{"id":2806,"date":"2013-11-15T18:15:00","date_gmt":"2013-11-15T23:15:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/terry-furey-and-praveen-sethupathy-coauthor-a-perspective-in-science\/"},"modified":"2021-05-20T13:24:13","modified_gmt":"2021-05-20T17:24:13","slug":"terry-furey-and-praveen-sethupathy-coauthor-a-perspective-in-science","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/terry-furey-and-praveen-sethupathy-coauthor-a-perspective-in-science\/","title":{"rendered":"Terry Furey and Praveen Sethupathy coauthor a Perspective in Science"},"content":{"rendered":"<p><!-- description --><\/p>\n<p class=\"lead\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-10549 alignright\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2013\/11\/Furey-and-Sethupathy.jpg\" alt=\"Furey and Sethupathy\" width=\"288\" height=\"247\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2013\/11\/Furey-and-Sethupathy.jpg 618w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2013\/11\/Furey-and-Sethupathy-300x257.jpg 300w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2013\/11\/Furey-and-Sethupathy-600x515.jpg 600w\" sizes=\"auto, (max-width: 288px) 100vw, 288px\" \/>The Perspective is entitled &#8220;Genetics Driving Epigenetics.&#8221;<\/p>\n<div>The article discusses three reports on DNA variants in the human genome that affect gene regulation epigenetically, <i>via<\/i> sequence-specific binding-affinity of transcription factors. The results of these studies suggest a model in which the differential binding leads to variation in histone tail modification. In some cases, these variations lead to differences in gene expression, which can manifest as phenotypic variation for quantitative traits in the population.<\/div>\n<div><span style=\"line-height: 1.43em\">\u00a0<\/span><\/div>\n<div><span style=\"line-height: 1.43em\">Read the <\/span><a style=\"line-height: 1.43em\" href=\"http:\/\/www.sciencemag.org\/content\/342\/6159\/705.full\">Perspective<\/a>,<span style=\"line-height: 1.43em\"> &#8220;Genetics Driving Epigenetics,&#8221; in <em>Science<\/em>.<\/span><\/div>\n<div><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The article discusses three reports on DNA variants in the human genome that affect gene regulation epigenetically, via sequence-specific binding-affinity of transcription factors.<\/p>\n","protected":false},"author":22429,"featured_media":10549,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[109,196],"class_list":["post-2806","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-furey","tag-sethupathy","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Terry Furey and Praveen Sethupathy coauthor a Perspective in Science | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/terry-furey-and-praveen-sethupathy-coauthor-a-perspective-in-science\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Terry Furey and Praveen Sethupathy coauthor a Perspective in Science | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"The article discusses three reports on DNA variants in the human genome that affect gene regulation epigenetically, via sequence-specific binding-affinity of transcription factors.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/terry-furey-and-praveen-sethupathy-coauthor-a-perspective-in-science\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Genetics\" \/>\n<meta property=\"article:published_time\" content=\"2013-11-15T23:15:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-20T17:24:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2013\/11\/Furey-and-Sethupathy.jpg\" \/>\n\t<meta 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