{"id":6955,"date":"2019-03-08T16:03:55","date_gmt":"2019-03-08T21:03:55","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=6955"},"modified":"2019-03-08T16:07:16","modified_gmt":"2019-03-08T21:07:16","slug":"hector-franco-phd-awarded-dod-breast-cancer-research-program-breakthrough-award","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/hector-franco-phd-awarded-dod-breast-cancer-research-program-breakthrough-award\/","title":{"rendered":"Hector Franco PhD, Awarded DoD Breast Cancer Research Program Breakthrough Award"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6611 alignleft\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-232x300.jpg\" alt=\"Dr. Hector Franco\" width=\"232\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-232x300.jpg 232w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-791x1024.jpg 791w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-768x994.jpg 768w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-1187x1536.jpg 1187w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-1583x2048.jpg 1583w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-600x776.jpg 600w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2017\/02\/Dr.Franco-Headshot-Croped-scaled.jpg 1978w\" sizes=\"auto, (max-width: 232px) 100vw, 232px\" \/><\/p>\n<p class=\"lead\">Dr. Hector Franco, Assistant Professor of Genetics and Member, Lineberger Cancer Center was awarded one of only four breakthrough grants issued this round from the Department of Defense Breast Cancer Research Program.<\/p>\n<p>\u00a0 <img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6956 alignright\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/03\/Hector-Lab-260x300.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/03\/Hector-Lab-260x300.jpg 260w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/03\/Hector-Lab-768x886.jpg 768w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/03\/Hector-Lab-887x1024.jpg 887w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/03\/Hector-Lab-444x512.jpg 444w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2019\/03\/Hector-Lab.jpg 975w\" sizes=\"auto, (max-width: 260px) 100vw, 260px\" \/>The three-year project, titled \u201cMechanisms of Non-coding Enhancer RNA Function in Triple Negative Breast Cancer\u201d is based on preliminary data that demonstrates that improper eRNA function can lead to uncontrolled gene expression allowing cells to escape regulated cell growth, leading to cancer initiation and progression.\u00a0 The objective is to understand the molecular mechanisms by which eRNA-producing enhancers control global patterns of gene expression to regulate biological outcomes in triple-negative breast cancer (TNBC).\u00a0 To test the hypothesis that eRNAs act locally at the enhancer from which they originate, functioning as a scaffold for assembling components of an active enhancer complex, the project focuses on three specific aims:\u00a0 <em>Aim1:<\/em> Examine the functions of transcribed versus non-transcribed enhancers in TNBC. <em>Aim 2:<\/em> Systematically determine the functions and target genes of eRNA producing enhancers using high throughput epigenetic silencing in single cells. <em>Aim 3:<\/em> Determine the molecular mechanisms and biological consequences of eRNA function in TNBC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Hector Franco, Assistant Professor of Genetics and Member, Lineberger Cancer Center was awarded one of only four breakthrough grants issued this round from the Department of Defense Breast Cancer Research Program.\u00a0<\/p>\n","protected":false},"author":28418,"featured_media":6611,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-6955","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hector Franco PhD, Awarded DoD Breast Cancer Research Program Breakthrough Award | Department of 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