{"id":6960,"date":"2019-03-11T09:16:53","date_gmt":"2019-03-11T13:16:53","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=6960"},"modified":"2019-03-11T09:21:32","modified_gmt":"2019-03-11T13:21:32","slug":"department-of-genetics-publications-for-feb-24-march-9-2019","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-feb-24-march-9-2019\/","title":{"rendered":"Department of Genetics Publications for Feb. 24 \u2013 March 9, 2019"},"content":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published seventeen papers during February 24 \u2013 March 9, 2019<\/p>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nGenetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing.<\/a><\/td>\n<\/tr>\n
<\/td>\nKunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamuji\u0107-\u010comi\u0107 H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hern\u00e1ndez I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo \u00c1, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Fr\u00f6lich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, K\u00f6lsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, H\u00fcll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, J\u00f6ckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, N\u00f6then MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O’Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Boss\u00f9 P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC,<\/strong> Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y; Alzheimer Disease Genetics Consortium (ADGC),; European Alzheimer\u2019s Disease Initiative (EADI),; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),; Genetic and Environmental Risk in AD\/Defining Genetic, Polygenic and Environmental Risk for Alzheimer\u2019s Disease Consortium (GERAD\/PERADES),, Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O’Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA.<\/td>\n<\/tr>\n
<\/td>\nNat Genet. 2019 Mar;51(3):414-430. doi: 10.1038\/s41588-019-0358-2. Epub 2019 Feb 28.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30820047<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nThe long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours.<\/a><\/td>\n<\/tr>\n
<\/td>\nLundberg A, Lindstr\u00f6m LS, Li J, Harrell JC, Darai-Ramqvist E, Sifakis EG, Foukakis T, Perou CM<\/strong>, Czene K, Bergh J, Tobin NP.<\/td>\n<\/tr>\n
<\/td>\nBreast Cancer Res. 2019 Feb 28;21(1):34. doi: 10.1186\/s13058-019-1121-4.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30819233<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nGenome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.<\/a><\/td>\n<\/tr>\n
<\/td>\nJansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Mu\u00f1oz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T; 23andMe Research Team, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF<\/strong>, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D.<\/td>\n<\/tr>\n
<\/td>\nNat Genet. 2019 Mar;51(3):394-403. doi: 10.1038\/s41588-018-0333-3. Epub 2019 Feb 25.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30804565<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nIdentification of common genetic risk variants for autism spectrum disorder.<\/a><\/td>\n<\/tr>\n
<\/td>\nGrove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, B\u00e6kvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, N\u00e6rland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnstr\u00f6m K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF<\/strong>, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, B\u00f8rglum AD.<\/td>\n<\/tr>\n
<\/td>\nNat Genet. 2019 Mar;51(3):431-444. doi: 10.1038\/s41588-019-0344-8. Epub 2019 Feb 25.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30804558<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nAnticipated responses of early adopter genetic specialists and nongenetic specialists to unsolicited genomic secondary findings.<\/a><\/td>\n<\/tr>\n
<\/td>\nChristensen KD, Bernhardt BA, Jarvik GP, Hindorff LA, Ou J, Biswas S, Powell BC<\/strong>, Grundmeier RW, Machini K, Karavite DJ, Pennington JW, Krantz ID, Berg JS<\/strong>, Goddard KAB.<\/td>\n<\/tr>\n
<\/td>\nGenet Med. 2018 Oct;20(10):1186-1195. doi: 10.1038\/gim.2017.243. Epub 2018 Feb 1.<\/td>\n<\/tr>\n
<\/td>\nPMID: 29388940<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nSecondary findings: How did we get here, and where are we going?<\/a><\/td>\n<\/tr>\n
<\/td>\nOrmond KE, O’Daniel JM<\/strong>, Kalia SS.<\/td>\n<\/tr>\n
<\/td>\nJ Genet Couns. 2019 Mar 1. doi: 10.1002\/jgc4.1098. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30821867<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nDynamic changes in lung responses after single and repeated exposures to cigarette smoke in mice.<\/a><\/td>\n<\/tr>\n
<\/td>\nEngle ML, Monk JN, Jania CM, Martin JR, Gomez JC, Dang H, Parker JS<\/strong>, Doerschuk CM.<\/td>\n<\/tr>\n
<\/td>\nPLoS One. 2019 Feb 28;14(2):e0212866. doi: 10.1371\/journal.pone.0212866. eCollection 2019.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30818335<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nOrganoid Cultures for Assessing Intestinal Epithelial Differentiation and Function in Response to Type-2 Inflammation.<\/a><\/td>\n<\/tr>\n
