{"id":6715,"date":"2019-01-25T09:21:49","date_gmt":"2019-01-25T14:21:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=6715"},"modified":"2019-03-05T14:15:26","modified_gmt":"2019-03-05T19:15:26","slug":"jason-whitmire-awarded-r01-from-niaid","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/jason-whitmire-awarded-r01-from-niaid\/","title":{"rendered":"Jason Whitmire Awarded R01 from NIAID"},"content":{"rendered":"<p class=\"lead\">Jason Whitmire, PhD (Associate Professor, Genetics) is the PI on a new award from NIAID.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-6718 alignright\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/01\/jason-whitmore.jpg\" alt=\"\" width=\"188\" height=\"250\" \/><\/p>\n<p>The project, titled \u201cRegulation of CD8+ T cell responses to chronic virus infection\u201d starts in February and represents the second R01 that Jason has secured recently.\u00a0 The project is focused on understanding why CD8+ T cells undergo excessive apoptosis or become functionally inactive and unable to resolve infection during chronic viral infections in mice and humans.\u00a0 Jason\u2019s lab recently identified a critical link between CD8+ T cell expression of UTX, an H3K27 demethylase, and impaired CD8+ T cell responses to chronic lymphocytic choriomeningitis virus (LCMV) infection in mice. Virus-specific CD8+ T cells lacking UTX showed improved accumulation and maintenance over time, reduced expression of the inhibitory receptors, and were resistant to apoptosis. Data suggest that UTX restricts virus-specific CD8+ T cell responses by increasing T cell expression of inhibitory receptors, perhaps converting cells with memory potential into functionally exhausted or senescent cells.<\/p>\n<p><u><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-6716\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/01\/Whitmire-UTX-grant1.jpg\" alt=\"\" width=\"600\" height=\"502\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/01\/Whitmire-UTX-grant1.jpg 711w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/01\/Whitmire-UTX-grant1-300x251.jpg 300w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/01\/Whitmire-UTX-grant1-612x512.jpg 612w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/>The central hypothesis<\/u> is that UTX controls T cell differentiation through a mixture of demethylase-<em>dependent<\/em> and demethylase-<em>independent<\/em> mechanisms that promote gene expression, including at inhibitory receptor loci.\u00a0 Information learned from this project will be useful for comprehending how epigenetic changes due to histone methylation guide CD8+ T cell exhaustion. Long-term, the research may implicate the use of pharmacologic inhibitors of UTX to improve CD8+ T cell-mediated immune defenses.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jason Whitmire, PhD (Associate Professor, Genetics) is the PI on a new award from NIAID.<\/p>\n","protected":false},"author":28418,"featured_media":6718,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-6715","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jason Whitmire Awarded R01 from NIAID | Department of Genetics<\/title>\n<meta name=\"robots\" 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