{"id":16659,"date":"2026-02-13T15:53:52","date_gmt":"2026-02-13T20:53:52","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=16659"},"modified":"2026-02-13T15:54:37","modified_gmt":"2026-02-13T20:54:37","slug":"valdar-awarded-new-r01-mpi-from-niddk","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/valdar-awarded-new-r01-mpi-from-niddk\/","title":{"rendered":"Valdar Awarded New R01 (MPI) from NIDDK"},"content":{"rendered":"<figure id=\"attachment_13129\" class=\"thumbnail wp-caption alignright\" style=\"width: 198px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-13129 size-full\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2023\/09\/William-Valdar.jpeg\" alt=\"William Valdar\" width=\"188\" height=\"250\" \/><figcaption class=\"caption wp-caption-text\">Dr. Will Valdar (Professor, Genetics and Biostatistics)<\/figcaption><\/figure>\n<p class=\"lead\">Dr. Will Valdar (Professor, Genetics and Biostatistics), together with Paul Watkins (Pharmacy) and Chengwen Li (Pediatrics), was awarded a new R01 MPI grant from NIDDK for their project titled \u201cGenetic determinants of AAV liver transduction and toxicity\u201d.<\/p>\n<p>This four-year award starts 2\/15\/2026. \u00a0The central hypothesis is that Collaborative Cross mice inter-strain susceptibility to AAV hepatotoxicity and transgene expression will be mirrored in cultured hepatocyte spheroids prepared from the strains and that combining in vivo and hepatocyte spheroid data will provide new insights that will improve the safety and efficacy of AAV gene therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Will Valdar (Professor, Genetics and Biostatistics), together with Paul Watkins (Pharmacy) and Chengwen Li (Pediatrics), was awarded a new R01 MPI grant from NIDDK for their project titled \u201cGenetic determinants of AAV liver transduction and toxicity\u201d.<\/p>\n","protected":false},"author":28418,"featured_media":9766,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[99],"class_list":["post-16659","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-valdar","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Valdar Awarded New R01 (MPI) from NIDDK | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/valdar-awarded-new-r01-mpi-from-niddk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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