{"id":6063,"date":"2017-09-14T14:33:57","date_gmt":"2017-09-14T14:33:57","guid":{"rendered":"https:\/\/wordpress-dev.med.unc.edu\/itr\/?page_id=6063"},"modified":"2025-10-27T08:12:37","modified_gmt":"2025-10-27T12:12:37","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/itr\/better-tomorrow-network\/our-research\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Publication from the RISE Pilot (2020 to 2023)<\/h2>\n
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\"Journal<\/a><\/p>\n

Acceptability of a smartphone-based intervention targeting anxiety sensitivity among women receiving emergency care after sexual assault: A pilot uncontrolled trial<\/a><\/h3>\n

October 5, 2023 \u25cf Survivors of recent sexual assault reported that RISE Guide, a CBT-based web application, is acceptable and helpful.<\/p>\n<\/div>\n

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Publications from the Women’s Health Study (2014 to 2020)<\/h2>\n

We completed data collection for the Women’s Health Study in 2020, and continue to publish impactful research from the results of this 5-year, 706-participant study on experiences and health outcomes of sexual assault survivors.<\/p>\n

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Experiences of Women Sexual Assault Survivors With Police in the Early Aftermath of Assault: Results From a Large-scale Prospective Study<\/span><\/a><\/h3>\n
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September 2025 \u25cf This longitudinal research studied women seen by sexual assault nurse examiners (SANEs) in emergency departments soon after sexual assault, focusing on the survivors\u2019 post-assault interactions with police. Findings showed that experiences speaking with police varied by demographic group as well as the existence of previous trauma.<\/div>\n
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\"Journal<\/a><\/p>\n

Research with women sexual assault survivors presenting for emergency care is safe: Results from a multi-site, prospective observational cohort study<\/span><\/a><\/h3>\n
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July 2024 \u25cf This large-scale investigation into the safety of research participation for sexual assault survivors reports that research participation is overwhelmingly perceived as a positive experience and worth the participant’s time. This finding was stable across the year of research and consistent across demographic and clinical groups.<\/div>\n
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\"Journal<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Development of a brief bedside tool to screen women sexual assault survivors for risk of persistent posttraumatic stress six months after sexual assault<\/a><\/h3>\n

June 2024 \u25cf This brief, eight-item risk stratification tool consists of easy-to-collect information and, if validated, may be useful for clinical trial enrichment and\/or patient screening.<\/p>\n

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\"JACEP<\/a><\/p>\n

\u201cI still feel so lost\u201d: Experiences of women receiving SANE care during the year after sexual assault<\/a><\/h3>\n

July 3, 2021 \u25cf Female patients who had been sexually assaulted and who were evaluated at 13 widely geographically distributed sexual assault nurse examiners\u2019 programs consistently reported that the sexual assault nurse examiners provided high-quality, compassionate care.<\/p>\n

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\"Journal<\/a><\/p>\n

Perceived care quality among women receiving sexual assault nurse examiner care: Results from a 1-week postexamination survey in a large multisite prospective Study<\/a><\/h3>\n

May 2021 \u25cf Qualitative analyses of open\u2010ended responses from a large cohort of women sexual assault survivors receiving SANE care highlight the challenges for survivors and can increase understanding among the emergency care practitioners who care for them.<\/p>\n

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\"Depression<\/a><\/p>\n

Health care utilization by women sexual assault survivors after emergency care: Results of a multisite prospective study<\/a><\/h3>\n

January 2021 \u25cf Most women receiving emergency care after sexual assault experience substantial posttraumatic sequelae, but health care in the 6 weeks after assault is uncommon, unrelated to substantive differences in need, and limited in socially disadvantaged groups. Lack of disclosure to primary care providers was common among women who did receive care.<\/p>\n

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\"Journal<\/a><\/p>\n

Anxiety sensitivity prospectively predicts increased acute posttraumatic stress and related symptoms after sexual assault<\/a><\/h3>\n

November 11, 2020 \u25cf In a subsample of 48 women sexual assault survivors enrolled as part of a larger prospective observational study, elevated anxiety sensitivity measured via a brief assessment 1 week after experiencing a sexual assault was concurrently associated with PTSS at 1 week and prospectively predicted PTSS 6 weeks after the event, with small-to-medium effect sizes.<\/p>\n

