Men and Women Needed for Anal Fissure Research Study

Need Men and Women over the age of 18 suffering from anal or rectal pain

Principal Investigator: Spencer Dorn, MD
UNC Center for Functional GI & Motility Disorders
Bioinformatics Building, CB# 7080
Chapel Hill, NC 27599-7080

Anal Fissures cause rectal pain and bleeding. Often due to constipation, anal fissures are tears in the lining of the anal canal. Affecting nearly up to 10% of the population, it is an extremely painful and debilitating condition.

If you are suffering with anal or rectal pain particularly during or after a bowel movement, you may have an anal fissure and qualify for a research study of an investigational cream (diltiazem).

If you are interested, please contact Renuka Kelapure by phone (919.843-7892) or email (

Participation includes:
• Documenting anal fissure pain daily

• Documenting bowel movements and symptoms

• Giving blood samples

• Completing a no-cost physical exam

• Completing 5 visits during the 5-week study

• Self-administering study medication three times a day

Qualified participants will receive up to $425 compensation for participation.