{"id":6566,"date":"2018-12-17T09:16:18","date_gmt":"2018-12-17T14:16:18","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=6566"},"modified":"2018-12-17T12:01:18","modified_gmt":"2018-12-17T17:01:18","slug":"department-of-genetics-publications-for-dec-2-15-2018","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-dec-2-15-2018\/","title":{"rendered":"Department of Genetics Publications for Dec. 2-15, 2018"},"content":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published fourteen papers during December 2-15, 2018.\u00a0<\/p>\n\n\n\n\n\n\n
<\/td>\nThe Unreasonable Effectiveness of Convolutional Neural Networks in Population Genetic Inference.<\/a><\/td>\n<\/tr>\n
<\/td>\nFlagel L, Brandvain Y, Schrider DR<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nMol Biol Evol. 2018 Dec 4. doi: 10.1093\/molbev\/msy224. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30517664<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nInteractome determination of a Long Noncoding RNA implicated in Embryonic Stem Cell Self-Renewal.<\/a><\/td>\n<\/tr>\n
<\/td>\nSmith KN, Starmer J, Magnuson T.<\/strong><\/td>\n<\/tr>\n
<\/td>\nSci Rep. 2018 Dec 4;8(1):17568. doi: 10.1038\/s41598-018-34864-z.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30514857<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nSWI\/SNF remains localized to chromatin in the presence of SCHLAP1.<\/a><\/td>\n<\/tr>\n
<\/td>\nRaab JR, Smith KN, Spear CC, Manner CJ<\/strong>, Calabrese JM, Magnuson T<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nNat Genet. 2018 Dec 3. doi: 10.1038\/s41588-018-0272-z. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30510238<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nComprehensive functional genomic resource and integrative model for the human brain.<\/a><\/td>\n<\/tr>\n
<\/td>\nWang D, Liu S, Warrell J, Won H<\/strong>, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, G\u00fcm\u00fc\u015f ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB.<\/td>\n<\/tr>\n
<\/td>\nScience. 2018 Dec 14;362(6420). pii: eaat8464. doi: 10.1126\/science.aat8464.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30545857<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nTranscriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.<\/a><\/td>\n<\/tr>\n
<\/td>\nGandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H<\/strong>, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH.<\/td>\n<\/tr>\n
<\/td>\nScience. 2018 Dec 14;362(6420). pii: eaat8127. doi: 10.1126\/science.aat8127.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30545856<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nEZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.<\/a><\/td>\n<\/tr>\n
<\/td>\nMu W, Starmer J, Yee D, Magnuson T<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nEpigenetics Chromatin. 2018 Dec 6;11(1):71. doi: 10.1186\/s13072-018-0242-9.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30522506<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nCommon-variant associations with fragile X syndrome.<\/a><\/td>\n<\/tr>\n
<\/td>\nCrowley JJ, Szatkiewicz J<\/strong>, K\u00e4hler AK, Giusti-Rodriguez P, Ancalade N, Booker JK<\/strong>, Carr JL, Crawford GE, Losh M, Stockmeier CA, Taylor AK, Piven J, Sullivan PF<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nMol Psychiatry. 2018 Dec 7. doi: 10.1038\/s41380-018-0290-3. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30531935<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nClinical validity assessment of genes frequently tested on hereditary breast and ovarian cancer susceptibility sequencing panels.<\/a><\/td>\n<\/tr>\n
<\/td>\nLee K, Seifert BA<\/strong>, Shimelis H, Ghosh R, Crowley SB<\/strong>, Carter NJ, Doonanco K, Foreman AK,<\/strong> Ritter DI, Jimenez S, Trapp M<\/strong>, Offit K, Plon SE, Couch FJ.<\/td>\n<\/tr>\n
<\/td>\nGenet Med. 2018 Dec 3. doi: 10.1038\/s41436-018-0361-5. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30504931<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nCorrection to: Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.<\/a><\/td>\n<\/tr>\n
<\/td>\nShorter JR<\/strong>, Huang W, Beak JY, Hua K<\/strong>, Gatti DM, de Villena FP, Pomp D<\/strong>, Jensen BC.<\/td>\n<\/tr>\n
<\/td>\nMamm Genome. 2018 Dec 4. doi: 10.1007\/s00335-018-9789-9. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30515527<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nDetermining the clinical validity of hereditary colorectal cancer and polyposis susceptibility genes using the Clinical Genome Resource Clinical Validity Framework.<\/a><\/td>\n<\/tr>\n
<\/td>\nSeifert BA, McGlaughon JL<\/strong>, Jackson SA, Ritter DI, Roberts ME, Schmidt RJ, Thompson BA, Jimenez S<\/strong>, Trapp M, Lee K<\/strong>, Plon SE, Offit K, Stadler ZK, Zhang L, Greenblatt MS, Ferber MJ.<\/td>\n<\/tr>\n
<\/td>\nGenet Med. 2018 Dec 7. doi: 10.1038\/s41436-018-0373-1. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30523343<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.<\/a><\/td>\n<\/tr>\n
<\/td>\nFranceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitk\u00e4nen N, Franz\u00e9n O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O’Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, V\u00f6lzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM<\/strong>, Launer LJ, Holdt LM, D\u00f6rr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, H\u00e4gg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtim\u00e4ki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytik\u00e4inen LP, Loeffler M, Evans MK, Debette S, Humphries SE, V\u00f6lker U, Gudnason V, Hingorani AD, Bj\u00f6rkegren JLM, Casas JP, O’Donnell CJ.<\/td>\n<\/tr>\n
<\/td>\nNat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038\/s41467-018-07340-5.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30510157<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nAdaptively weighted large-margin angle-based classifiers.<\/a><\/td>\n<\/tr>\n
<\/td>\nFu S, Zhang S, Liu Y.<\/td>\n<\/tr>\n
<\/td>\nJ Multivar Anal. 2018 Jul;166:282-299. doi: 10.1016\/j.jmva.2018.03.004. Epub 2018 Mar 15.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30546163<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nGenetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.<\/a><\/td>\n<\/tr>\n
<\/td>\nMatson BC, Li M, Trincot CE, Blakeney ES, Pierce SL, Caron KM<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nPeptides. 2018 Dec 8. pii: S0196-9781(18)30237-7. doi: 10.1016\/j.peptides.2018.11.005. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30537525<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nIntrathecal heparan-N-sulfatase in patients with Sanfilippo syndrome type A: A phase IIb randomized trial.<\/a><\/td>\n<\/tr>\n
<\/td>\nWijburg FA, Whitley CB, Muenzer J<\/strong>, Gasperini S, Del Toro M, Muschol N, Cleary M, Sevin C, Shapiro E, Bhargava P, Kerr D, Alexanderian D.<\/td>\n<\/tr>\n
<\/td>\nMol Genet Metab. 2018 Oct 24. pii: S1096-7192(18)30535-3. doi: 10.1016\/j.ymgme.2018.10.006. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30528227<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published fourteen papers during December 2-15, 2018.<\/p>\n","protected":false},"author":28418,"featured_media":6539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[30,28],"class_list":["post-6566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-publications","tag-unc-genetics","odd"],"acf":[],"yoast_head":"\nDepartment of Genetics Publications for Dec. 2-15, 2018 | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-dec-2-15-2018\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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