{"id":16525,"date":"2026-01-09T10:29:30","date_gmt":"2026-01-09T15:29:30","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=16525"},"modified":"2026-01-09T10:29:30","modified_gmt":"2026-01-09T15:29:30","slug":"five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/","title":{"rendered":"Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects"},"content":{"rendered":"<p class=\"lead\">The UNC School of Medicine Office of Research provided pilot funding to five teams for cutting-edge New Approach Methodologies research.<\/p>\n<hr \/>\n<p>The School of Medicine Office of Research sponsors an annual pilot program,\u00a0<em>Emerging Challenges in Biomedical Research (ECBR),\u00a0<\/em>that provides support for innovative, early-stage research relevant to external strategic priorities. The fall 2025 round of funding was focused on advancing translational biomedical research through the use or development of New Approach Methodologies\/Non-Animal Models (NAMs) and New Approach Technologies (NATs). Previous ECBR rounds have provided pilot support for Basic Science, Health Equity Research, COVID-19, Zika, Alzheimer\u2019s Disease, Precision Healthcare and Vaping research.<\/p>\n<p>Five teams received ECBR funding for cutting-edge NAM\/NAT projects. The teams are:<\/p>\n<p><strong><a href=\"https:\/\/unclineberger.org\/directory\/sarah-shelton\/\">Sarah Shelton, PhD<\/a><\/strong>, assistant professor in the Lampe Joint Department of Biomedical Engineering, with\u00a0<strong><a href=\"https:\/\/unclineberger.org\/directory\/brian-c-miller\/\">Brian Miller, MD, PhD,<\/a><\/strong>\u00a0(Oncology), and\u00a0<strong><a href=\"https:\/\/unclineberger.org\/directory\/gianpietro-dotti\/\">Gianpietro Dotti, MD<\/a><\/strong>\u00a0(Microbiology &amp; Immunology), will develop advanced tissue-on-chip models to improve CAR T cell therapy for solid tumors. Their project,\u00a0<strong><em>A New Approach Method for the Discovery of Targets to Improve CAR T Cell Therapy<\/em><\/strong>, aims to enhance CAR T cell infiltration into the tumor microenvironment and identify pathways for engineering more effective therapies.<\/p>\n<p><strong><a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/douglas-cyr-phd\/\">Douglas M. Cyr, PhD<\/a><\/strong>, professor in the Department of Cell Biology and Physiology, leads the project,\u00a0<strong><em>The Mechanism for ProSP-CI73T Proteotoxicity in Idiopathic Lung Fibrosis<\/em><\/strong>. Using induced pluripotent stem cell-derived alveolar epithelial cells, the team will uncover how a common surfactant protein mutation disrupts cell homeostasis and drives IPF onset, paving the way for new therapeutic strategies.<\/p>\n<p><strong><a href=\"https:\/\/www.med.unc.edu\/pathology\/directory\/vaziri\/\">Cyrus Vaziri, PhD<\/a><\/strong>, professor in Pathology &amp; Laboratory Medicine, with\u00a0<strong><a href=\"https:\/\/unclineberger.org\/directory\/jessica-l-bowser\/\">Jessica Bowser, PhD<\/a><\/strong>\u00a0(Pathology), and\u00a0<strong><a href=\"https:\/\/www.med.unc.edu\/obgyn\/people\/victoria-bae-jump\/\">Victoria Bae-Jump, MD, PhD<\/a><\/strong>\u00a0(OBGYN\/Oncology), will investigate metastatic cancer biology in their proposal,\u00a0<strong><em>Defining Molecular Vulnerabilities of Metastatic Cancer Spheroids Using Non-Animal Models<\/em><\/strong>. By leveraging patient-relevant 3D spheroid systems, the team seeks to identify protein kinase signaling pathways that sustain metastatic spread and reveal actionable targets for therapy.<\/p>\n<p><strong><a href=\"https:\/\/www.med.unc.edu\/microimm\/people\/sarah-rowe-conlon-phd\/\">Sarah Rowe-Conlon, PhD<\/a><\/strong>, associate professor in Microbiology and Immunology, with collaborators\u00a0<strong><a href=\"https:\/\/www.med.unc.edu\/medicine\/infdis\/people\/tessa-andermann\/\">Tessa Andermann, MD, MPH<\/a>,<\/strong>\u00a0(Medicine\/Infectious Diseases), and\u00a0<strong><a href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/adriana-beltran\/\">Adriana Beltran, PhD<\/a><\/strong>\u00a0(Genetics\/HPCC), will create a human liver organoid model to study hypervirulent\u00a0<em>Klebsiella pneumoniae<\/em>. Their project,\u00a0<strong><em>Human Liver Organoid Model to Phenotype Hypervirulent Klebsiella pneumoniae Clinical Isolates<\/em><\/strong>, will improve detection of high-risk strains and reduce reliance on animal models for infection research.<\/p>\n<p><strong><a href=\"https:\/\/www.med.unc.edu\/childrensresearch\/directory\/timothy-p-moran-md-phd\/\">Timothy P. Moran, MD, PhD<\/a><\/strong>, associate professor in Pediatrics, with\u00a0<strong><a href=\"https:\/\/www.med.unc.edu\/childrensresearch\/directory\/mike-kulis-phd\/\">Michael Kulis, PhD<\/a><\/strong>\u00a0(Peds),\u00a0<strong><a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/scott-randell-phd\/\">Scott Randell, PhD<\/a><\/strong>\u00a0(Cell Biology &amp; Physiology),\u00a0<strong><a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/phillip-clapp-phd\/\">Phillip Clapp, PhD<\/a><\/strong>\u00a0(Cell Biology &amp; Physiology),\u00a0<a href=\"https:\/\/www.med.unc.edu\/ent\/directory\/adam-j-kimple-md\/\">Adam Kimple, MD, PhD<\/a>\u00a0(Otolaryngology), will develop human lymphoid organoids to study food allergy immunotherapy. Their proposal,\u00a0<strong><em>Development of a Human Lymphoid Organoid Model to Study Food Allergy Immunotherapy<\/em><\/strong>, aims to identify Th1-promoting adjuvants that enhance the efficacy of sublingual immunotherapy for peanut allergy.<\/p>\n<p>More about the ECBR mechanism and other funding provided by the Office of Research\u00a0<a href=\"https:\/\/www.med.unc.edu\/oor\/research\/funding\/\">can be found here<\/a>.<\/p>\n<p>This article originally appeared in the January 8, 2026 issue of UNC Vital Signs <strong><a href=\"https:\/\/news.unchealthcare.org\/2026\/01\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\">HERE<\/a><\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The School of Medicine Office of Research sponsors an annual pilot program, Emerging Challenges in Biomedical Research (ECBR), that provides support for innovative, early-stage research relevant to external strategic priorities. The fall 2025 round of funding was focused on advancing translational biomedical research through the use or development of New Approach Methodologies\/Non-Animal Models (NAMs) and New Approach Technologies (NATs).<\/p>\n","protected":false},"author":28418,"featured_media":12239,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[287],"class_list":["post-16525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-beltran","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"The School of Medicine Office of Research sponsors an annual pilot program, Emerging Challenges in Biomedical Research (ECBR), that provides support for innovative, early-stage research relevant to external strategic priorities. The fall 2025 round of funding was focused on advancing translational biomedical research through the use or development of New Approach Methodologies\/Non-Animal Models (NAMs) and New Approach Technologies (NATs).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-09T15:29:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2022\/11\/Adriana-Beltran-2022-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2418\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Jonathon Cornett\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" 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