<\/td>\nZwarycz B, Gracz AD, Magness ST<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nMethods Mol Biol. 2018;1799:397-417. doi: 10.1007\/978-1-4939-7896-0_29.<\/td>\n<\/tr>\n
<\/td>\nPMID: 29956167<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nDestin: toolkit for single-cell analysis of chromatin accessibility.<\/a><\/td>\n<\/tr>\n
<\/td>\nUrrutia E, Chen L, Zhou H, Jiang Y<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nBioinformatics. 2019 Mar 1. pii: btz141. doi: 10.1093\/bioinformatics\/btz141. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30821321<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nRevisiting diagnostic criteria for myelodysplastic\/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist.<\/a><\/td>\n<\/tr>\n
<\/td>\nLi P, Shahmarvand N, Lynch D, Gotlib JR, Merker JD<\/strong>, Zehnder JL, George TI, Ohgami RS.<\/td>\n<\/tr>\n
<\/td>\nInt J Lab Hematol. 2019 Feb 27. doi: 10.1111\/ijlh.12981. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30811101<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nNucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells.<\/a><\/td>\n<\/tr>\n
<\/td>\nLi W, Liu W, Kakoki A, Wang R, Adebali O, Jiang Y<\/strong>, Sancar A.<\/td>\n<\/tr>\n
<\/td>\nJ Biol Chem. 2019 Feb 26. pii: jbc.RA119.007861. doi: 10.1074\/jbc.RA119.007861. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30808711<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nNatural history and genotype-phenotype correlations in 72 individuals with SATB2-associated syndrome.<\/a><\/td>\n<\/tr>\n
<\/td>\nZarate YA, Smith-Hicks CL, Greene C, Abbott MA, Siu VM, Calhoun ARUL, Pandya A<\/strong>, Li C, Sellars EA, Kaylor J, Bosanko K, Kalsner L, Basinger A, Slavotinek AM, Perry H, Saenz M, Szybowska M, Wilson LC, Kumar A, Brain C, Balasubramanian M, Dubbs H, Ortiz-Gonzalez XR, Zackai E, Stein Q, Powell CM, Schrier Vergano S, Britt A, Sun A, Smith W, Bebin EM, Picker J, Kirby A, Pinz H, Bombei H, Mahida S, Cohen JS, Fatemi A, Vernon HJ, McClellan R, Fleming LR, Knyszek B, Steinraths M, Velasco Gonzalez C, Beck AE, Golden-Grant KL, Egense A, Parikh A, Raimondi C, Angle B, Allen W, Schott S, Algrabli A, Robin NH, Ray JW, Everman DB, Gambello MJ, Chung WK.<\/td>\n<\/tr>\n
<\/td>\nAm J Med Genet A. 2018 Apr;176(4):925-935. doi: 10.1002\/ajmg.a.38630. Epub 2018 Feb 13.<\/td>\n<\/tr>\n
<\/td>\nPMID: 29436146<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nI-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms.<\/a><\/td>\n<\/tr>\n
<\/td>\nWong KY, Fan C, Tanioka M,<\/strong> Parker JS<\/strong>, Nobel AB, Zeng D, Lin DY, Perou CM<\/strong>.<\/td>\n<\/tr>\n
<\/td>\nGenome Biol. 2019 Mar 7;20(1):52. doi: 10.1186\/s13059-019-1640-4.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30845957<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nSeparation of breast cancer and organ microenvironment transcriptomes in metastases.<\/a><\/td>\n<\/tr>\n
<\/td>\nAlzubi MA, Turner TH, Olex AL, Sohal SS, Tobin NP, Recio SG<\/strong>, Bergh J, Hatschek T, Parker JS<\/strong>, Sartorius CA, Perou CM<\/strong>, Dozmorov MG, Harrell JC.<\/td>\n<\/tr>\n
<\/td>\nBreast Cancer Res. 2019 Mar 6;21(1):36. doi: 10.1186\/s13058-019-1123-2.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30841919<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nThe Evolution of SlyA\/RovA Transcription Factors from Repressors to Countersilencers in <i>Enterobacteriaceae<\/i>.<\/a><\/td>\n<\/tr>\n
<\/td>\nWill WR, Brzovic P, Le Trong I, Stenkamp RE, Lawrenz MB, Karlinsey JE, Navarre WW, Main-Hester K, Miller VL<\/strong>, Libby SJ, Fang FC.<\/td>\n<\/tr>\n
<\/td>\nMBio. 2019 Mar 5;10(2). pii: e00009-19. doi: 10.1128\/mBio.00009-19.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30837332<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nExome sequencing reveals novel variants and unique allelic spectrum for hearing impairment in Filipino cochlear implantees.<\/a><\/td>\n<\/tr>\n
<\/td>\nTruong BT, Yarza TKL, Bootpetch Roberts T, Roberts S, Xu J, Steritz MJ, Tobias-Grasso CAM, Azamian M, Lalani SR, Mohlke KL<\/strong>, Lee NR, Cutiongco-de la Paz EM, Reyes-Quintos MRT, Santos-Cortez RLP, Chiong CM.<\/td>\n<\/tr>\n
<\/td>\nClin Genet. 2019 Mar 4. doi: 10.1111\/cge.13515. [Epub ahead of print] No abstract available.<\/td>\n<\/tr>\n
<\/td>\nPMID: 30828794<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
<\/td>\nAndrogen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts.<\/a><\/td>\n<\/tr>\n
<\/td>\nSikic D, Wirtz RM, Wach S, Dyrskj\u00f8t L, Erben P, Bolenz C, Breyer J, Otto W, Hoadley KA<\/strong>, Lerner SP, Eckstein M, Hartmann A, Keck B.<\/td>\n<\/tr>\n
<\/td>\nTransl Oncol. 2019 Mar 1;12(4):661-668. doi: 10.1016\/j.tranon.2019.01.005. [Epub ahead of print]<\/td>\n<\/tr>\n
<\/td>\nPMID: 30831560<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Department of Genetics faculty, postdocs, students and collaborators published seventeen papers during February 24 \u2013 March 9, 2019.<\/p>\n","protected":false},"author":28418,"featured_media":6539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-6960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nDepartment of Genetics Publications for Feb. 24 \u2013 March 9, 2019 | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/department-of-genetics-publications-for-feb-24-march-9-2019\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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