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\"Biological<\/a><\/p>\n

Psychological and physical morbidity of sexual assault among adult women students [Abstract]<\/a><\/h3>\n

May 1, 2020 \u25cf Adverse physical and mental health outcomes are common among women students who are sexually assaulted. Further studies are needed which evaluate longitudinal health, academic, and career outcomes of women students experiencing sexual assault.<\/p>\n

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\"Biological<\/a><\/p>\n

Peritraumatic circulating 17\u03b2-estradiol as a resiliency factor for chronic pain outcomes in women following trauma [Abstract]<\/a><\/h3>\n

May 1, 2020 \u25cf Increased peritraumatic E2 levels predict improved CPMP outcomes in women.<\/p>\n

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\"Biological<\/a><\/p>\n

Peritraumatic anxiety sensitivity predicts posttraumatic stress symptoms after sexual assault [Abstract]<\/a><\/h3>\n

May 1, 2020 \u25cf Anxiety sensitivity, or fear of anxious arousal, has been shown to predict posttraumatic stress symptoms (PTSS) after campus shootings and analogue traumas. Sexual assault disproportionately impacts women and often results in prolonged PTSS.<\/p>\n

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\"Biological<\/a><\/p>\n

Pain in the immediate aftermath of sexual assault and its relationship to physical trauma during assault [Abstract]<\/a><\/h3>\n

May 1, 2020 \u25cf Pain after SA is a posttraumatic stress disorder.<\/p>\n

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\"Biological<\/a><\/p>\n

Peritraumatic stress symptoms partially mediate pain persistence after sexual assault [Abstract]<\/a><\/h3>\n

May 1, 2020 \u25cf Peritraumatic stress symptoms in the early aftermath of sexual assault influence the transition from acute to persistent pain, particularly dysphoric arousal.<\/p>\n

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\"Biological<\/a><\/p>\n

Predictors of posttraumatic stress six months after sexual assault: Results of a large-scale, multi-site, prospective study [Abstract]<\/a><\/h3>\n

May 1, 2020 \u25cf Identifying predictors of posttraumatic stress may help inform the development of preventive interventions for women who present for emergency care in the immediate aftermath of sexual assault. However, to date no large-scale, multi-site, prospective studies of SA survivors presenting for emergency care have been performed.<\/p>\n

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\"BMJ<\/a><\/p>\n

Protocol for the first large-scale emergency care-based longitudinal cohort study of recovery after sexual assault: the Women\u2019s Health Study<\/a><\/h3>\n

November 21, 2019 \u25cf Women \u226518 years of age who present for emergency care within 72\u2009hours of sexual assault to a network of treatment centres across the USA are approached for study participation. Blood DNA and RNA samples and brief questionnaire and medical record data are obtained from women providing initial consent. Full consent is obtained at initial 1\u2009week follow-up to analyse blood sample data and to perform assessments at 1\u2009week, 6\u2009weeks, 6\u2009months and 1\u2009year.<\/p>\n

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\"Biological<\/a><\/p>\n

Increased adverse childhood experiences predict worse acute pain and psychological symptoms after sexual assault [Abstract]<\/a><\/h3>\n

May 15, 2019 \u25cf Increasing evidence suggests that adverse childhood experiences (ACEs) can result in enduring neurobiological changes that increase pain and psychological vulnerability. To date, the influence of ACEs on acute pain and psychological responses following sexual assault is unknown.<\/p>\n

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\"Biological<\/a><\/p>\n

Sexual assault characteristics predict peritraumatic pain and posttraumatic stress responses [Abstract]<\/a><\/h3>\n

May 15, 2019 \u25cf The association between sexual assault (SA) characteristics on acute pain and psychological responses following SA is unknown.<\/p>\n

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\"Journal<\/a><\/p>\n

A functional riboSNitch in the 3\u2032 untranslated region of FKBP5 alters microRNA-320a binding efficiency and mediates vulnerability to chronic post-traumatic pain<\/a><\/h3>\n

September 26, 2018 \u25cf Bioinformatic, in vitro, and mutational analyses indicate that the rs3800373 minor allele reduces the binding of a stress- and pain-associated microRNA, miR-320a, to FKBP5 via altering the FKBP5 mRNA 3\u2032UTR secondary structure (i.e., is a riboSNitch).<\/p>\n

