{"id":2747,"date":"2013-03-07T17:45:00","date_gmt":"2013-03-07T22:45:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/mauro-calabrese-a-postdoctoral-fellow-in-terry-magnusons-lab-is-first-author-of-an-article-in-cell-entitled-site-specific-silencing-of-regulatory-elements-as-a-mechanism-of-x-inactivation\/"},"modified":"2021-05-20T13:48:03","modified_gmt":"2021-05-20T17:48:03","slug":"mauro-calabrese-a-postdoctoral-fellow-in-terry-magnusons-lab-is-first-author-of-an-article-in-cell-entitled-site-specific-silencing-of-regulatory-elements-as-a-mechanism-of-x-inactivation","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/mauro-calabrese-a-postdoctoral-fellow-in-terry-magnusons-lab-is-first-author-of-an-article-in-cell-entitled-site-specific-silencing-of-regulatory-elements-as-a-mechanism-of-x-inactivation\/","title":{"rendered":"Mauro Calabrese, a postdoctoral fellow in Terry Magnuson’s lab, is first-author of an article in Cell"},"content":{"rendered":"

<\/p>\n

Paper titled “Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation.”<\/p>\n

<\/div>\n

Mauro Calabrese, a postdoctoral fellow in Terry Magnuson’s lab, is first-author of an article in Cell<\/i> entitled “<\/a>Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation<\/a>.”<\/a> Coauthors with current or previous Department of Genetics affiliations are Wei Sun, Joshua Mugford, Lucy Williams, Della Yee, Joshua Starmer, and Piotr Mieczkowski, with Terry as senior author.<\/p>\n

Summary<\/strong><\/span><\/p>\n

“The inactive X chromosome’s (Xi) physical territory is microscopically devoid of transcriptional hallmarks and enriched in silencing-associated modifications. How these microscopic signatures relate to specific Xi sequences is unknown. Therefore, we profiled Xi gene expression and chromatin states at high resolution via allele-specific sequencing in mouse trophoblast stem cells. Most notably, X-inactivated transcription start sites harbored distinct epigenetic signatures relative to surrounding Xi DNA. These sites displayed H3-lysine27-trimethylation enrichment and DNaseI hypersensitivity, similar to autosomal Polycomb targets, yet excluded Pol II and other transcriptional hallmarks, similar to nontranscribed genes. CTCF bound X-inactivated and escaping genes, irrespective of measured chromatin boundaries. Escape from X inactivation occurred within, and X inactivation was maintained exterior to, the area encompassed by Xist in cells subject to imprinted and random X inactivation. The data support a model whereby inactivation of specific regulatory elements, rather than a simple chromosome-wide separation from transcription machinery, governs gene silencing over the Xi.”<\/p>\n

Highlights<\/h4>\n
\n

“\u25ba RNA-Seq analysis finds 13% of genes escape X inactivation in trophoblast stem cells \u25ba Inactive X regulatory elements lack Pol II binding yet retain DNaseI hypersensitivity \u25ba CTCF binds across the inactive X, mostly to locations shared with the active X \u25ba X-inactivated genes near escapers are often separated from the measured Xist cloud.”<\/p>\n

View the article online in Cell 151(6): 951-963, 2012.<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Paper titled “Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation.” Mauro Calabrese, a postdoctoral fellow in Terry Magnuson’s lab, is first-author of an article in Cell entitled “Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation.” Coauthors with current or previous Department of Genetics affiliations are Wei Sun, Joshua Mugford, … Read more<\/a><\/p>\n","protected":false},"author":22429,"featured_media":2748,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[351,53],"class_list":["post-2747","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-calabrese","tag-magnuson","odd"],"acf":[],"yoast_head":"\nMauro Calabrese, a postdoctoral fellow in Terry Magnuson's lab, is first-author of an article in Cell | Department of 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