{"id":2689,"date":"2017-01-03T20:04:11","date_gmt":"2017-01-04T01:04:11","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/genetics-faculty-publications-for-december-2016\/"},"modified":"2018-02-07T11:11:35","modified_gmt":"2018-02-07T16:11:35","slug":"genetics-faculty-publications-for-december-2016","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/genetics-faculty-publications-for-december-2016\/","title":{"rendered":"Genetics Faculty Publications for December 2016"},"content":{"rendered":"

<\/p>\n

December was a very productive month for the Department of Genetics faculty, who published 30 manuscripts on a wide variety of topics.<\/p>\n

<\/div>\n

An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.<\/a><\/span><\/p>\n

Snouwaert JN, Nguyen M, Repenning PW, Dye R, Livingston EW, Kovarova M, Moy SS, Brigman BE, Bateman TA, Ting JP, Koller BH<\/b>.
\nCell Rep. 2016 Dec 13;17(11):3077-3088. doi: 10.1016\/j.celrep.2016.11.052.
\nPMID: 27974218<\/p>\n

Ticking in Place for the Microbiome to Message Out<\/a><\/p>\n

Liang X, Bultman SJ.
\n<\/b>Cell Metab. 2016 Dec 13;24(6):775-777. doi: 10.1016\/j.cmet.2016.11.015
\n<\/b>PMID: 27974176<\/p>\n

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.<\/a><\/p>\n

Floyd JS, Sitlani CM, Avery CL, Noordam R, Li X, Smith AV, Gogarten SM, Li J, Broer L, Evans DS, Trompet S, Brody JA, Stewart JD, Eicher JD, Seyerle AA, Roach J, Lange LA, Lin HJ, Kors JA, Harris TB, Li-Gao R, Sattar N, Cummings SR, Wiggins KL, Napier MD, St\u00fcrmer T, Bis JC, Kerr KF, Uitterlinden AG, Taylor KD, Stott DJ, de Mutsert R, Launer LJ, Busch EL, M\u00e9ndez-Gir\u00e1ldez R, Sotoodehnia N, Soliman EZ, Li Y, Duan Q, Rosendaal FR, Slagboom PE, Wilhelmsen KC,<\/b> Reiner AP, Chen YD, Heckbert SR, Kaplan RC, Rice KM, Jukema JW, Johnson AD, Liu Y, Mook-Kanamori DO, Gudnason V, Wilson JG, Rotter JI, Laurie CC, Psaty BM, Whitsel EA, Cupples LA, Stricker BH.
\nPharmacogenomics J. 2016 Dec 13. doi: 10.1038\/tpj.2016.90. [Epub ahead of print]\nPMID: 27958378<\/p>\n

Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression.<\/a><\/p>\n

Zhang G, Huang KC, Xu Z, Tzeng JY, Conneely KN, Guan W, Kang J, Li Y
\n<\/b>Genet Epidemiol. 2016 May;40(4):333-40. doi: 10.1002\/gepi.21969.
\nPMID: 27061717<\/p>\n

Epigenetic Regulation by ATP-Dependent Chromatin-Remodeling Enzymes: SNF-ing Out Crosstalk.<\/a><\/p>\n

Runge JS, Raab JR, Magnuson T<\/b>.
\nCurr Top Dev Biol. 2016;117:1-13. doi: 10.1016\/bs.ctdb.2015.10.009. Review.
\nPMID: 26969969<\/p>\n

HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants.<\/a><\/p>\n

Xu Z, Zhang G, Duan Q, Chai S, Zhang B, Wu C, Jin F, Yue F, Li Y<\/strong>, Hu M.
\nBMC Res Notes. 2016 Mar 11;9:159. doi: 10.1186\/s13104-016-1947-0.
\nPMID: 26969411<\/p>\n

CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.<\/a><\/p>\n

Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, Morrison C, Heise MT<\/strong>, He W, Miller MS, Lin X.
\nCell Rep. 2016 Mar 15;14(10):2389-401. doi: 10.1016\/j.celrep.2016.02.031.
\nPMID: 26947079<\/p>\n

Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM\/9906 sub-study.<\/a><\/p>\n

Martin M, Brase JC, Ruiz A, Prat A, Kronenwett R, Calvo L, Petry C, Bernard PS, Ruiz-Borrego M, Weber KE, Rodriguez CA, Alvarez IM, Segui MA, Perou CM, <\/b>Casas M, Carrasco E, Caballero R, Rodriguez-Lescure A.
\nBreast Cancer Res Treat. 2016 Feb;156(1):81-9. doi: 10.1007\/s10549-016-3725-z.
\nPMID: 26909792<\/p>\n

One CNV Discordance in NRXN1 Observed Upon Genome-wide Screening in 38 Pairs of Adult Healthy Monozygotic Twins.<\/a><\/p>\n

Magnusson PK, Lee D, Chen X, Szatkiewicz J, Pramana S, Teo S, Sullivan PF<\/strong>, Feuk L, Pawitan Y.
\nTwin Res Hum Genet. 2016 Apr;19(2):97-103. doi: 10.1017\/thg.2016.5.
\nPMID: 26899349<\/p>\n

Generating a taxonomy for genetic conditions relevant to reproductive planning.<\/a><\/p>\n

Korngiebel DM, McMullen CK, Amendola LM, Berg JS<\/strong>, Davis JV, Gilmore MJ, Harding CO, Himes P, Jarvik GP, Kauffman TL, Kennedy KA, Simpson DK, Leo MC, Lynch FL, Quigley DI, Reiss JA, Richards CS, Rope AF, Schneider JL, Goddard KA, Wilfond BS.
\nAm J Med Genet A. 2016 Mar;170(3):565-73. doi: 10.1002\/ajmg.a.37513.
\nPMID: 26889673<\/p>\n

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.<\/a><\/p>\n

Pers TH, Timshel P, Ripke S, Lent S, Sullivan PF<\/b>, O’Donovan MC, Franke L, Hirschhorn JN; Schizophrenia Working Group of the Psychiatric Genomics Consortium.
\nHum Mol Genet. 2016 Mar 15;25(6):1247-54. doi: 10.1093\/hmg\/ddw007.
\nPMID: 26755824<\/p>\n

Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.<\/a><\/span><\/p>\n

Percival CJ, Liberton DK, Pardo-Manuel de Villena F<\/strong>, Spritz R, Marcucio R, Hallgr\u00edmsson B.
\nJ Anat. 2016 Jan;228(1):96-112. doi: 10.1111\/joa.12382.
\nPMID: 26426826<\/p>\n

Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.<\/a><\/p>\n

Zhou F, Shen C, Xu J, Gao J, Zheng X, Ko R, Dou J, Cheng Y, Zhu C, Xu S, Tang X, Zuo X, Yin X<\/strong>, Cui Y, Sun L, Tsoi LC, Hsu YH, Yang S, Zhang X.
\nClin Epigenetics. 2016 Dec 5;8:131.
\nPMID: 27980695<\/p>\n

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.<\/a><\/p>\n

Hoopes JI, Cortez LM, Mertz TM, Malc EP, Mieczkowski PA<\/b>, Roberts SA.
\nCell Rep. 2016 Feb 16;14(6):1273-82. doi: 10.1016\/j.celrep.2016.01.021.
\nPMID: 26832400<\/p>\n

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.<\/a><\/p>\n

Demaria M, O’Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE<\/b>, Muss H, Campisi J.
\nCancer Discov. 2016 Dec 15. pii: CD-16-0241. [Epub ahead of print]\nPMID: 27979832<\/p>\n

Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice.<\/a><\/span><\/p>\n

Pawlak JB, Wetzel-Strong SE, Dunn MK, Caron KM<\/strong>.
\nPeptides. 2016 Dec 8. pii: S0196-9781(16)30238-8. doi: 10.1016\/j.peptides.2016.12.002. [Epub ahead of print]\nPMID: 27940069<\/p>\n