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\"Biological<\/a><\/p>\n

Most sexual assault survivors with significant posttraumatic stress do not receive mental health care in the initial weeks after assault [Abstract]<\/a><\/h3>\n

May 1, 2018 \u25cf Little data exists regarding receipt of mental health care services by sexual assault survivors in the early aftermath of sexual assault.<\/p>\n

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\"Biological<\/a><\/p>\n

Psychological resilience following sexual assault predicts improved mental health outcomes [Abstract]<\/a><\/h3>\n

May 1, 2018 \u25cf Sexual assault occurs to one in five US women and is associated with a range of adverse neuropsychiatric outcomes, including posttraumatic stress and depressive symptoms. Characteristics associated with increased psychological resilience in the early aftermath of sexual assault remain poorly understood.<\/p>\n

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\"Biological<\/a><\/p>\n

Use of HIV post-exposure prophylaxis among women sexual assault survivors is not sssociated with increased posttraumatic stress symptoms [Abstract]<\/a><\/h3>\n

May 1, 2018 \u25cf To reduce HIV risk, post-exposure prophylaxis (PEP) is prescribed to some women sexual assault (SA) survivors who present for emergency care after SA. However, the use of HIV PEP, and\/or accompanying medication side effects, may serve as reminders of the SA, augmenting posttraumatic stress symptoms (PTSS).<\/p>\n

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\"Western<\/a><\/p>\n

Persistent adverse mental and physical health outcomes are common among women after sexual assault [Abstract]<\/a><\/h3>\n

September 2017 \u25cf Adverse mental and physical health outcomes are common and morbid among sexual assault survivors. Future analyses will include the full participant sample and later follow-up time points.<\/p>\n

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\"Biological<\/a><\/p>\n

Strangulation during sexual assault predicts increased PTSD symptoms six weeks after assault [Abstract]<\/a><\/h3>\n

May 15, 2017 \u25cf Strangulation-associated sexual assault, but not other sexual assault-related characteristics, predict increased posttraumatic stress disorder symptoms six weeks after assault.<\/p>\n

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Publications from the Women’s Health Pilot Study (2008 to 2011)<\/h2>\n

In order to assess the feasibility and challenges of building a multi-site network dedicated to improving the care provided to sexual assault survivors, a pilot study for the Women\u2019s Health Study was undertaken from 2008 to 2011. Results from the pilot informed and supported the development of the Women\u2019s Health Study in 2014.<\/p>\n

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\"Pain,<\/a><\/p>\n

Genetic variant rs3750625 in the 3’UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site<\/a><\/h3>\n

February 2017 \u25cf ADRA2A rs3750625 contributes to poststress musculoskeletal pain severity by modulating miR-34a regulation.<\/p>\n

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\"Pain,<\/a><\/p>\n

Genetic variant rs3750625 in the 3’UTR of Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure<\/a><\/h3>\n

August 2013 \u25cf Glucocorticoid pathways influence the development of persistent posttraumatic pain, and that such pathways may be a target of pharmacologic interventions aimed at improving recovery after trauma.<\/p>\n

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\"Pain,<\/a><\/p>\n

\u03bc-Opioid receptor gene A118G polymorphism predicts pain recovery after sexual assault<\/a><\/h3>\n

February 2013 \u25cf Among 52 white American women SA survivors presenting for care within 48 hours of sexual assault, those with a G allele experienced less severe pain and a reduced extent of pain during the 6 weeks after sexual assault.<\/p>\n

\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Publication from the RISE Pilot (2020 to 2023) Acceptability of a smartphone-based intervention targeting anxiety sensitivity among women receiving emergency care after sexual assault: A pilot uncontrolled trial October 5, 2023 \u25cf Survivors of recent sexual assault reported that RISE Guide, a CBT-based web application, is acceptable and helpful.   Publications from the Women’s Health … Read more<\/a><\/p>\n","protected":false},"author":1369,"featured_media":0,"parent":8409,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-6063","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nPublications - Better Tomorrow Network<\/title>\n<meta name=\"description\" content=\"The Better Tomorrow Network publishes high-quality research serving survivors of sexual assault.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/itr\/better-tomorrow-network\/our-research\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - 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