44(12):116619. doi: 10.1016\/j.celrep.2025.116619. Online ahead of print. PMID: 41296561<\/p>\n

<\/div>\n

Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity.\u00a0<\/a><\/p>\n

Oh HJ, Sears JD, Ramalingam BM, Saleem RSZ, Davis-Gilbert ZW, Hossain MA, Moorman SR, Ohja D, Martinez SA, Burdick JE<\/b>, Cou\u00f1ago RM, Moorman NJ, Heise MT<\/b>, Todd MH, Willson TM.<\/p>\n

RSC Med Chem. 2025 Oct 31. doi: 10.1039\/d5md00772k. Online ahead of print. PMID: 41292551 Free PMC article.<\/p>\n

<\/div>\n

Association of metabolomics measurements with blood cell phenotypes.\u00a0<\/a><\/p>\n

Chen BD<\/b>, Tapia A, Boerwinkle E, Clish CB, Gerszten R, Graff M, Mohlke KL<\/b>, Morrison AC, Pathmasiri W, Rich SS, Rotter JI, Rushing BR, Sumner S, Tracy RP, Young KL, Yu B, Thyagarajan B, Reiner AP, Li Y, Raffield L.<\/b><\/p>\n

Blood Cells Mol Dis. 2025 Nov 4;117:102966. doi: 10.1016\/j.bcmd.2025.102966. Online ahead of print. PMID: 41289847<\/p>\n

<\/div>\n

Recommendations for responsible use of population descriptors in polygenic risk score development.\u00a0<\/a><\/p>\n

Smith JL, Adebamowo CA, Adebamowo SN, Darst BF, Fullerton SM, Gogarten SM, Hamed ME, Hirbo JB, Hysong MR,<\/b>\u00a0Johar AS, Khan AT, Kullo IJ, Konigsberg IR, Kraft P, Lange LA, Li Y, <\/b>Martin AR, Nelson SC, Choudhury A, Ramsay M, Cobran EK, Schaid DJ, Sharma J, Wang Y, Wojcik GL; Polygenic Risk Methods Development (PRIMED) Consortium; Sun Q.<\/b><\/p>\n

Nat Genet. 2025 Nov 24. doi: 10.1038\/s41588-025-02395-9. Online ahead of print. PMID: 41286102\u00a0Review.<\/p>\n

<\/div>\n

Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation.\u00a0<\/a><\/p>\n

Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q,<\/b>\u00a0Demirkale CY, Heard-Costa NL, Orchard P, Carson AP, Haessler JW, Raffield LM,<\/b>\u00a0Reiner AP,\u00a0Franceschini N,<\/b>\u00a0Auer PL, Kooperberg C, Li Y, <\/b>O’Connor G, Murabito JM, Munson P, Levy D.<\/p>\n

Nat Commun. 2025 Nov 22;16(1):10615. doi: 10.1038\/s41467-025-64336-8. PMID: 41274869 Free PMC article.<\/p>\n

<\/div>\n

Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.\u00a0<\/a><\/p>\n

K\u00fcry S, Stanton JE, van Woerden GM, Bosc-Rosati A, Hsieh TC, Bray L, Oloud\u00e9 M, Rosenfelt C, Scott-Boyer MP, Most V, Wang T, Papendorf JJ, de Konink C, Deb W, Vignard V, Studencka-Turski M, Besnard T, Hajdukowicz AM, Thiel FG, Wolfgramm S, Florenceau L, Cuinat S, Marsac S, Verr\u00e8s Y, Dangoumau A, Poirier L, Wentzensen IM, Tuttle A, Forster C, Striesow J, Golnik R, Ortiz D, Jenkins L, Rosenfeld JA, Ziegler A, Houdayer C, Bonneau D, Torti E, Begtrup A, Monaghan KG, Mullegama SV, Volker-Touw CMLN, van Gassen KLI, Oegema R, de Pagter MS, Steindl K, Rauch A, Ivanovski I, McDonald K, Boothe E, Dauber A, Baker J, Fabie NAV, Bernier RA, Turner TN, Srivastava S, Dies KA, Swanson LC, Costin C, Abdulrazak A, Jobling RK, Pappas J, Rabin R, Niyazov D, Chun-Hui Tsai A, Kovak K, Beck DB, Malicdan MCV, Adams DR, Wolfe L, Ganetzky RD, Muraresku CC, Babikyan D, Sedl\u00e1\u010dek Z, Han\u010d\u00e1rov\u00e1 M, Timberlake AT, Saif HA, Nestler B, King K, Hajianpour MJ, Costain G, Prendergast D, Li C, Genevi\u00e8ve D, Vitobello A, Sorlin A, Philippe C, Harel T, Toker O, Sabir A, Lim D, Hamilton MJ, Bryson LJ, Cleary E, Weber S, Hoffman TL, Cueto-Gonz\u00e1lez AM, Tizzano EF, G\u00f3mez-Andr\u00e9s D, Codina-Sol\u00e0 M, Ververi A, Pavlidou E, Lambropoulos A, Garganis K, Rio M, Levy J, Langas SJ, McRae AM, Lessard MK, D’Agostino MD, De Bie I, Wegler M, Abou Jamra R, Kamphausen SB, Bothe V, Potocki L, Olinger E, Sznajer Y, Wiame E, Thompson ML, Schroeder MC, Gooch C, Smith RA, Pandya A<\/b>, Busch LM, V\u00f6lker U, Hammer E, Wende K, Cogn\u00e9 B, Isidor B, Meiler J, Ripoll C, Bigou S, Laumonnier F, Hildebrand PW, Eichler EE, McWalter K, Krawitz PM, Roux-Dalvai F, Elgersma Y, Marcoux J, Bousquet MP, Droit A, Poschmann J, Grabrucker AM, Bolduc FV, B\u00e9zieau S, Ebstein F, Kr\u00fcger E.<\/p>\n

Nat Commun. 2025 Nov 26;16(1):10545. doi: 10.1038\/s41467-025-65556-8. PMID: 41298377 Free PMC article.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published 29 papers in November 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of Genetics Publications for November 2025 | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-november-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Department of Genetics Publications for November 2025 | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Department of Genetics faculty, postdocs, students and collaborators published 29 papers in November 2025.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-november-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-17T00:18:44+00:00\" 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