{"id":4832,"date":"2023-08-10T10:44:41","date_gmt":"2023-08-10T14:44:41","guid":{"rendered":"https:\/\/www.med.unc.edu\/htcenter\/?page_id=4832"},"modified":"2025-07-29T12:05:20","modified_gmt":"2025-07-29T16:05:20","slug":"desmopressin-ddavp-education","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/htcenter\/resources\/medication-resources\/desmopressin-ddavp-education\/","title":{"rendered":"Desmopressin (DDAVP) Education"},"content":{"rendered":"<h2>Use<\/h2>\n<p>DDAVP (desmopressin acetate) is a synthetic hormone used to increase the clotting factors in people with certain bleeding disorder including mild hemophilia A, type 1 von Willebrand disease, and some platelet dysfunction disorders.<\/p>\n<h2>Action<\/h2>\n<p>Temporarily improves factor 8 levels, von Willebrand factor levels and platelet function.<\/p>\n<ul>\n<li>Effect begins in 30 minutes, peaks in 90 minutes, and lasts approximately 12<\/li>\n<\/ul>\n<h2>Dosing<\/h2>\n<p>DDAVP Subcutaneous Injection (desmopressin acetate vial concentration 4mcg\/ml)<\/p>\n<ul>\n<li>Dosage is determined by your weight in kilograms \u2013 3 micrograms per<\/li>\n<li>DDAVP can be used for minor procedures or<\/li>\n<li>DDAVP is <strong>not <\/strong>intended for use with a major or life-threatening bleeding episode (ex: major surgery, bleed in spine, neck, or head, etc.)<\/li>\n<\/ul>\n<h2>Storage<\/h2>\n<p>Keep refrigerated and check the expiration date.<\/p>\n<h2>Side Effects<\/h2>\n<p>Side effects are temporary and occur more frequently when DDAVP is given intravenously.<\/p>\n<p>Common side effects may include:<\/p>\n<ul>\n<li>Slight elevation in blood pressure or pulse<\/li>\n<li>Headache<\/li>\n<li>Nausea<\/li>\n<li>Facial flushing<\/li>\n<li>Dizziness<\/li>\n<li>Urinary retention<\/li>\n<li>Low sodium levels (stomach cramps, muscle weakness, headache, nausea, or vomiting)<\/li>\n<\/ul>\n<h2>Precautions<\/h2>\n<p>To avoid low sodium levels, we recommend the following for 24 hours after DDAVP:<\/p>\n<ul>\n<li><strong>NO more than 5 liters oral and IV fluid combined<\/strong><\/li>\n<li>Avoid plain water and drink only enough to satisfy your thirst\n<ul>\n<li>Gatorade, Vitamin Water, are good alternatives<\/li>\n<\/ul>\n<\/li>\n<li>Eat salty foods and snacks<\/li>\n<li>Avoid drinking caffeine or alcohol<\/li>\n<li>Avoid strenuous workouts or activities that will cause significant sweating<\/li>\n<li>Do not take antidiuretics or \u201cfluid pills\u201d \u2013 talk to your doctor or nurse<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Use DDAVP (desmopressin acetate) is a synthetic hormone used to increase the clotting factors in people with certain bleeding disorder including mild hemophilia A, type 1 von Willebrand disease, and some platelet dysfunction disorders. Action Temporarily improves factor 8 levels, von Willebrand factor levels and platelet function. Effect begins in 30 minutes, peaks in 90 &hellip; <a href=\"https:\/\/www.med.unc.edu\/htcenter\/resources\/medication-resources\/desmopressin-ddavp-education\/\" aria-label=\"Read more about Desmopressin (DDAVP) Education\">Read more<\/a><\/p>\n","protected":false},"author":55097,"featured_media":0,"parent":4830,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4832","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/pages\/4832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/users\/55097"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/comments?post=4832"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/pages\/4832\/revisions"}],"predecessor-version":[{"id":5073,"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/pages\/4832\/revisions\/5073"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/pages\/4830"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/htcenter\/wp-json\/wp\/v2\/media?parent=4832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}