{"id":2220,"date":"2010-04-24T16:38:30","date_gmt":"2010-04-24T20:38:30","guid":{"rendered":"https:\/\/med.sites.unc.edu\/mackmanlab\/mackmanlab\/nigel-mackman-laboratory\/overview\/"},"modified":"2022-03-17T16:13:05","modified_gmt":"2022-03-17T20:13:05","slug":"overview","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/mackmanlab\/nigel-mackman-laboratory\/overview\/","title":{"rendered":"Overview"},"content":{"rendered":"<p><strong>Overview<\/strong><\/p>\n<p>The Mackman lab studies the roles of tissue factor (TF), coagulation proteases and protease-activated receptors (PARs) in health and disease (Figure 1). We have established a variety of different disease models and have a large number of transgenic mice deficient in different coagulation factors and PARs, as well as mice with low levels of TF and mice with cell type-specific knockout of TF, PAR1 and PAR2. We also use antibodies and pharmacological inhibitors of FXa and thrombin.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2766 size-full\" src=\"https:\/\/www.med.unc.edu\/mackmanlab\/wp-content\/uploads\/sites\/514\/2022\/03\/Figure-1.png\" alt=\"Cancer and viral infections affect tissue factor, coagulation proteases, and PARS function and levels, which in turn affect thrombosis and immune response.\" width=\"925\" height=\"316\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u00a0<\/strong><\/p>\n<p>The TF:FVIIa complex is the physiological initiator of the blood coagulation cascade (Figure 2). Several anticoagulant pathways, such as tissue factor pathway inhibitor (TFPI), regulate the coagulation cascade. A balance between TF and TFPI is require for normal hemostasis.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2579 size-large\" src=\"https:\/\/www.med.unc.edu\/mackmanlab\/wp-content\/uploads\/sites\/514\/2010\/04\/Figure-2-1-1024x576.jpg\" alt=\"Schematic of the coagulation cascade, with inhibitors. Description of important features in previous text.\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.med.unc.edu\/mackmanlab\/wp-content\/uploads\/sites\/514\/2010\/04\/Figure-2-1-1024x576.jpg 1024w, https:\/\/www.med.unc.edu\/mackmanlab\/wp-content\/uploads\/sites\/514\/2010\/04\/Figure-2-1-300x169.jpg 300w, https:\/\/www.med.unc.edu\/mackmanlab\/wp-content\/uploads\/sites\/514\/2010\/04\/Figure-2-1-768x432.jpg 768w, https:\/\/www.med.unc.edu\/mackmanlab\/wp-content\/uploads\/sites\/514\/2010\/04\/Figure-2-1.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Overview The Mackman lab studies the roles of tissue factor (TF), coagulation proteases and protease-activated receptors (PARs) in health and disease (Figure 1). We have established a variety of different disease models and have a large number of transgenic mice deficient in different coagulation factors and PARs, as well as mice with low levels of &hellip; <a href=\"https:\/\/www.med.unc.edu\/mackmanlab\/nigel-mackman-laboratory\/overview\/\" aria-label=\"Read more about Overview\">Read more<\/a><\/p>\n","protected":false},"author":76119,"featured_media":0,"parent":2199,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2220","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Overview - Mackman Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/mackmanlab\/nigel-mackman-laboratory\/overview\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Overview - Mackman Lab\" \/>\n<meta property=\"og:description\" content=\"Overview The Mackman lab studies the roles of tissue factor (TF), coagulation proteases and protease-activated receptors (PARs) in health and disease (Figure 1). 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