Mucopolysaccharidosis Type I Newborn Screening: Best Practices for Diagnosis and Management.<\/a><\/span><\/p>\n

Clarke LA, Atherton AM, Burton BK, Day-Salvatore DL, Kaplan P, Leslie ND, Scott CR, Stockton DW, Thomas JA, Muenzer J<\/b>.
\nJ Pediatr. 2016 Dec 7. pii: S0022-3476(16)31265-3. doi: 10.1016\/j.jpeds.2016.11.036. [Epub ahead of print] No abstract available.
\nPMID: 27939258<\/p>\n

Dual Chromatin and Cytoskeletal Remodeling by SETD2.<\/a><\/p>\n

Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK<\/b>, Walker CL.
\nCell. 2016 Aug 11;166(4):950-62. doi: 10.1016\/j.cell.2016.07.005
\nPMID: 27518565<\/p>\n

Survival of children with trisomy 13 and trisomy 18: A multi-state population-based study.<\/a><\/span><\/p>\n

Meyer RE, Liu G, Gilboa SM, Ethen MK, Aylsworth AS, Powell CM<\/b>, Flood TJ, Mai CT, Wang Y, Canfield MA; National Birth Defects Prevention Network.
\nAm J Med Genet A. 2016 Apr;170A(4):825-37. doi: 10.1002\/ajmg.a.37495.
\nPMID: 26663415<\/p>\n

DeFCoM: Analysis and Modeling of Transcription Factor Binding Sites Using a Motif-centric Genomic Footprinter.<\/a><\/p>\n

Quach B, Furey TS<\/b>.
\nBioinformatics. 2016 Dec 19. pii: btw740. [Epub ahead of print]\nPMID: 27993786<\/p>\n

Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction.<\/a><\/p>\n

Hatkevich T, Kohl KP, McMahan S, Hartmann MA, Williams AM, Sekelsky J<\/b>.
\nCurr Biol. 2016 Dec 9. pii: S0960-9822(16)31289-1. doi: 10.1016\/j.cub.2016.10.055. [Epub ahead of print]\nPMID: 27989672<\/p>\n

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.<\/a><\/p>\n

Guo H, K\u00f6nig R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP.
\n<\/strong>Cell Host Microbe. 2016 Apr 13;19(4):515-28. doi: 10.1016\/j.chom.2016.03.001.
\nPMID: 27078069<\/p>\n

BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.<\/a><\/span><\/p>\n

Graff M, North KE, Richardson AS, Young KL, Mazul AL, Highland HM, Mohlke K<\/strong>L, Lange LA, Lange EM, Harris KM, Gordon-Larsen P.
\nInt J Obes (Lond). 2016 Dec 27. doi: 10.1038\/ijo.2016.233. [Epub ahead of print]\nPMID: 28025578<\/p>\n

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.<\/a><\/p>\n

Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai FJ, Li S, Wu Y, Wu T, Kim S, Guo X, Liang J, Shungin D, Adair LS, Akiyama K, Allison M, Cai Q, Chang LC, Chen CH, Chen YT, Cho YS, Choi BY, Gao Y, Go MJ, Gu D, Han BG, He M, Hixson JE, Hu Y, Huang T, Isono M, Jung KJ, Kang D, Kim YJ, Kita Y, Lee J, Lee NR, Lee J, Wang Y, Liu JJ, Long J, Moon S, Nakamura Y, Nakatochi M, Ohnaka K, Rao D, Shi J, Sull JW, Tan A, Ueshima H, Wu C, Xiang YB, Yamamoto K, Yao J, Ye X, Yokota M, Zhang X, Zheng Y, Qi L, Rotter JI, Jee SH, Lin D, Mohlke KL,<\/strong> He J, Mo Z, Wu JY, Tai ES, Lin X, Miki T, Kim BJ, Takeuchi F, Zheng W, Shu XO.
\nSci Rep. 2016 Jan 20;6:17958. doi: 10.1038\/srep17958.
\nPMID: 26785701<\/p>\n

Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.<\/a><\/p>\n

Below JE, Parra EJ, Gamazon ER, Torres J, Krithika S, Candille S, Lu Y, Manichakul A, Peralta-Romero J, Duan Q, Li Y<\/b>, Morris AP, Gottesman O, Bottinger E, Wang XQ, Taylor KD, Ida Chen YD, Rotter JI, Rich SS, Loos RJ, Tang H, Cox NJ, Cruz M, Hanis CL, Valladares-Salgado A.
\nSci Rep. 2016 Jan 19;6:19429. doi: 10.1038\/srep19429.
\nPMID: 26780889<\/p>\n

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine\/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection.<\/a><\/p>\n

Maas BM, Francis O, Mollan KR, Lee C, Cottrell ML, Prince HM, Sykes C, Trezza C, Torrice C, White N, Malone S, Hudgens MG, Sharpless NE<\/b>, Dumond JB.
\nPLoS One. 2016 Dec 30;11(12):e0168709. doi: 10.1371\/journal.pone.0168709.
\nPMID: 28036343<\/p>\n

Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV-Infected Subjects With Aging Biomarkers.<\/a><\/p>\n

Dumond JB, Chen J, Cottrell M, Trezza CR, Prince H, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Sharpless NE,<\/strong> Forrest A.
\nCPT Pharmacometrics Syst Pharmacol. 2016 Dec 29. doi: 10.1002\/psp4.12151. [Epub ahead of print]\nPMID: 28032946<\/p>\n

p16INK4a<\/sup> , a Senescence Marker, Influences Tenofovir\/Emtricitabine Metabolite Disposition in HIV-Infected Subjects.<\/a><\/p>\n

Dumond JB, Collins JW, Cottrell ML, Trezza CR, Prince H, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Sharpless NE<\/b>, Forrest A.
\nCPT Pharmacometrics Syst Pharmacol. 2016 Dec 26. doi: 10.1002\/psp4.12150. [Epub ahead of print]\nPMID: 28019088<\/p>\n

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties.<\/a><\/span><\/p>\n

Roode LE, Brighton H, Bo T, Perry JL, Parrott MC, Kersey F, Luft JC, Bear JE, DeSimone JM, Davis IJ.
\n<\/b>Nanomedicine. 2016 May;12(4):1053-62. doi: 10.1016\/j.nano.2015.12.382.
\nPMID: 26772430
\n<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

December was a very productive month for the Department of Genetics faculty, who published 30 manuscripts on a wide variety of topics. An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice. Snouwaert JN, Nguyen M, Repenning PW, Dye R, Livingston EW, Kovarova M, Moy SS, Brigman BE, Bateman TA, Ting JP, Koller BH. Cell … Read more<\/a><\/p>\n","protected":false},"author":22429,"featured_media":2690,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nGenetics Faculty Publications for December 2016 | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/genetics-faculty-publications-for-december-2016\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetics Faculty Publications for December 2016 | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"December was a very productive month for the Department of Genetics faculty, who published 30 manuscripts on a wide variety of topics. 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An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice. Snouwaert JN, Nguyen M, Repenning PW, Dye R, Livingston EW, Kovarova M, Moy SS, Brigman BE, Bateman TA, Ting JP, Koller BH. Cell … Read more","og_url":"https:\/\/www.med.unc.edu\/genetics\/genetics-faculty-publications-for-december-2016\/","og_site_name":"Department of Genetics","article_published_time":"2017-01-04T01:04:11+00:00","article_modified_time":"2018-02-07T16:11:35+00:00","og_image":[{"width":134,"height":173,"url":"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/10\/genetics-faculty-publications-for-december-2016-image.gif","type":"image\/gif"}],"author":"Betsy Clarke","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Betsy Clarke","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/genetics\/genetics-faculty-publications-for-december-2016\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/genetics\/genetics-faculty-publications-for-december-2016\/"},"author":{"name":"Betsy 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