{"id":2797,"date":"2014-10-27T16:05:00","date_gmt":"2014-10-27T20:05:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins\/"},"modified":"2018-02-07T12:47:45","modified_gmt":"2018-02-07T17:47:45","slug":"shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins\/","title":{"rendered":"Shawn Ahmed and colleagues publish a paper in PNAS demonstrating a novel function of two C. elegans RNA interference proteins"},"content":{"rendered":"<p><!-- description --><\/p>\n<p class=\"lead\">Shawn and Eric Miska at the University of Cambridge are senior authors on the paper, and Shawn&#8217;s former postdoc, Aisa Sakaguchi, and former graduate student, Matt Simon, as co-first authors with Peter Sarkies from Dr. Miska&#8217;s lab.<\/p>\n<div class=\"newsitem\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/10\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins-image2.jpeg\" alt=\"\" width=\"200\" height=\"250\" \/><\/div>\n<div>This study establishes a role for small RNAs in promoting transgenerational fertility via an endogenous temperature-sensitive silencing process that is promoted by the RNAi spreading defective (RSD)-2 and RSD-6 proteins, which have been implicated in RNA interference in response to exogenous double-stranded RNA triggers. The data suggest that a malleable siRNA-based repeat silencing system in germ cells, which may be subject to stochastic, genetic, or epigenetic effects in human populations, could explain some of the transgenerational variation in the penetrance of aging-related disorders<\/div>\n<div><i><br \/>\n<\/i><\/div>\n<div><a class=\"external-link\" title=\"\" href=\"http:\/\/www.pnas.org\/content\/111\/41\/E4323.full\" target=\"_blank\" rel=\"noopener noreferrer\">Read the article online.<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Shawn and Eric Miska at the University of Cambridge are senior authors on the paper, and Shawn&#8217;s former postdoc, Aisa Sakaguchi, and former graduate student, Matt Simon, as co-first authors with Peter Sarkies from Dr. Miska&#8217;s lab. This study establishes a role for small RNAs in promoting transgenerational fertility via an endogenous temperature-sensitive silencing process &hellip; <a href=\"https:\/\/www.med.unc.edu\/genetics\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins\/\" aria-label=\"Read more about Shawn Ahmed and colleagues publish a paper in PNAS demonstrating a novel function of two C. elegans RNA interference proteins\">Read more<\/a><\/p>\n","protected":false},"author":22429,"featured_media":2798,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Shawn Ahmed and colleagues publish a paper in PNAS demonstrating a novel function of two C. elegans RNA interference proteins | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Shawn Ahmed and colleagues publish a paper in PNAS demonstrating a novel function of two C. elegans RNA interference proteins | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Shawn and Eric Miska at the University of Cambridge are senior authors on the paper, and Shawn&#8217;s former postdoc, Aisa Sakaguchi, and former graduate student, Matt Simon, as co-first authors with Peter Sarkies from Dr. Miska&#8217;s lab. This study establishes a role for small RNAs in promoting transgenerational fertility via an endogenous temperature-sensitive silencing process &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2014-10-27T20:05:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-02-07T17:47:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/10\/shawn-ahmed-and-colleagues-publish-a-paper-in-pnas-demonstrating-a-novel-function-of-two-c-elegans-rna-interference-proteins-image.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" 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